shigeru morinobu

Profile Information

Affiliation: -

Degree: 医学博士(山形大学)

J-GLOBAL ID: 201101012275272099
researchmap Member ID: B000002404

Research Interests

Research Areas

Life sciences / Psychiatry /

Research History

Apr, 2017 - Present

School of Health Science and Social Welfare, Kibi International University
Sep, 2013 - Mar, 2017

Medical School, Kochi University
Apr, 2011 - Aug, 2013

特任教授, 精神神経医科学, 広島大学大学院医歯薬学研究院
2008 - 2011

准教授, 広島大学医歯薬学総合研究科
2004 - 2007

助教授, 広島大学医歯薬学総合研究科
2007

准教授, 広島大学医歯薬学総合研究科・大学院
2006

助教授, 広島大学大学院医歯薬学総合研究科
2002 - 2005

助教授, 広島大学医歯薬学総合研究科・大学院
2003

Hiroshima University
1999 - 2002

Faculty of Medicine, Hiroshima University
1998 - 1999

Undergraduate School of Medicine, Shiga University of Medical Science
1994 - 1998

Faculty of Medicine, Yamagata University
1989

Faculty of Medicine, Yamagata University
1989

教授, 山形大学医学部付属病院精神神経医学講座
1988

助手, 山形大学医学部付属病院・精神神経科

Papers

122

Important factors in the observation dimensions of high school Yogo teachers to detect prodromal symptoms of mental health issues in adolescents

Yukiko Masumoto, Shigeru Morinobu, Koichiro Fujimaki, Keiko Kasagi

Journal of Affective Disorders Reports, 5 100173-100173, Jul, 2021
Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD

Jun Omura, Manabu Fuchikami, Motoaki Araki, Tatsuhiro Miyagi, Yasumasa Okamoto, Shigeru Morinobu

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 108 110090-110090, Jun, 2021
Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine.

Kouichi Hashimoto, Yosuke Yamawaki, Kenji Yamaoka, Takayuki Yoshida, Kana Okada, Wanqin Tan, Miwako Yamasaki, Yoshiko Matsumoto-Makidono, Reika Kubo, Hisako Nakayama …

Brain communications, 3(4) fcab285, 2021
The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder.

Motoaki Araki, Manabu Fuchikami, Jun Omura, Tatsuhiro Miyagi, Nobuyuki Nagashima, Yasumasa Okamoto, Shigeru Morinobu

Psychopharmacology, 237(7) 2125-2137, Apr 24, 2020 Peer-reviewed
Structural variation in the glycogen synthase kinase 3β and brain-derived neurotrophic factor genes in Japanese patients with bipolar disorders.

Yosuke Suga, Keiichiro Yoshimoto, Shusuke Numata, Shinji Shimodera, Shogo Takamura, Naoto Kamimura, Ken Sawada, Hiromitsu Kazui, Tetsuro Ohmori, Shigeru Morinobu

Neuropsychopharmacology reports, 40(1) 46-51, Mar, 2020 Peer-reviewed
Maximum Credibility Voting (MCV) An Integrative Approach for Accurate Diagnosis of Major Depressive Disorder from Clinically Readily Available Data.

Yu Shimizu, Junichiro Yoshimoto, Masahiro Takamura, Go Okada, Tomoya Matsumoto, Manabu Fuchikami, Satoshi Okada, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki …

1023-1032, 2020
The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood.

Kazushige Ihara, Manabu Fuchikami, Masahiro Hashizume, Satoshi Okada, Hisashi Kawai, Shuichi Obuchi, Hirohiko Hirano, Yoshinori Fujiwara, Mitsugu Hachisu, Kim Hongyong …

International journal of geriatric psychiatry, 33(10) 1312-1318, Oct, 2018 Peer-reviewed
Musical disability in children with autism spectrum disorder

Satoko Sota, Sanae Hatada, Kinji Honjyo, Tomoyuki Takatsuka, William G. Honer, Shigeru Morinobu, Ken Sawada

Psychiatry Research, 267 354-359, Sep 1, 2018 Peer-reviewed
Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder.

