高石繁生 (SHIGEO TAKAISHI) - マイポータル

基本情報

ORCID ID: https://orcid.org/0000-0003-2236-6081
J-GLOBAL ID: 201001036697617829
researchmap会員ID: 6000025532

研究キーワード

研究分野

ライフサイエンス / 消化器内科学 /

論文

Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling.

Akitada Yogo, Toshihiko Masui, Shigeo Takaishi, Kenji Masuo, Ru Chen, Yosuke Kasai, Kazuyuki Nagai, Takayuki Anazawa, Sadanori Watanabe, Satoko Sakamoto …

Cancer science 114(4) 1324-1336 2023年4月査読有り責任著者
Prospective study of adoptive activated αβT lymphocyte immunotherapy for refractory cancers: development and validation of a response scoring system.

Atsushi Nonami, Ryu Matsuo, Kouta Funakoshi, Tomohiro Nakayama, Shigenori Goto, Tadafumi Iino, Shigeo Takaishi, Shinichi Mizuno, Koichi Akashi, Masatoshi Eto

Cytotherapy 25(1) 76-81 2023年1月査読有り
JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression

Takaaki Yoshikawa, Akihisa Fukuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Satoshi Ogawa …

Cancer Science 113(10) 3417-3427 2022年8月4日査読有り
Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer.

Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto …

BMC cancer 22(1) 489-489 2022年5月3日査読有り
SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2

Kenji Masuo, Ru Chen, Akitada Yogo, Aiko Sugiyama, Akihisa Fukuda, Toshihiko Masui, Shinji Uemoto, Hiroshi Seno, Shigeo Takaishi

Cancer Science 112(12) 4987-4999 2021年12月査読有り最終著者責任著者
Brg1 is required to maintain colorectal cancer stem cells.

Takaaki Yoshikawa, Akihisa Fukuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Satoshi Ogawa …

The Journal of pathology 255(3) 257-269 2021年7月19日
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL

Ru Chen, Kenji Masuo, Akitada Yogo, Shoko Yokoyama, Aiko Sugiyama, Hiroshi Seno, Akihiko Yoshizawa, Shigeo Takaishi

Carcinogenesis 42(2) 190-201 2021年2月25日査読有り最終著者責任著者
Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells.

Ru Chen, Aiko Sugiyama, Naoyuki Kataoka, Masahiro Sugimoto, Shoko Yokoyama, Akihisa Fukuda, Shigeo Takaishi, Hiroshi Seno

Frontiers in oncology 10 316-316 2020年査読有り責任著者
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.

Kozo Ikuta, Akihisa Fukuda, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Motoyuki Tsuda, Yoshito Kimura, Yoshihide Matsumoto, Yuto Kimura …

Gut 68(5) 882-892 2019年5月査読有り
Arid1a is essential for intestinal stem cells through Sox9 regulation.

Yukiko Hiramatsu, Akihisa Fukuda, Satoshi Ogawa, Norihiro Goto, Kozo Ikuta, Motoyuki Tsuda, Yoshihide Matsumoto, Yoshito Kimura, Takuto Yoshioka, Yutaka Takada …

Proceedings of the National Academy of Sciences of the United States of America 116(5) 1704-1713 2019年1月29日査読有り
E‑cadherin regulates proliferation of colorectal cancer stem cells through NANOG.

Shingo Tamura, Taichi Isobe, Hiroshi Ariyama, Michitaka Nakano, Yoshikane Kikushige, Shigeo Takaishi, Hitoshi Kusaba, Katsuto Takenaka, Takashi Ueki, Masafumi Nakamura …

Oncology reports 40(2) 693-703 2018年8月査読有り
A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells

Koichi Sasaki, Yoshiki Miyashita, Daisuke Asai, Daiki Funamoto, Kazuki Sato, Yoko Yamaguchi, Yuji Mishima, Tadafumi Iino, Shigeo Takaishi, Jun Nagano …

MedChemComm 9(5) 783-788 2018年査読有り
大腸がん幹細胞分画におけるE-カドヘリン陽性細胞とE-カドヘリン陰性細胞の病理学的差異についての検討

田村真吾, 磯部大地, 有山寛, 中野倫孝, 植木隆, 高石繁生, 草場仁志, 馬場英司, 赤司浩一

日本癌学会総会記事 74回 J-1124 2015年10月
Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study.

Youko Suehiro, Atsuhiko Hasegawa, Tadafumi Iino, Amane Sasada, Nobukazu Watanabe, Masao Matsuoka, Ayako Takamori, Ryuji Tanosaki, Atae Utsunomiya, Ilseung Choi …

British journal of haematology 169(3) 356-67 2015年5月査読有り
CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.

Yoku Hayakawa, Guangchun Jin, Hongshan Wang, Xiaowei Chen, Christoph B Westphalen, Samuel Asfaha, Bernhard W Renz, Hiroshi Ariyama, Zinaida A Dubeykovskaya, Yoshihiro Takemoto …

Gut 64(4) 544-53 2015年4月査読有り
Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan.

