Shinji Hadano

J-GLOBAL         Last updated: Jan 14, 2019 at 14:26
Shinji Hadano
Tokai University
School of Medicine
Job title
Ph.D.(Tsukuba University)

Research Areas


Academic & Professional Experience

Apr 2011
Professor, School of Medicine, Tokai University
Apr 2005
Mar 2011
Associate Professor, School of Medicine, Tokai University
Apr 2004
Mar 2005
Associate Professor, The Institute of Medical Sciences, Tokai University
Apr 2000
Mar 2004
Assistant Professor, The Institute of Medical Sciences, Tokai University
Apr 1999
Mar 2000
Instructor, The Institute of Medical Sciences, Tokai University
Sep 1996
Mar 1999
Visiting Scientist, Centre for Molecular Medicine and Therapeutics, University of British Columbia
Apr 1996
Mar 1999
Researcher, ICORP, JST
Oct 1994
Mar 1996
Instructor, The Institute of Medical Sciences, Tokai University
Apr 1994
Sep 1994
Researcher/Group Leader, JST/ Ikeda GenoSPHERE project
Apr 1992
Mar 1994
Researcher/Group Leader, JST/ Ikeda GenoSPHERE project

Awards & Honors

Matsumae Shigeyoshi Memorial Scientific Award
Nature Genetics Poster Prize HGM 2000, Second Place Award