Kataoka T, Fuchikami M, Nojima S, Nagashima N, Araki M, Omura J, Miyagi T, Okamoto Y, Morinobu S

Genes Brain and Behavior, 33(10) e12520-1318, Sep, 2018 Peer-reviewed
Musical deficits and cortical thickness in people with schizophrenia

Ryosuke Fujito, Masayoshi Minese, Sanae Hatada, Naoto Kamimura, Shigeru Morinobu, Donna J. Lang, William G. Honer, Ken Sawada

Schizophrenia Research, 197 233-239, Jul 1, 2018 Peer-reviewed
Sex differences in auditory verbal hallucinations in early, middle and late adolescence: results from a survey of 17 451 Japanese students aged 12-18 years.

Yoko Morokuma, Kaori Endo, Atushi Nishida, Syudo Yamasaki, Shuntaro Ando, Yuko Morimoto, Miharu Nakanishi, Yuji Okazaki, Toshi A Furukawa, Shigeru Morinobu …

BMJ open, 7(5) e015239, Jun 1, 2017 Peer-reviewed
Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication

Shogo Takamura, Aya Ikeda, Kenya Nishioka, Hirokazu Furuya, Mari Tashiro, Takashi Matsushima, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Shigeru Morinobu …

PARKINSONISM & RELATED DISORDERS, 25(4) 108-109, Apr, 2016 Peer-reviewed
Cortical activation changes and sub-threshold affective symptoms are associated with social functioning in a non-clinical population: A multi-channel near-infrared spectroscopy study

Koichiro Fujimaki, Hidenori Takemoto, Shigeru Morinobu

PSYCHIATRY RESEARCH-NEUROIMAGING, 248 73-82, Feb, 2016 Peer-reviewed
老齢期に脊髄前角細胞が多く残されると筋の収縮能力を維持するのか？

武本秀徳, 今北英高, 金村尚彦, 国文貴徳, 藤巻康一郎, 松本知也, 森信繁

理学療法学Supplement, 2015 467-467, 2016
Comparing the driving behaviours of individuals with frontotemporal lobar degeneration and those with Alzheimer's disease

Ryoko Fujito, Naoto Kamimura, Manabu Ikeda, Asuka Koyama, Shinji Shimodera, Shigeru Morinobu, Shimpei Inoue

PSYCHOGERIATRICS, 16(1) 27-33, Jan, 2016 Peer-reviewed
The potential use of histone deacetylase inhibitors in the treatment of depression

Manabu Fuchikami, Shigeto Yamamoto, Shigeru Morinobu, Satoshi Okada, Yosuke Yamawaki, Shigeto Yamawaki

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64(1) 320-324, Jan, 2016 Peer-reviewed
Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation

Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku …

EPIGENETICS, 10(2) 135-141, Feb, 2015 Peer-reviewed
Association between Sub-Threshold Affective Symptoms and Prefrontal Activation in Non-Clinical Population―An NIRS Study

Fujimaki K, Takemoto H, Morinobu S

Psychology, 5 1024-1034, Jul, 2014 Peer-reviewed
Environmental Sounds Enhance Cortical Responses Related to a Serial Arithmetic Task

Fujimaki K, Takemoto H, Morinobu S

Psychology, 5 828-839, Jun, 2014 Peer-reviewed
SUNoD 大うつ病に対する新規抗うつ剤の最適使用戦略を確立するための大規模無作為割り付け比較試験

古川壽亮, 下寺信次, 明智龍男, 山田光彦, 渡辺範雄, 稲垣正俊, 三木和平, 米本直裕, 小川雄右, 田近亜蘭 …

精神医学, 56(6) 477-489, Jun, 2014

Misc.

276

Predictors of hypomanic and/or manic switch among patients initially diagnosed with unipolar major depression during acute-phase antidepressants treatment

Tatsuo Akechi, Tadashi Kato, Norio Watanabe, Shiro Tanaka, Toshi A. Furukawa, Toshi A. Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Masatoshi Inagaki …

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 73(2) 90-91, Feb, 2019
難治性うつ病として治療されていたPTSDの1例

須賀楓介, 土居江里奈, 赤松正規, 森信繁

精神神経学雑誌, 120(2) 147-147, Feb, 2018
大学病院における基幹型認知症疾患医療センターの役割と課題(1)

