Shin-ichi Hirashima

Profile Information

Affiliation: School of Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Degree: 博士（薬学）(岐阜薬科大学)

J-GLOBAL ID: 201801013873196281
researchmap Member ID: B000326069

External link: https://www.ps.toyaku.ac.jp/yakukagaku/

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Research History

Apr, 2021 - Present

Tokyo University of Pharmacy and Life Sciences
Apr, 2018 - Mar, 2021

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Aug, 2013 - Mar, 2018

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Jul, 2012 - Jul, 2013

Research Institute of Science and Technology, Chubu University
Dec, 2011 - Jun, 2012

Chubu University
Apr, 2010 - Nov, 2011

博士研究員, 化学科, シカゴ大学
Apr, 2008 - Mar, 2010

特別研究員（DC2）, 日本学術振興会
Nov, 2007 - Jan, 2008

インターンシップフェロー, 化学科, ミシシッピ大学

Education

Apr, 2007 - Mar, 2010

Graduate School Department of Pharmaceutical Science, Gifu Pharmaceutical University
Apr, 2005 - Mar, 2007

Graduate School Department of Pharmaceutical Science, Gifu Pharmaceutical University
Apr, 2001 - Mar, 2005

Department of Manufacturing Pharmacy, Faculty of Pharmaceutical Science, Gifu Pharmaceutical University

Awards

Sep, 2020

奨励賞, 日本薬学会関東支部

Papers

Regioselective One-Pot Synthesis of Vicinal Bisphosphine Derivatives from Nitroalkenes by Hydrophosphinylation/Elimination/Hydrophosphinylation.

Eiki Hirota, Shin-Ichi Hirashima, Ryuki Morita, Junya Takase, Yasuyuki Matsushima, Kosuke Nakashima, Hiroshi Akutsu, Tsuyoshi Miura

Organic letters, 26(9) 1797-1802, Mar 8, 2024
Vicinal All‐Carbon Quaternary Stereocenter Construction with Trifluoromethyl Groups via Organocatalytic Asymmetric Cascade Michael/Michael Reaction

Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura

Chemistry – An Asian Journal, Jan 2, 2024
Synthesis of 2-Substituted Indoles via Migration Reaction of 3-Substituted Indoles with Triflic Acid.

Kosuke Nakashima, Yuka Kudo, Yasuyuki Matsushima, Shin-Ichi Hirashima, Tsuyoshi Miura

Chemical & pharmaceutical bulletin, 72(3) 336-339, 2024
Organocatalyzed Synthesis of Bicyclic γ‐Lactam Derivatives via Asymmetric Conjugate Addition of Cyclic β‐Keto Esters to Benzoyl Acrylonitriles

Yasuyuki Matsushima, Satsuki Kubokawa, Mia Watanabe, Kosuke Nakashima, Shin-ichi Hirashima, Tsuyoshi Miura

Asian Journal of Organic Chemistry, Dec 21, 2023
Fluorescent Rotary Switches: Four- vs Three-Substituted Phthalimide Boron Difluoride Schiff Base Complexes

Dancho Yordanov, Rastislav Smolka, Kosuke Nakashima, Shin-ichi Hirashima, Yasuyuki Matsushima, Martin Vala, Jozef Krajčovič, Martin Weiter, Tsuyoshi Miura, Anton Georgiev

The Journal of Organic Chemistry, Dec 15, 2023
Catalytic Synthesis of Phthalide Derivatives via Asymmetric Bromolactonization of Stilbene-type Carboxylic Acids using N,N-Dibenzyl Diaminomethylenemalononitrile as Organocatalyst

Yasuyuki Matsushima, Shunsuke Fukuda, Yusuke Kobayashi, Hiroyasu Nezu, Kosuke Nakashima, Shin-ichi Hirashima, Tsuyoshi Miura

ASIAN JOURNAL OF ORGANIC CHEMISTRY, May, 2023
Highly efficient, asymmetric, and organocatalyst-based Henry reactions between α,β-unsaturated trifluoromethyl ketone and nitromethane

Ryo Tsuyusaki, Kosuke Nakashima, Miki Shimomura, Masahiro Kawada, Yasuyuki Matsushima, Shin-ichi Hirashima, Tsuyoshi Miura

Tetrahedron Letters, 117 154375-154375, Mar, 2023 Peer-reviewed
Asymmetric Direct Vinylogous Conjugate Addition of α,β‐Unsaturated γ‐Butyrolactam to Acyl Acrylonitriles using Organocatalysts

Daiki Ishii, Shin-ichi Hirashima, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Hiroshi Akutsu, Tsuyoshi Miura

Asian Journal of Organic Chemistry, Feb 27, 2023
Synthesis of Chiral α‐Substituted β‐Aminophosphine Derivatives through Asymmetric Hydrophosphinylation Utilizing Secondary Phosphine Sulfides

Shin‐ichi Hirashima, Eiki Hirota, Yasuyuki Matsushima, Naoki Noda, Yuya Nishimura, Takefumi Narushima, Kosuke Nakashima, Tsuyoshi Miura

Chemistry – An Asian Journal, 17(24), Nov 11, 2022 Peer-reviewed
Asymmetric Friedel–Crafts alkylation of indoles with α,β‐unsaturated trifluoromethyl ketones using a squaramide organocatalyst

Kosuke Nakashima, Sumire Hanamura, Aoi Imamura, Yasuyuki Matsushima, Shin-ichi Hirashima, Tsuyoshi Miura