Published Papers

Sato K, Otomo A, Ueda MT, Hiratsuka Y, Suzuki-Utsunomiya K, Sugiyama J, Murakoshi S, Mitsui S, Ono S, Nakagawa S, Shang HF, Hadano S
The Journal of biological chemistry   293(44) 17135-17153   Nov 2018   [Refereed]
Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H
Nature medicine   24(10) 1579-1589   Aug 2018   [Refereed]
Mitsui S, Otomo A, Nozaki M, Ono S, Sato K, Shirakawa R, Adachi H, Aoki M, Sobue G, Shang HF, Hadano S
Molecular brain   11(1) 30   May 2018   [Refereed]
Imaizumi K, Fujimori K, Ishii S, Otomo A, Hosoi Y, Miyajima H, Warita H, Aoki M, Hadano S, Akamatsu W, Okano H
eNeuro   5(2) e0368-17.2018   Mar 2018   [Refereed]
Zhou Q, Chen Y, Wei Q, Cao B, Wu Y, Zhao B, Ou R, Yang J, Chen X, Hadano S, Shang HF
Molecular neurobiology   54(5) 3189-3194   Jul 2017   [Refereed]
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
Moriya Y, Nagata E, Fujii N, Satoh T, Ogawa H, Hadano S, Takizawa S
The Tokai journal of experimental and clinical medicine   42(1) 13-18   Apr 2017   [Refereed]
Development of the practical studies for learning and understanding genes in the upper secondary school in collaboration with the university.
Inoue, Y., Otomo, A., Takahashi, K., Moriya, H., Ohnuki, Y., Taniguchi, Y., Izumi, S., and Hadano, S.
Jpn. J. Biol. Educ.   58(3) 98-113   2017   [Refereed]
Kanno T, Yasutake K, Tanaka K, Hadano S, Ikeda JE
PloS one   12(10) e0186227   2017   [Refereed]
Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang HF, Yoshii F
Human molecular genetics   25(15) 3321-3340   Aug 2016   [Refereed]
S. Yokoyama, J. Wada, T. Kushida, R. Araki, T. Ishida, A. Otomo, A. Otomo, S. Hadano, H. Kimura, H. Kimura
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016   303-304   Jan 2016
This paper describes a novel device with high-throughput for evaluating an axonal transport and dynamics of acidic vesicles including autophagosomes in living neurons. A high-efficient and highthroughput device for axonal transport quantification ...
Chen Y, Wei Q, Chen X, Li C, Cao B, Ou R, Hadano S, Shang HF
Frontiers in molecular neuroscience   9 69   2016   [Refereed]
Yang Y, Tang L, Zhang N, Pan L, Hadano S, Fan D
Amyotrophic lateral sclerosis & frontotemporal degeneration   16(5-6) 378-384   Feb 2015   [Refereed]
Chen Y, Zheng ZZ, Chen X, Huang R, Yang Y, Yuan L, Pan L, Hadano S, Shang HF
Neurobiology of aging   35(3) 7-726   Mar 2014   [Refereed]
Kanno T, Tanaka K, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, Hirayama N, Ikeda JE
Free radical biology & medicine   53(11) 2028-2042   Dec 2012   [Refereed]
Pan L, Yoshii Y, Otomo A, Ogawa H, Iwasaki Y, Shang HF, Hadano S
PloS one   7(3) e33409   2012   [Refereed]
Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, Ikeda JE
Experimental neurology   232(1) 41-52   Nov 2011   [Refereed]
Yoshii Y, Otomo A, Pan L, Ohtsuka M, Hadano S
Neuroscience research   70(3) 321-329   Jul 2011   [Refereed]
Otomo A, Kunita R, Suzuki-Utsunomiya K, Ikeda JE, Hadano S
FEBS letters   585(5) 730-736   Mar 2011   [Refereed]
Hadano S, Yoshii Y, Otomo A, Kunita R, Suzuki-Utsunomiya K, Pan L, Kakuta S, Iwasaki Y, Iwakura Y, Ikeda JE
Neuroscience research   68(2) 131-136   Oct 2010   [Refereed]
Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, Ikeda JE
PloS one   5(3) e9805   Mar 2010   [Refereed]
Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, Ikeda JE
Experimental neurology   211(2) 378-386   Jun 2008   [Refereed]
Otomo A, Kunita R, Suzuki-Utsunomiya K, Mizumura H, Onoe K, Osuga H, Hadano S, Ikeda JE
Biochemical and biophysical research communications   370(1) 87-92   May 2008   [Refereed]
Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
The Journal of biological chemistry   282(22) 16599-16611   Jun 2007   [Refereed]
Suzuki-Utsunomiya K, Hadano S, Otomo A, Kunita R, Mizumura H, Osuga H, Ikeda JE
Biochemical and biophysical research communications   354(2) 491-497   Mar 2007   [Refereed]
Hadano S, Benn SC, Kakuta S, Otomo A, Sudo K, Kunita R, Suzuki-Utsunomiya K, Mizumura H, Shefner JM, Cox GA, Iwakura Y, Brown RH Jr, Ikeda JE
Human molecular genetics   15(2) 233-250   Jan 2006   [Refereed]
Okada Y, Sakai H, Kohiki E, Suga E, Yanagisawa Y, Tanaka K, Hadano S, Osuga H, Ikeda JE
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   25(7) 794-806   Jul 2005   [Refereed]
Hadano S, Otomo A, Suzuki-Utsunomiya K, Kunita R, Yanagisawa Y, Showguchi-Miyata J, Mizumura H, Ikeda JE