中村京子, 上村直人, 今城由里子, 森澤陽子, 古谷博和, 下寺信次, 森信繁

精神神経学雑誌, 120(2) 150-150, Feb, 2018
大学病院における基幹型認知症疾患医療センターの役割と課題受診目的からの分析と傾向

上村直人, 中村京子, 今城由里子, 森澤陽子, 古谷博和, 下寺信次, 森信繁

精神神経学雑誌, 120(2) 150-150, Feb, 2018
妄想を伴った神経核内封入体病の1例

高村祥吾, 赤松正規, 上村直人, 下寺信次, 森信繁, 宮本由賀, 古谷博和

精神神経学雑誌, 120(2) 153-153, Feb, 2018
GSK3beta遺伝子及びBDNF遺伝子のCNVによる双極性障害のリチウム治療反応性の研究

森信繁, 吉本啓一郎, 須賀楓介, 上村直人, 下寺信次, 沼田周助, 大森哲郎

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回 173-173, Sep, 2017
GSK3β遺伝子及びBDNF遺伝子のCNVによる双極性障害のリチウム治療反応性の研究

森信繁, 吉本啓一郎, 須賀楓介, 上村直人, 下寺信次, 沼田周助, 大森哲郎

先進医薬研究振興財団研究成果報告集, 2016年度 50-51, Mar, 2017
Diagnostic biomarker of major depression based on DNA meth-ylation

Shigeru Morinobu

Seikagaku, 89(1) 94-97, 2017
認知症スクリーニングとしての逆指合わせテスト(Reverse Fox Test)の有用性

古谷博和, 森田ゆかり, 大崎康史, 上村直人, 森信繁, 藤井直樹

神経治療学, 33(5) S229-S229, Oct, 2016
老齢期に脊髄前角細胞が多く残されると筋の収縮能力を維持するのか?

武本秀徳, 今北英高, 金村尚彦, 国文貴徳, 藤巻康一郎, 松本知也, 森信繁

理学療法学, 43(Suppl.2) O-3, Oct, 2016
物忘れ外来におけるうつ状態の鑑別の重要性について認知症以外の物忘れを主訴とするうつ状態の鑑別を要した2事例からの考察

上村直人, 須賀楓介, 土居江里奈, 赤松正規, 下寺信次, 森信繁

日本社会精神医学会雑誌, 25(3) 272-273, Aug, 2016
老齢期に脊髄前角細胞が多く残されると筋の収縮能力を維持するのか?

武本秀徳, 今北英高, 金村尚彦, 国文貴徳, 藤巻康一郎, 松木知也, 森信繁

日本基礎理学療法学雑誌, 20(1) 123-123, Aug, 2016
The limitation and newer possibility of pharmacotherapy in major depression

19(7) 927-934, Jul, 2016
The effects of brain-derived neurotrophic factor (BDNF) micro-infusion on the impaired fear extinction of the animal model of PTSD.

Manabu Fuchikami, Tsutomu Kataoka, Tatsuhiko Miyagi, Shigeru Morinobu, Noboyuki Nagashima, Satoshi Okada, Shigeto Yamawaki

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19 140-141, Jun, 2016
認知機能低下と妄想を呈した神経核内封入体病(NIID)の一例

高村祥吾, 赤松正規, 上村直人, 下寺信次, 森信繁, 宮本由賀, 古谷博和, 植田明彦, 曽根淳, 祖父江元 …

精神神経学雑誌, (2016特別号) S628-S628, Jun, 2016
高知県認知症疾患医療センターの取組みと課題地域特性を活かしたシステム作りを目指して

上村直人, 澤田健, 諸隈陽子, 吉本啓一郎, 大久保晃, 下寺信次, 古谷博和, 森信繁

高知県医師会医学雑誌, 21(1) 84-91, Mar, 2016
難治性うつ病に対する電気けいれん治療によるBDNF遺伝子メチル化と安静時fMRIの変動

森信繁, 須賀楓介, 澤田健, 木村岳裕, 門田宏, 中原潔, 岩田誠, 淵上学, 岡田怜, 岡田剛 …

先進医薬研究振興財団研究成果報告集, 2015年度 52-53, Mar, 2016
PTSDの病態形成過程におけるGlucocorticoid受容体(GR)活性化を介したBcl-2/Bax遺伝子の発現変化の検討

長嶋信行, 淵上学, 野嶌真士, 片岡努, 岡田怜, 森信繁, 山脇成人

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回 193-193, Sep, 2015
PTSD動物モデルであるSPS負荷ラット海馬のspine障害についての解析

