論文

査読有り
1994年10月

EFFECT OF PACKED RED-CELL AND WHOLE-BLOOD TRANSFUSION ON LIVER-ASSOCIATED IMMUNE FUNCTION

AMERICAN JOURNAL OF SURGERY
  • K OKUNO
  • ,
  • M OZAKI
  • ,
  • H SHIGEOKA
  • ,
  • NAKAJIMA, I
  • ,
  • K NAKAMURA
  • ,
  • T HIROHATA
  • ,
  • H JINNAI
  • ,
  • M YASUTOMI

168
4
開始ページ
340
終了ページ
344
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
CAHNERS PUBL CO

In order to clarify the effect of allogeneic blood transfusion on liver metastases from primary cancer, liver-associated immune function after blood transfusion was evaluated in a muring model. Hepatic sinusoidal lymphocytes (HSL) were strongly cytotoxic to conventional natural killer cell-sensitive target (YAC-1), as well as to natural killer cell-resistant solid adeno-carcinoma cells (colon 26), compared with splenic lymphocytes. Allogeneic whole blood transfusion strikingly suppressed the cytotoxic activities of HSL. Red blood cell transfusions also suppressed cytotoxicity to the same degree.
In an animal model, allogeneic transfusion increased the rate of liver metatases. Flow cytometric analysis showed that transfusion caused a temporary decrease in the class II antigen positive cell fraction, mainly Kupffer's cells. This phenomenon occurred in parallel with changes in hepatic antitumor activity, indicating the possible importance of the involvement of Kupffer's cell in the development of the killer activity of HSL. These results suggest that blood transfusion may be a significant risk factor for hepatic metastasis by transiently suppressing the immunocompetence of the liver.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/7943591
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994PK38700013&DestApp=WOS_CPL
ID情報
  • ISSN : 0002-9610
  • PubMed ID : 7943591
  • Web of Science ID : WOS:A1994PK38700013

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