1999年5月
Inhibition of liver metastases from neuraminidase-treated Colon 26 cells by an anti-Thomsen-Friedenreich-specific monoclonal antibody
TUMOR BIOLOGY
- ,
- ,
- ,
- 巻
- 20
- 号
- 3
- 開始ページ
- 139
- 終了ページ
- 146
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000030056
- 出版者・発行元
- KARGER
Thomsen-Friedenreich antigen (TF; Gal beta 1-3GalNAc alpha 1-) is expressed on many human carcinomas. Evidence suggests that TF-carrying tumor cells specifically bind asialoglycoprotein receptors on hepatocytes resulting in metastasis formation in the liver. We used an animal model to examine the feasibility of preventing metastasis formation by an antibody to TF. Treatment of Colon 26 cells with neuraminidase led to the exposure of TF, and consequently to a higher frequency of liver metastases in syngeneic Balb/c mice. This could be prevented by an antibody to TF (A78-G/A7), but not by a control antibody. The results may open up a new strategy for the prophylaxis of metastatic spread to the liver.
- リンク情報
- ID情報
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- DOI : 10.1159/000030056
- ISSN : 1010-4283
- PubMed ID : 10213921
- Web of Science ID : WOS:000080021700003