Asian Journal of Organic Chemistry, Aug 19, 2022
Solvent-Triggered Long-Range Proton Transport in 7-Hydroxyquinoline Using a Sulfonamide Transporter Group

Kosuke Nakashima, Anton Georgiev, Dancho Yordanov, Yasuyuki Matsushima, Shin-ichi Hirashima, Tsuyoshi Miura, Liudmil Antonov

The Journal of Organic Chemistry, 87(10) 6794-6806, May 5, 2022
Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to ( E )‐ and ( Z) ‐Benzoyl Acrylonitriles Using Organocatalysts

Daiki Ishii, Shin‐ichi Hirashima, Hiroshi Akutsu, Kosuke Nakashima, Yasuyuki Matsushima, Takaaki Sakai, Tsuyoshi Miura

Asian Journal of Organic Chemistry, 11(5), May, 2022 Peer-reviewed
Asymmetric conjugate addition–cyclization of cyclohexane-1,2-dione with alkylidenemalononitriles using diaminomethylenemalononitrile organocatalyst

Yasuyuki Matsushima, Yuta Iino, Yuka Tsuruta, Kosuke Nakashima, Shin-ichi Hirashima, Tsuyoshi Miura

Tetrahedron Letters, 153773-153773, Mar, 2022
Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol

Kosuke Nakashima, Asako Minai, Yuichi Okuaki, Yasuyuki Matsushima, Shin-ichi Hirashima, Tsuyoshi Miura

Tetrahedron Letters, 153733-153733, Mar, 2022
Asymmetric Henry Reaction of Trifluoromethyl Enones with Nitromethane Using a N,N ‐Dibenzyl Diaminomethylenemalononitrile Organocatalyst

Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Misaki Yamada, Akihiro Kozakai, Yasuyuki Matsushima, Shin-ichi Hirashima, Tsuyoshi Miura

Chemistry – An Asian Journal, 17(4), Feb 14, 2022
Development of Green Asymmetric Organocatalytic Synthesis

Shin-ichi Hirashima

YAKUGAKU ZASSHI, 141(10) 1137-1145, Oct 1, 2021
Diaminomethylenemalononitrile as a Chiral Single Hydrogen Bond Catalyst: Application to Enantioselective Conjugate Addition of α‐Branched Aldehydes

Masahiro Kawada, Ryo Tsuyusaki, Kosuke Nakashima, Hiroshi Akutsu, Shin-ichi Hirashima, Takashi Matsumoto, Hikaru Yanai, Tsuyoshi Miura

Chemistry – An Asian Journal, 16(16) 2272-2275, Aug 16, 2021 Peer-reviewed
Acylhydrazone Subunits as a Proton Cargo Delivery System in 7‐Hydroxyquinoline

Kosuke Nakashima, Anton Petek, Yutaro Hori, Anton Georgiev, Shin-ichi Hirashima, Yasuyuki Matsushima, Dancho Yordanov, Tsuyoshi Miura, Liudmil Antonov

Chemistry – A European Journal, 27(45) 11559-11566, Aug 11, 2021 Peer-reviewed
Alpha-dystroglycan binding peptide A2G80-modified stealth liposomes as a muscle-targeting carrier for Duchenne muscular dystrophy

Sasaki, E., Hayashi, Y., Kimura, Y., Sashida, S., Hamano, N., Nirasawa, K., Hamada, K., Katagiri, F., Kikkawa, Y., Sakai, T. …

Journal of Controlled Release, 329 1037-1045, 2021 Peer-reviewed
Asymmetric direct vinylogous conjugate addition of substituted furanone derivatives to benzoyl acrylonitrile: Stereoselective synthesis toward bicyclic γ-lactams

Ishii, D., Hirashima, S.-I., Nakashima, K., Akutsu, H., Sakai, T., Matsushima, Y., Kawada, M., Miura, T.

Organic Letters, 23(2) 480-485, 2021 Peer-reviewed

Misc.

筋組織へのターゲティング能を有する全身投与型ナノDDSの開発

佐々木愛理, 林由浩, 木村優花, 韮沢慧, 濱野展人, 片桐文彦, 坂井崇亮, 吉田彰宏, 平島真一, 三浦剛 …

日本筋学会学術集会プログラム・抄録集, 5回 100-100, Aug, 2019
A2G80ペプチド修飾リポソームの全身投与による筋組織移行性評価

林由浩, 佐々木愛理, 木村優花, 韮沢慧, 濱野展人, 片桐文彦, 坂井崇亮, 吉田彰宏, 平島真一, 三浦剛 …

日本薬剤学会年会講演要旨集, 34年会 182-182, May, 2019
A2G80ペプチド修飾リポソームの全身投与による筋組織移行性の評価

林由浩, 佐々木愛理, 木村優花, 韮沢慧, 濱野展人, 片桐文彦, 坂井崇亮, 吉田彰宏, 平島真一, 三浦剛 …

日本薬学会年会要旨集, 139年会(4) 87-87, Mar, 2019

Research Projects

求核部位選択性を鍵とする多彩なリンカルコゲニド類の合成展開

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

平島真一
Synthesis of chiral phosphorous compounds utilizing sulfur

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Hirashima Shin-ichi
Development of novel push-pull ethylene organocatalysts and their application to synthesis of medicines

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Miura Tsuyoshi

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Research Areas

Research History

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Papers

Misc.

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