Taichi Isobe, Keita Uchino, Chinatsu Makiyama, Hiroshi Ariyama, Shuji Arita, Shingo Tamura, Masato Komoda, Hitoshi Kusaba, Tsuyoshi Shirakawa, Taito Esaki …

Anticancer research 34(4) 2035-40 2014年4月査読有り
Pemetrexed combined with platinum-based chemotherapy for advanced malignant peritoneal mesothelioma: retrospective analysis of six cases.

Michitaka Nakano, Hitoshi Kusaba, Akitaka Makiyama, Hiroshi Ariyama, Shuji Arita, Hisanobu Oda, Taito Esaki, Kotoe Takayoshi, Keita Uchino, Shingo Tamura …

Anticancer research 34(1) 215-20 2014年1月査読有り
Efficacy and safety of an increased-dose of dexamethasone in patients receiving fosaprepitant chemotherapy in Japan.

Hozumi Kumagai, Hitoshi Kusaba, Yuta Okumura, Masato Komoda, Michitaka Nakano, Shingo Tamura, Mayako Uchida, Kenichiro Nagata, Shuji Arita, Hiroshi Ariyama …

Asian Pacific journal of cancer prevention : APJCP 15(1) 461-5 2014年査読有り
Systemic chemotherapy for metastatic non-mucinous appendiceal adenocarcinoma: a case report and literature review

Kenji Tsuchihashi, Kotoe Takayoshi, Keita Uchino, Tsuyoshi Shirakawa, Hozumi Kumagai, Shingo Tamura, Masato Komoda, Taichi Isobe, Shigeo Takaishi, Hitoshi Kusaba …

International Cancer Conference Journal 2(1) 36-40 2013年1月
大腸癌においてはE-Cadherin陽性細胞、陰性細胞ともにがん幹細胞性をもつ(Both E-Cadherin-positive and negative cells of colorectal cancer stem cell population possess tumor initiating potential)

田村真吾, 磯部大地, 馬場英司, 中野倫孝, 薦田正人, 高石繁生, 草場仁志, 植木隆, 赤司浩一

日本癌学会総会記事 71回 244-244 2012年8月

もっとみる

MISC

EMT関連因子SNAILは、2つの遺伝子CCN3 およびNEFLを通じて胃発癌を制御する

陳如, 高石繁生, 増尾謙志, 余語覚匡, 杉山愛子, 妹尾浩

日本癌学会総会記事 79回-OE14-1-4 2020年10月責任著者
胆道癌におけるドーパミンの自己分泌作用は癌幹細胞の微小環境に寄与する日本癌学会総会記事

余語覚匡, 高石繁生, 増尾謙志, 陳如, 増井俊彦, 妹尾浩

日本癌学会総会記事 78回-P-3303 2019年9月責任著者
SNAIL2は膵癌の幹細胞性維持において重要である

増尾謙志, 高石繁生, 余語覚匡, 陳如, 福田晃久, 増井俊彦, 妹尾浩

日本癌学会総会記事 78回 P-P-1052 2019年9月責任著者
手術検体を基にした膵・胆道腫瘍患者由来3次元スフェロイド樹立の試み

余語覚匡, 増井俊彦, 内田雄一郎, 仲野健三, 穴澤貴行, 高折恭一, 高石繁生, 妹尾浩, 上本伸二

日本消化器外科学会総会 74回 P285-2 2019年7月
Macrophage-to-fibroblast transition promotes cancer progression in peritoneal carcinomatosis of gastrointestinal cancer patient

Mamoru Tanaka, Michitaka Nakano, Hiroshi Ariyama, Kyoko Inadomi, Risa Tanaka, Shigeo Takaishi, Hitoshi Kusaba, Eishi Baba, Koichi Akashi

CANCER RESEARCH 76 2016年7月
Epithelial mesenchymal transition generates cancer stem cells in CD44-colorectal cancer cells

Michitaka Nakano, Mamoru Tanaka, Taichi Isobe, Kohta Miyawaki, Yoshikane Kikushige, Hitoshi Kusaba, Shigeo Takaishi, Takashi Ueki, Eishi Baba, Koichi Akashi

CANCER RESEARCH 76 2016年7月
CCK2R marks gastric antral stem cell and mediates antral carcinogenesis

Hayakawa Yoku, Guanchun Jin, Hongshan Wang, Xiaowei Chen, Christoph B. Westphalen, Samuel Asfaha, Daniel L. Worthley, Bernhard Renz, Hiroshi Ariyama, Zinaida A. Dubeykovskaya …

CANCER RESEARCH 74(19) 2014年10月
Progastrin Promotes Antral Carcinogenesis and Gastric Stem Cell Function

Yoku Hayakawa, Shigeo Takaishi, Guangchun Jin, Hiroshi Ariyama, Christoph B. Westphalen, Samuel Asfaha, Yagnesh H. Tailor, Wataru Shibata, Xiangdong Yang, Duan Chen …

