Shigetsugu HATAKEYAMA

J-GLOBAL         Last updated: Dec 25, 2018 at 12:48
 
Avatar
Name
Shigetsugu HATAKEYAMA
Affiliation
Faculty of Medicine and Graduate School of Medicine, Hokkaido University
Section
Department of Biochemistry
Job title
Professor
Degree
M.D., Ph.D.

Research Interests

 
 

Academic & Professional Experience

 
Apr 2011
 - 
Today
Director, Central Institute of Radioisotope, Hokkaido University
 
Apr 2017
 - 
Today
Vice Dean, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
 
Apr 2017
 - 
Today
Professor, Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
 
Apr 2014
 - 
Mar 2017
Adviser to the President, Hokkaido University
 
Apr 2013
 - 
Mar 2014
Executive Adviser, Executive Office for Research Strategy, Hokkaido University
 
Sep 2011
 - 
Aug 2013
Director, Institute for Animal Experimentationhool of Medicine, Hokkaido University Graduate School of Medicine
 
Jul 2004
 - 
Today
Professor, Department of Biochemistry, Hokkaido University Graduate School of Medicine
 
Nov 2000
 - 
Jun 2004
Associate Professor, Medical Instutute of Bioregulation, Kyushu University
 
Mar 1997
 - 
Oct 2000
Research associate, Medical Institute of Bioregulation, Kyushu University
 