森信繁, 武本秀徳, 片岡努, 長嶋信行, 岡田怜, 淵上学, 山本茂人, 藤巻康一郎, 山脇成人

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回 186-186, Sep, 2015
PTSDモデルラットにおける恐怖記憶の消去障害に対する脳由来神経栄養因子Brain-Derived Neurotrophic Factor(BDNF)脳局所投与の効果の検討

片岡努, 淵上学, 長嶋信行, 野嶌真士, 岡田怜, 森信繁, 山脇成人

日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回 195-195, Sep, 2015

Research Projects

DNAメチル化障害とその量的形質遺伝子座を用いた健康支援研究のモデル開発

科学研究費助成事業挑戦的研究(開拓), 挑戦的研究(開拓), 日本学術振興会, Jun, 2022 - Mar, 2025

井原一成, 中路重之, 森信繁, 谷澤薫平
Elucidation of the involvement of RNA methylation in impairment of fear memory extinction in PTSD and development of a new therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Combination treatment of stem cell and exercise therapies in a Wistar Kyoto rat model of traumatic brain injury

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

TAJIRI NAOKI
Development of newer animal model, biomarker, and treatment of depression by regulation of BDNFgene methylation using genome editing

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Morinobu Shigeru
Driving assessment in DLB

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

KAMIMURA Naoto
A longitudinal study of epigenetic epidemiology for the primary and secondary prevention of elderly depression

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

IHARA Kazushige
Development of the therapeutic biomarker in bipolar disorder using CNV and methylation of target genes of mood stabilizers

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Morinobu Shigeru
Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Sakai Norio, HIDE IZUMI, TANAKA SHIGERU, MORINOBU SHIGERU, SHIRAFUJI TOSHIHIKO
Integrating molecular and psychosocial approach for assisting adolescent mind development and self-regulation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Kasai Kiyoto, TANAKA Satoshi, YAMAZAKI Syudo, MURAI Toshiya, YAMAWAKI Shigeto, OKAMOTO Yasumasa, YAHATA Noriaki, TAKIZAWA Ryu, ISHIGAKI Takuma, MORINOBU Shigeru, TAKEBAYASHI Minoru, MIYATA Jun, FUKUI Hiroki, OZAKI Norio
エピジェネティクスと組織化学的手法によるPTSDの病態解明と予防法の開発

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

森信繁
A study on brain mechanisms of emotional control and restoring mechanisms to their disturbance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SHIGETO Yamawaki, OKAMOTO Yasumasa, YOSHINO Atsuo, NAKAO Takashi, MORINOBU Shigeru, YAMASAHITA Hidehisa
Epidemiologic study on epigenetics related to BDNF for primary and secondary prevention of depression in the elderly

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

IHARA Kazushige, MORINOBU Shigeru, YOSHIDA Hideyo, OBUCHI Shuichi
Can exercise maintain and/or improve age-related changes in function and morphology of nervous system responsible for postural and locomotor control?

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

TAKEMOTO Hidenori, KANEMURA Naohiko, FUJIMAKI Koichiro, MORINOBU Shigeru, IMAGITA Hidetaka, MATSUMOTO Tomoya
Development of the biomarker for suicide prediction using the methylation at the gene promoters

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2013

MORINOBU Shigeru
The role of pro-domain BDNF in depression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, 2009 - 2010

MATSUMOTO Tomoya, YAMAWAKI Shigeto, MORINOBU Shigeru, KOJIMA Masami, TAKAHASHI Masami
Elucidation of pathophysiology of refractory depression and development of newer treatment based on the disturbance of spine dynamics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2009

MORINOBU Shigeru
エピジェネティクスと大脳白質微細構造によるうつ病発症・難治化の機序解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2008 - 2009

森信繁, 宮本和明, 福田浩
クロマチン・リモデニングからみた新たなうつ病の病態解明と治療法開発の糸口発見

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2008 - 2009

山脇成人, 森信繁
The study of vulnerability for PTSD and the development of newer treatment using PTSD model rats

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

KOZURU Toshiro, MORINOBU Shigeru, YAMAMOTO Shigeto, SHIRO Takei, IWAMOTO Yasuyuki, IMANAKA Akihiro, MATSUKI Aya
エピジェネティクスによるうつ病発症・難治化の機序解明

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2006 - 2007

森信繁, 宮本和明

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