論文

査読有り
2016年4月

Bioactivity of sol-gel-derived TiO2 coating on polyetheretherketone: In vitro and in vivo studies

ACTA BIOMATERIALIA
  • Takayoshi Shimizu
  • ,
  • Shunsuke Fujibayashi
  • ,
  • Seiji Yamaguchi
  • ,
  • Koji Yamamoto
  • ,
  • Bungo Otsuki
  • ,
  • Mitsuru Takemoto
  • ,
  • Masako Tsukanaka
  • ,
  • Takashi Kizuki
  • ,
  • Tomiharu Matsushita
  • ,
  • Tadashi Kokubo
  • ,
  • Shuichi Matsuda

35
開始ページ
305
終了ページ
317
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.actbio.2016.02.007
出版者・発行元
ELSEVIER SCI LTD

A polyetheretherketone (PEEK) surface was modified using a sol-gel-derived TiO2 coating in order to confer bone-bonding ability. To enhance the bonding strength of the coating layer, pretreatment with either O-2 plasma or sandblasting was performed prior to sol-gel coating. Additionally, post-treatment with acid was carried out to confer apatite (calcium phosphate)-forming ability to the surface. Biomechanical and histological analyses performed using an in vivo rabbit tibia model showed that PEEK surfaces modified with sol-gel-derived TiO2 and acid post-treatment had better bone-bonding properties than uncoated PEEK surfaces. These modified surfaces also performed well in terms of their in vitro cell responses due to their modified surface chemistries and topographies. Although O-2 plasma or sandblasting treatment were, for the most part, equivocal in terms of performance, we conclude that sol-gel-derived TiO2 coating followed by acid post-treatment significantly improves the bone bonding ability of PEEK surfaces, thus rendering them optimal for their use in surgical implants.
Statement of Significance
The role of polyetheretherketone (PEEK) as an alternative biomaterial to conventional metallic implant materials has become increasingly important. However, its low bone bonding ability is yet to be resolved. This in vivo and in vitro investigation on the functionalization of PEEK surfaces highlights the utility of this material in clinical interventions that require implants, and may extend range of applications of PEEK. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 34

リンク情報
DOI
https://doi.org/10.1016/j.actbio.2016.02.007
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375162200028&DestApp=WOS_CPL

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