Jun 1995
 - 
Feb 1997
NCI, NIH
 
Apr 1994
 - 
May 1995
Post-doc, School of Medicine, Washington University
 

Published Papers

 
Yanagi T, Watanabe M, Hata H, Kitamura S, Imafuku K, Yanagi H, Homma A, Wang L, Takahashi H, Shimizu H, Hatakeyama S
Cancer research      Nov 2018   [Refereed]
Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T
Circulation   138(18) 2064-2066   Oct 2018   [Refereed]
Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S, Hu B, Cheng SY, Feng H
Cancer research   78(7) 1792-1804   Apr 2018   [Refereed]
Yaguchi H, Yabe I, Takahashi H, Watanabe M, Nomura T, Kano T, Watanabe M, Hatakeyama S
Journal of neurology   265(4) 962-965   Apr 2018   [Refereed]
Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H
Scientific reports   8(1) 819   Jan 2018   [Refereed]
Yaguchi H, Yabe I, Takahashi H, Watanabe M, Nomura T, Kano T, Matsumoto M, Nakayama KI, Watanabe M, Hatakeyama S
Biochemical and biophysical research communications   494(1-2) 234-241   Dec 2017   [Refereed]
Watanabe M, Hatakeyama S
Cellular & molecular immunology      Sep 2017   [Refereed]
Hatakeyama S
Trends in biochemical sciences      Jan 2017   [Refereed][Invited]
Masashi Watanabe, Shigetsugu Hatakeyama
Journal of Biochemistry      Jan 2017   [Refereed][Invited]
Ibata M, Iwasaki J, Fujioka Y, Nakagawa K, Darmanin S, Onozawa M, Hashimoto D, Ohba Y, Hatakeyama S, Teshima T, Kondo T
Cancer science      Dec 2016   [Refereed]
Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S
Journal of molecular and cellular cardiology      Sep 2016   [Refereed]
Anwar D, Takahashi H, Watanabe M, Suzuki M, Fukuda S, Hatakeyama S
Biochimica et biophysica acta   1859(8) 975-982   Aug 2016   [Refereed]
Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K
Mucosal immunology      Jul 2016   [Refereed]
Otomo K, Amengual O, Fujieda Y, Nakagawa H, Kato M, Oku K, Horita T, Yasuda S, Matsumoto M, Nakayama KI, Hatakeyama S, Koike T, Atsumi T
Lupus      Mar 2016   [Refereed]
Hatakeyama S
Expert opinion on therapeutic targets   1-4   Feb 2016   [Refereed]
Fujieda Y, Amengual O, Matsumoto M, Kuroki K, Takahashi H, Kono M, Kurita T, Otomo K, Kato M, Oku K, Bohgaki T, Horita T, Yasuda S, Maenaka K, Hatakeyama S, Nakayama KI, Atsumi T
Rheumatology (Oxford, England)      Feb 2016   [Refereed]
Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, Hatakeyama S
Cellular and molecular life sciences : CMLS      Sep 2015   [Refereed]
Masuda Y, Takahashi H, Hatakeyama S
Biochimica et biophysica acta   1853(10 Pt A) 2296-2305   Jun 2015   [Refereed]
Masuda, Y., Takahashi, H., Sato, S., Tomonori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W. and Hatakeyama, S.
Nature Communications   6 7299   Jun 2015   [Refereed]
Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, Mizushima W, Tanaka K, Hatakeyama S
eLife   4 e05615   Apr 2015   [Refereed]
Takahashi H, Takigawa I, Watanabe M, Anwar D, Shibata M, Tomomori-Sato C, Sato S, Ranjan A, Seidel CW, Tsukiyama T, Mizushima W, Hayashi M, Ohkawa Y, Conaway JW, Conaway RC, Hatakeyama S
Nature communications   6 5941   Jan 2015   [Refereed]
Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S
Molecular and cellular biology   35(11) 2007-2023   Jun 2015   [Refereed]
Kameda Y, Takahata M, Mikuni S, Shimizu T, Hamano H, Angata T, Hatakeyama S, Kinjo M, Iwasaki N
Bone   71 217-226   Feb 2015   [Refereed]
Nakamaru Y, Takagi D, Homma A, Hatakeyama S, Fukuda S
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery   152 48-52   Jan 2015   [Refereed]
Kanno Y, Mitsui T, Kitta T, Moriya K, Tsukiyama T, Hatakeyama S, Nonomura K
Neurourology and urodynamics      Jan 2015   [Refereed]
Kanno Y, Watanabe M, Kimura T, Nonomura K, Tanaka S, Hatakeyama S
Acta histochemica   116 708-712   Jun 2014   [Refereed]
Yabe I, Tanino M, Yaguchi H, Takiyama A, Cai H, Kanno H, Takahashi I, Hayashi YK, Watanabe M, Takahashi H, Hatakeyama S, Tanaka S, Sasaki H
Clinical neurology and neurosurgery   127 10-12   Dec 2014   [Refereed]
Ai L, Kim WJ, Alpay M, Tang M, Pardo CE, Hatakeyama S, May WS, Kladde MP, Heldermon CD, Siegel EM, Brown KD
Cancer research      Jun 2014   [Refereed]
Sato T, Takahashi H, Hatakeyama S, Iguchi A, Ariga T
Oncogene      Mar 2014   [Refereed]
Yaguchi H, Yabe I, Takahashi H, Okumura F, Takeuchi A, Horiuchi K, Kano T, Kanda A, Saito W, Matsumoto M, Nakayama KI, Hatakeyama S, Sasaki H
Journal of neurology   261 224-226   Jan 2014   [Refereed]
Kameda Y, Takahata M, Komatsu M, Mikuni S, Hatakeyama S, Shimizu T, Angata T, Kinjo M, Minami A, Iwasaki N
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research      May 2013   [Refereed]
Ichimura T, Taoka M, Shoji I, Kato H, Sato T, Hatakeyama S, Isobe T, Hachiya N
Journal of cell science   126(9) 2014-2026   Feb 2013   [Refereed]
Okumura F, Okumura AJ, Uematsu K, Hatakeyama S, Zhang DE, Kamura T
The Journal of biological chemistry      Dec 2012   [Refereed]
[New findings of ubiquitin-proteasome system from yeast to higher organisms].
Yamaguchi J, Hatakeyama S
Seikagaku. The Journal of Japanese Biochemical Society   84 407-408   Jun 2012   [Refereed]
Kondo T, Watanabe M, Hatakeyama S
Biochemical and biophysical research communications   422 501-507   Jun 2012   [Refereed]
Shibata M, Sato T, Nukiwa R, Ariga T, Hatakeyama S
Biochemical and biophysical research communications   423 104-109   Jun 2012   [Refereed]
Sato T, Okumura F, Ariga T, Hatakeyama S
Journal of cell science      Feb 2012   [Refereed]
Tsukiyama T, Matsuda-Tsukiyama M, Bohgaki M, Terai S, Tanaka S, Hatakeyama S
Molecular medicine (Cambridge, Mass.)      Feb 2012   [Refereed]
Yaguchi H, Okumura F, Takahashi H, Kano T, Kameda H, Uchigashima M, Tanaka S, Watanabe M, Sasaki H, Hatakeyama S
The Journal of biological chemistry      Feb 2012   [Refereed]
Sato T, Okumura F, Iguchi A, Ariga T, Hatakeyama S
Biochemical and biophysical research communications   417(1) 594-600   Jan 2012   [Refereed]
Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S
Biochimica et biophysica acta   1813 1784-1792   Oct 2011   [Refereed]
Hatakeyama S
Nature reviews. Cancer   11 792-804   Oct 2011   [Refereed]
Sato T, Okumura F, Kano S, Kondo T, Ariga T, Hatakeyama S
Journal of cell science   124(20) 3492-3502   Oct 2011   [Refereed]
Noguchi K, Okumura F, Takahashi N, Kataoka A, Kamiyama T, Todo S, Hatakeyama S
Carcinogenesis   32(7) 995-1004   Jul 2011   [Refereed]
Okumura F, Yoshida K, Liang F, Hatakeyama S
Molecular and cellular biochemistry   352(1-2) 163-172   Jun 2011   [Refereed]
Sho T, Tsukiyama T, Sato T, Kondo T, Cheng J, Saku T, Asaka M, Hatakeyama S
Biochimica et biophysica acta   1813 1245-1253   Jun 2011   [Refereed]
Okumura F, Kameda H, Ojima T, Hatakeyama S
Biochemical and biophysical research communications   395(3) 352-355   Apr 2010   [Refereed]
Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T
Molecular immunology   47(6) 1283-1291   Mar 2010   [Refereed]
Kikuchi M, Okumura F, Tsukiyama T, Watanabe M, Miyajima N, Tanaka J, Imamura M, Hatakeyama S
Biochimica et biophysica acta   1793 1828-1836   Dec 2009   [Refereed]
Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M
Developmental cell   17(6) 800-810   Dec 2009   [Refereed]

