Shigeyoshi Itohara

J-GLOBAL         Last updated: Oct 12, 2018 at 19:00
 
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Name
Shigeyoshi Itohara
Affiliation
RIKEN
Degree
Ph.D.(University of Tokyo)
ORCID ID
0000-0002-2410-9989

Profile

Using mouse genetic methods, he aims to elusidate molecular and circuit mechanisms underlying attention and impulsivity.

Academic & Professional Experience

 
Apr 2018
 - 
Today
Team Leader, Laboratory for Behavioral Genetics, RIKEN Center for Brain Science
 
Apr 2007
 - 
Mar 2018
Visiting Professor, Department of Life Science and Medical Bio-Science, Waseda University
 
Apr 2007
 - 
Mar 2017
Adjunctive Professor, Graduate School of Agricultural and Life Sciences, University of Tokyo
 
Apr 1992
 - 
Mar 1993
Laboratory Head, Laboratory of Immunogenetics, National Institute for Animal Health
 
Apr 1991
 - 
Mar 1992
Senior Researcher, National Institute for Animal Health
 

Published Papers

 
An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents.
Zhang Q, Kobayashi Y, Goto H, Itohara S.
doi: 10.3791/57895.   Aug 2018   [Refereed][Invited]
Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage.
Masuda A, Kobayashi Y, Itohara S.
J. Vis. Exp.   doi: 10.3791/58009.   Aug 2018   [Refereed][Invited]
Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K.
Communications Biology   doi: 10.1038/s42003-018-0099-2   Jul 2018   [Refereed]
Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.
Kato TM, Kubota-Sakashita M, Fujimori-Tonou N, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T.
Molecular Psychiatry      Jun 2018   [Refereed]
Kuroki S, Yoshida T, Tsutsui H, Iwama M, Ando R, Michikawa T, Miyawaki A, Ohshima T, Itohara S.
Cell Reports   22(11) 2873-2885   Mar 2018   [Refereed]
Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency.
Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, Suzuki T, Tatsukawa T, Itohara S, Sakimura K, Yamakawa K.
Human Molecular Genetics   26(24) 4961-4974   Dec 2017   [Refereed]
Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma.
Shiihashi G, Ito D, Arai I, Kobayashi Y, Hayashi K, Otsuka S, Nakajima K, Yuzaki M, Itohara S, Suzuki N.
EBioMedicine   24 102-115   Oct 2017   [Refereed]
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.
Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A
Journal of Biological Chemistry   292(37) 15538-15551   Sep 2017   [Refereed]
Spinal RacGAPchimaerin is required to establish the midline barrier for proper corticospinal axon guidance.
Katori S, Noguchi-Katori Y, Itohara S, Iwasato T
Journal of Neuroscience   37(32) 7682-7699   Aug 2017   [Refereed]
Hayashi Y, Itohara S
Neuroscience research   118 1-2   May 2017   [Refereed][Invited]

Patents

 
特許JP2009051742-A; US2010242126-A1; US8337812-B2 : Agent useful for controlling axon extension for treating nerve damage disease e.g. spinal injury, comprises agent e.g. DNA or double-stranded RNA capable of stimulating or suppressing function of alpha-chimerin
INOUE H, ITOHARA S, IWASATO T, TAKAHASHI R
特許JP2005087095-A : Novel non-human animal e.g. mouse model for osteoporosis and/or craniosynostosis having defective matrix metalloprotease-2 gene, useful for evaluating effect of test substance as osteoporosis and/or craniosynostosis therapeutic agent
ITOHARA S, INOUE K
特許JP2001327289-A; CA2324167-A1 : Membrane bound type netrin, comprises hydrophobic region which can be combined to cell membrane through glycosylphosphatidylinositol at C-terminal
ITOHARA S, NAKASHIBA T, IKEDA T, TASHIRO H, HONJO T, TASHIRO K, NAKASHINBA T
特許EP1120655-A; EP1120655-A2; JP2001204475-A; CA2332657-A1; US200 : Detecting aberrant animal-derived prion gene, by introducing prion gene of an animal into a mouse to produce a prion gene modified mouse and determining whether the prion gene modified mouse exhibits a heart anomaly
ITOHARA S, ONODERA T, TSUBONE H