論文

国際誌
2022年2月

Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • Tetsuya Suzuki
  • Yusuke Asai
  • Satoshi Ide
  • Saori Fukuda
  • Akihito Tanaka
  • Yumiko Shimanishi
  • Kozue Takahashi
  • Mari Terada
  • Lubna Sato
  • Mitsuhiro Sato
  • Makoto Inada
  • Gen Yamada
  • Yusuke Miyazato
  • Yutaro Akiyama
  • Hidetoshi Nomoto
  • Takato Nakamoto
  • Keiji Nakamura
  • Tomiteru Togano
  • Shinichiro Morioka
  • Noriko Kinoshita-Iwamoto
  • Sho Saito
  • Satoshi Kutsuna
  • Norio Ohmagari
  • 全て表示

28
2
開始ページ
206
終了ページ
210
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jiac.2021.10.012
出版者・発行元
ELSEVIER

INTRODUCTION: The ability to predict which patients with a history of coronavirus disease (COVID-19) will exhibit a high antibody titer is necessary for more efficient screening of potential convalescent plasma donors. We aimed to identify factors associated with a high immunoglobulin G (IgG) titer in Japanese convalescent plasma donors after COVID-19. METHODS: This cross-sectional study included volunteers undergoing screening for convalescent plasma donation after COVID-19. Serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-protein IgG antibodies were measured using a high-sensitivity chemiluminescence enzyme immunoassay. RESULTS: IgG antibodies were measured in 581 patients, 534 of whom had full information of selected independent variables. Multiple linear regression analysis revealed that increasing age (1.037 [1,025, 1.048]), days from symptom onset to sampling (0.997 [0.995, 0.998]), fever (1.664 [1.226, 2.259]), systemic corticosteroid use during SARS-CoV-2 infection (2.382 [1.576, 3.601]), and blood type AB (1.478 [1.032, 2.117]) predict antibody titer. CONCLUSION: Older participants, those who experienced fever during infection, those treated with systemic corticosteroids during infection, those from whom samples were obtained earlier after symptom onset, and those with blood type AB are the best candidates for convalescent plasma donation. Therefore, these factors should be incorporated into the screening criteria for convalescent plasma donation after SARS-CoV-2 infection.

リンク情報
DOI
https://doi.org/10.1016/j.jiac.2021.10.012
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34756573
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526427
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000744093000012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jiac.2021.10.012
  • ISSN : 1341-321X
  • eISSN : 1437-7780
  • PubMed ID : 34756573
  • PubMed Central 記事ID : PMC8526427
  • Web of Science ID : WOS:000744093000012

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