Misc

 
松田拳, 高木賢治, 畠山鎮次, 水島恒裕
日本結晶学会年会講演要旨集   2018 67   Nov 2018
免疫介在性小脳失調症例で同定した抗Sez6l2抗体はSez6l2とGluR1の結合を阻害することにより病原性を呈する
矢口 裕章, 高橋 秀尚, 矢部 一郎, 渡辺 雅彦, 畠山 鎮次
神経免疫学   22(1) 130-130   Oct 2017
高橋秀尚, 柴田美音, 瀧川一学, 渡部昌, 築山忠維, 山本淳一, 山口雄輝, 藤井聡, 飯田緑, RANJAN Amol, SATO Shigeo, TOMOMORI‐SATO Chieri, CONAWAY Joan, CONAWAY Ronald, 畠山鎮次
日本生化学会大会(Web)   90th ROMBUNNO.4P2T15‐06(3P‐0635) (WEB ONLY)   2017
吉田一彦, 吉田一彦, 谷野美智枝, 堀井理絵, 木村太一, 津田真寿美, 近藤恒徳, 秋山太, 畠山鎮次, 田邉一成, 田中伸哉
日本泌尿器科学会東部総会プログラム・抄録集   82nd 222   2017
渡部昌, 高橋秀尚, 畠山鎮次
日本内分泌学会雑誌   92(1) 201   Apr 2016

Books etc

 
Medical Biochemistry
Shigetsugu HATAKEYAMA (Part:Joint Translation, 30 Role of the Liver in Metabolism)
Dec 2018   
Advances in Medicine and Biology. Volume 120
Masashi Watanabe, Shigetsugu HATAKEYAMA (Part:Joint Work, Ubiquitin-Conjugating Enzymes (E2s))
Nova Science Publishers   2017   
PSA and Prostate Cancer
Shigetsugu HATAKEYAMA (Part:Contributor, Molecular mechanism of PSA expression in prostate cancer cells)
Nova Science Publishers   2010   
Handbook of Prostate Cancer Cell Research: Growth, Signalling and Survival
Shigetsugu HATAKEYAMA (Part:Contributor, Post-translational regulation of androgen receptor in proliferation of prostate cancer cells)
Nova Science Publishers   2009   
Ubiquitin-proteasome system (Methods in Enzymology)
Shigetsugu HATAKEYAMA (Part:Contributor, Mapping of ubiquitination sites on target proteins)
Academic press   2005   

Conference Activities & Talks

 
Functions of TRIM family proteins in metabolism and carcinogenesis [Invited]
Shigetsugu HATAKEYAMA
International Symposium for New Aspects of the Ubiquitin Research   6 Dec 2016   
Pleomorphic modes regulation of diverse biological phenomena mediated by ubiquitin
Shigetsugu HATAKEYAMA
1 Dec 2016   
Regulation of cellular functions by TRIM proteins [Invited]
Shigetsugu HATAKEYAMA
The 35th Naito Conference   10 Jul 2013   
TRIM proteins in inflammation and carcinogenesis [Invited]
Shigetsugu HATAKEYAMA
2nd international symposium: Infection-related cancers   12 May 2012   
TRIM proteins and cancers [Invited]
Shigetsugu HATAKEYAMA
24 Sep 2010   

Association Memberships

 
 

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2006 - 2010    Investigator(s): Kamura TAKUMI
Ubiquitylation and subsequent proteasomal degradation of regulatory proteins control a variety of cellular processes. The ubiquitin conjugation to target proteins is processed by three enzymes, E1, E2, and E3. The E3s are responsible for recognizi...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Satoshi FUKUDA
We analyzed the function of Ubiquitin in head and neck cancer. We considered TRIM32 and UBE2Q2 as a important factor to control the treatment of advanced head and neck Cancer.
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2006 - 2007    Investigator(s): Shigetsugu HATAKEYAMA
Ubiquitination is a versatile post-translational modification mechanism used by eukaryotic cells mainly to control protein levels through proteasome-mediated proteolysis. Ubiquitin conjugation is achieved by several enzymes that act in concert, a ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Takumi KAMURA
The cyclin-dependent kinase (CDK) inhibitor p27 is degraded at the G(0)-G(1) transition of the cell cycle by the ubiquitin-proteasome pathway in a Skp2-independent manner. We recently identified a novel ubiquitin ligase, KPC (Kip1 ubiquitylation-p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Shigetsugu HATAKEYAMA
This application is to analyze comprehensively about post-translational modification regarding to phosphorylation and ubiquitylation using affinity-chromatography. The system we analyzed is signal transduction system of antigen receptor signals in...