2003年12月
REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor
MOLECULAR AND CELLULAR BIOLOGY
- ,
- 巻
- 23
- 号
- 24
- 開始ページ
- 9025
- 終了ページ
- 9031
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/MCB.23.24.9025-9031.2003
- 出版者・発行元
- AMER SOC MICROBIOLOGY
The transcriptional repressor REST/NRSF (RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting. Using this domain as bait in a yeast two-hybrid screen, a novel protein that contains three LIM domains, putative nuclear localization sequences, protein kinase A phosphorylation sites, and a CAAX prenylation motif was isolated. This protein, which is localized around the nucleus, is involved in determining the nuclear localization of REST4 and REST/NRSF. We propose the name RILP, for REST/NRSF-interacting LIM domain protein, to label this novel protein. RILP appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors.
- リンク情報
- ID情報
-
- DOI : 10.1128/MCB.23.24.9025-9031.2003
- ISSN : 0270-7306
- PubMed ID : 14645515
- Web of Science ID : WOS:000187040400011