FEBS letters   575(1/3) 64-70   Sep 2004   [Refereed]
Kunita R, Otomo A, Mizumura H, Suzuki K, Showguchi-Miyata J, Yanagisawa Y, Hadano S, Ikeda JE
The Journal of biological chemistry   279(37) 38626-38635   Sep 2004   [Refereed]
Otomo A, Hadano S, Okada T, Mizumura H, Kunita R, Nishijima H, Showguchi-Miyata J, Yanagisawa Y, Kohiki E, Suga E, Yasuda M, Osuga H, Nishimoto T, Narumiya S, Ikeda JE
Human molecular genetics   12(14) 1671-1687   Jul 2003   [Refereed]
Nagano I, Murakami T, Shiote M, Manabe Y, Hadano S, Yanagisawa Y, Ikeda JE, Abe K
Neurological research   25(5) 505-509   Jul 2003   [Refereed]
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR
Human molecular genetics   11(23) 2815-2828   Nov 2002   [Refereed]
Okada T, Gondo Y, Goto J, Kanazawa I, Hadano S, Ikeda JE
Human genetics   110(4) 302-313   Apr 2002   [Refereed]
Xu M, Okada T, Sakai H, Miyamoto N, Yanagisawa Y, MacKenzie AE, Hadano S, Ikeda JE
Biochimica et biophysica acta   1574(1) 35-50   Feb 2002   [Refereed]
S. Hadano, C. K. Hand, H. Osuga, Y. Yanagisawa, A. Otomo, R. S. Devon, N. Miyamoto, J. Showguchi-Miyata, Y. Okada, R. Singaraja, D. A. Figlewicz, T. Kwiatkowski, B. A. Hosler, T. Sagie, J. Skaug, J. Nasir, Jr Brown, S. W. Scherer, G. A. Rouleau, M. R. Hayden, J. E. Ikeda
Nature Genetics   29 352   Dec 2001
Shinji Hadano, Shinji Hadano, Collette K. Hand, Hitoshi Osuga, Hitoshi Osuga, Yoshiko Yanagisawa, Asako Otomo, Rebecca S. Devon, Natsuki Miyamoto, Junko Showguchi-Miyata, Yoshinori Okada, Roshni Singaraja, Denise A. Figlewicz, Thomas Kwiatkowski, Betsy A. Hosler, Tally Sagie, Jennifer Skaug, Jamal Nasir, Jamal Nasir, Robert H. Brown, Stephen W. Scherer, Guy A. Rouleau, Michael R. Hayden, Joh E. Ikeda, Joh E. Ikeda, Joh E. Ikeda
Nature Genetics   29 166-173   Oct 2001
Amyotrophic lateral sclerosis 2 (ALS2) is an autosomal recessive form of juvenile ALS and has been mapped to human chromosome 2q33. Here we report the identification of two independent deletion mutations linked to ALS2 in the coding exons of the n...
Shinji Hadano, Shinji Hadano, Yoshiko Yanagisawa, Jennifer Skaug, Keith Fichter, Jamal Nasir, Duane Martindale, Ben F. Koop, Stephen W. Scherer, Donald W. Nicholson, Guy A. Rouleau, Joh E. Ikeda, Joh E. Ikeda, Michael R. Hayden
Genomics   71 200-213   Jan 2001
Amyotrophic lateral sclerosis is a progressive neuro-degenerative disease that manifests as selective upper and lower motor neuron degeneration. The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2) has previously been mapp...
Noriko Matsuyama, Shinji Hadano, Shinji Hadano, Kyuichiro Onoe, Kyuichiro Onoe, Hitoshi Osuga, Hitoshi Osuga, Junko Showguchi-Miyata, Yoichi Gondo, Yoichi Gondo, Joh E. Ikeda, Joh E. Ikeda, Joh E. Ikeda
Genomics   69 72-85   Oct 2000
Huntington's disease (HD) is associated with a significant expansion of a CAG trinucleotide repeat, which results in a lengthened polyglutamine tract in the single gene product, huntingtin, on human 4p16.3. We isolated cDNA clones that encompassed...
Yasushi Saitoh, Natsuki Miyamoto, Takeya Okada, Yoichi Gondo, Junko Showguchi-Miyata, Shinji Hadano, Joh E. Ikeda, Joh E. Ikeda
Genomics   67 291-300   Aug 2000
We have recently identified a tandem repetitive DNA sequence that we designated the RS447 megasatellite. In this study, we describe a functional novel deubiquitinating enzyme (USP17, 60 kDa) gene that is intronless and encoded by the RS447 repeati...
Kenji Yamamoto, Kenji Yamamoto, Harumi Sakai, Shinji Hadano, Yoichi Gondo, Yoichi Gondo, Joh E. Ikeda, Joh E. Ikeda
Biochemical and Biophysical Research Communications   264 998-1006   Nov 1999
The spinal muscular atrophies (SMA), characterized by motor neuron loss and progressive paralysis, are among the most common autosomal recessive disorders. Recently, two SMA candidate genes, NAIP (neuronal apoptosis inhibitory protein) and surviva...
S. Hadano, J. Nasir, K. Nichol, D. M. Rasper, J. P. Vaillancourt, S. W. Sherer, B. G. Beatty, J. E. Ikeda, D. W. Nicholson, M. R. Hayden
Mammalian Genome   10 757-760   Aug 1999
Shinji Hadano, Shinji Hadano, Kerrie Nichol, Ryan R. Brinkman, Jamal Nasir, Duane Martindale, Ben F. Koop, Donald W. Nicholson, Stephen W. Scherer, Joh E. Ikeda, Joh E. Ikeda, Michael R. Hayden
Genomics   55 106-112   Jan 1999
The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosom...
Shinji Hadano, Shinji Hadano, Yoshikazu Ishida, Joh E. Ikeda, Joh E. Ikeda
DNA Research   5 177-186   Jan 1998
