2015年12月
Multimodal sensory integration in single cerebellar granule cells in vivo
ELIFE
- ,
- ,
- 巻
- 4
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.7554/eLife.12916
- 出版者・発行元
- ELIFE SCIENCES PUBLICATIONS LTD
The mammalian cerebellum is a highly multimodal structure, receiving inputs from multiple sensory modalities and integrating them during complex sensorimotor coordination tasks. Previously, using cell-type-specific anatomical projection mapping, it was shown that multimodal pathways converge onto individual cerebellar granule cells (Huang et al., 2013). Here we directly measure synaptic currents using in vivo patch-clamp recordings and confirm that a subset of single granule cells receive convergent functional multimodal (somatosensory, auditory, and visual) inputs via separate mossy fibers. Furthermore, we show that the integration of multimodal signals by granule cells can enhance action potential output. These recordings directly demonstrate functional convergence of multimodal signals onto single granule cells.
- リンク情報
- ID情報
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- DOI : 10.7554/eLife.12916
- ISSN : 2050-084X
- PubMed ID : 26714108
- Web of Science ID : WOS:000374009500001