GASTROENTEROLOGY 144(5) S152-S153 2013年5月
The Effect of Folate Supplementation on Global Methylation and Progression of Gastric Cancer in the Transgenic Hypergastrinemic Murine Model

Lamas A. Gonda, Shigeo Takaishi, Wataru Shibata, Julian A. Abrams, Mary V. Gamble, Timothy C. Wang, Benjamin Tycko

GASTROENTEROLOGY 140(5) S158-S158 2011年5月
Mesenchyrnal Stem Cells Derived Myofibroblasts Function as Niche Cells in the Normal Bone Marrow and Expand During Carcinogenesis to Promote Tumor Growth

Michael Quante, Shuiping Tu, Hiroyuki Tomita, Tamas A. Gonda, Wataru Shibata, Shigeo Takaishi, Andrea Varro, Benjamin Tycko, Timothy C. Wang

GASTROENTEROLOGY 140(5) S825-S826 2011年5月
Epithelial-mesenchymal transition(EMT)--上皮間葉転換

草場仁志, 高石繁生, 馬場英司

腫瘍内科 7(3) 292-297 2011年3月
Overexpression of Interleukin-1 beta Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice (vol 14, pg 408, 2008)

Shuiping Tu, Govind Bhagat, Guanglin Cui, Shigeo Takaishi, Evelyn A. Kurt-Jones, Barry Rickman, Kelly S. Betz, Melitta Penz, Olle Bjorkdhl, James G. Fox …

CANCER CELL 19(1) 154-154 2011年1月
Bone Marrow Derived Lin-Cd44hisca1-Ckit+CD34-Can Give Rise to Mesenchymal Stem Cells and Delay Progression to Dysplasia in a Murine Helicobacter Model of Gastric Cancer

Sheng-Wen Wang, Samuel Asfaha, Tomoyuku Okumura, Kelly S. Betz, Sureshkumar Muthupalani, Shuiping Tu, Shigeo Takaishi, Guangchun Jin, Xiangdong Yang, Deng-Chyang Wu …

GASTROENTEROLOGY 136(5) A10-A10 2009年5月
Mucous Metaplasia Confers An ER Stress in Helicobacter-Related Gastric Carcinogenesis

Mhairi C. Baird, Ian Clark, Masanobu Oshima, Timothy C. Wang, Shigeo Takaishi, Doug R. Taupin

GASTROENTEROLOGY 136(5) A615-A615 2009年5月
Global Loss of DNA Methylation and Decrease in Methyl Donors Correlates with Progression in a Transgenic Model of Gastric Cancer

Tamas A. Gonda, Mary V. Gamble, Kyoung J. Sohn, Shigeo Takaishi, Young-In J. Kim, Timothy C. Wang, Benjamin Tycko

GASTROENTEROLOGY 136(5) A138-A139 2009年5月
Identification of a specific bone marrow-derived cell (BMDC) subset that can contribute to the gastric epithelium

Tomoyuki Okumura, Shigeo Takaishi, Sheng-Wen Wang, Shui Ping Tu, Vivian Ng, Russell Ericksen, Anil K. Rustgi, Timothy C. Wang

GASTROENTEROLOGY 134(4) A95-A95 2008年4月
Establishment of a mouse model to study the in vivo regulation of histidine decarboxylase (HDC) gene expression

Walden Ai, Xiangdong Yang, Shigeo Takaishi, Benjamin Shykind, Frederic Marrache, Shuiping Tu, Kelly S. Betz, Timothy C. Wang

GASTROENTEROLOGY 134(4) A249-A249 2008年4月
Activation of T lymphocytes and macrophage contributes to IL-I beta-induced gastric inflammation and carcinogenesis

Shuiping Tu, Guanglin Cui, Shigeo Takaishi, Govind Bhagat, Evelyn A. Kurt-Jones, James G. Fox, Timothy C. Wang

GASTROENTEROLOGY 134(4) A133-A133 2008年4月
Altered gastric cell lineage differentiation and emergence of spasmolytic polypeptide expressing metaplasia (SPEM) after acute oxyntic atrophy in histidine decarboxylase deficient (HDC-Ko) mice

Koji Nozaki, Shigeo Takaishi, Timothy C. Wang, James R. Goldenring

GASTROENTEROLOGY 134(4) A708-A708 2008年4月
K-RAS mutation in stem/progenitor cell fraction of gastric epithelium results in early onset of gastric dysplasia with expansion of a candidate stem cell fraction

Tomoyuki Okumura, Shigeo Takaishi, Sheng-Wen Wang, Russell Ericksen, Wataru Shibata, Arlin B. Rogers, Barry H. Rickman, James G. Fox, Anil K. Rustgi, Timothy C. Wang

GASTROENTEROLOGY 134(4) A95-A95 2008年4月

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高石繁生

基本情報

研究キーワード

研究分野

論文

MISC

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