Five distinct novel transcripts (RES4-22, -23, -24, -25 and -26) that mapped to the 1-Mb interval between D4S180 and D4S183 on human chromosome 4p16.3 close to the Huntington's disease (HD) gene were isolated, and the structure and exon/intron org...
Dita M. Rasper, John P. Vaillancourt, Shinji Hadano, Shinji Hadano, Vicky M. Houtzager, Isolde Seiden, Sabina L.C. Keen, Paul Tawa, Steve Xanthoudakis, Jamal Nasir, Duane Martindale, Ben F. Koop, Erin P. Peterson, Nancy A. Thornberry, Jing Qi Huang, David P. MacPherson, Shawn C. Black, Felicita Hornung, Michael J. Lenardo, Michael R. Hayden, Sophie Roy, Donald W. Nicholson, Donald W. Nicholson
Cell Death and Differentiation   5 271-288   Jan 1998
Apoptotic cell suicide initiated by ligation of CD95 (Fas/APO-1) occurs through recruitment, oligomerization and autocatalytic activation of the cysteine protease, caspase-8 (MACH, FLICE, Mch5). An endogenous mammalian regulator of this process, n...
Yoichi Gondo, Takeva Okada, Shinji Hadano, Jun Goto, Ichiro Kanazawa, Joh E. Ikepa
Japanese Journal of Human Genetics   42 41   Dec 1997
While positional-cloning of the Huntington's disease (HD) gene at the Human 4p region, a novel tandem repetitive sequence RS447, a unit size of which was 4746 bp was identified (Kogi et al., in preparation). Pulsedfield gel electrophoresis reveale...
Mieko Kogi, Mieko Kogi, Shinichi Fukushige, Christophe Lefevre, Christophe Lefevre, Shinji Hadano, Joh E. Ikeda, Joh E. Ikeda
Genomics   42 278-283   Jun 1997
In an effort to analyze the genomic region of the distal half of human chromosome 4p, to where Huntington disease and other diseases have been mapped, we have isolated the cosmid clone (CRS447) that was likely to contain a region with specific rep...
Shinji Hadano, Shinji Hadano, Yoshikazu Ishida, Hitoshi Tomiyasu, Kenji Yamamoto, Gillian P. Bates, Joh E. Ikeda, Joh E. Ikeda
DNA Research   3 239-255   Jan 1996
Six hundred and twenty-seven cDNA clones from human brain cDNA libraries were characterized and integrated into a transcript map of the 1-Mb region on human chromosome 4p16.3 containing the Huntington's disease (HD) gene. Six hundred and seventy-t...
Haruhiko Yokoi, Shinji Hadano, Mieko Kogi, Xiaolin Kang, Kyo Wakasa, Joh E. Ikeda, Joh E. Ikeda, Joh E. Ikeda
Genomics   20 404-411   Jan 1994
The genes that cause a variety of neurologic and neuromuscular disorders have been mapped to the distal region of Xq. In an effort to isolate genes from this area, a regional genomic library of the distal 30% of Xq was constructed from a single me...
Yoshikazu Ishida, Shinji Hadano, Tomiko Nagayama, Tomiko Nagayama, Hitoshi Tomiyasu, Hitoshi Tomiyasu, Kyo Wakasa, Joh E. Ikeda, Joh E. Ikeda
Genomics   22 302-312   Jan 1994
We have established an approach to the isolation of ex pressed DNA sequences from a defined region of the human chromosome. The method relies on the direct screening of cDNA libraries using pooled single- copy microclones generated by a laser chro...
Shinji Hadano, Yoshikazu Ishida, Gillian P. Bates, Tomiko Nagayama, Ichiro Kanazawa, Hans Lehrach, Joh e. Ikeda
Genetic Analysis: Biomolecular Engineering   10 105-108   Jan 1993
We have developed a method for the whole sequence amplification of yeast artificial chromosome (YAC) DNA excised from preparative pulsed-field gel electrophoresis using single unique primer-polymerase chain reaction procedures. We used seven conti...
Shinji Hadano, Shinji Hadano, Masahiko Watanabe, Masahiko Watanabe, Haruhiko Yokoi, Mieko Kogi, Ikuko Kondo, Hiroshi Tsuchiya, Ichiro Kanazawa, Kyo Wakasa, Joh E. Ikeda, Joh E. Ikeda, Joh E. Ikeda
Genomics   11 364-373   Jan 1991
We have developed an argon laser chromosome microdissection technique in conjunction with a polymerase chain reaction (PCR) approach to directly amplify microdissected chromosomes. The single 22-mer primer used in PCR, although unique in sequence ...
M. Ogasawara, T. Seino, S. Hadano, A. Ito, H. Goto, M. Itakura
Advances in experimental medicine and biology   253 A 369-374   Dec 1989
S. Hadano, K. Yoshizawa, T. Ookubo, S. Nissato, I. Kanazawa
Japanese Journal of Neuropsychopharmacology   11 525-534   Jan 1989
Ogasawara, M., Hadano, S., Kasugai, A., Ito, A., and Ikawa, S.
Jpn. J. Phys. Fitness Sports Med.   37(1) 85-92   Feb 1988   [Refereed]
Shinji Hadano, Satoshi Sakai, Masashi Ogasawara, Akira Ito
Japanese Journal of Physical Fitness and Sports Medicine   37 225-233   Jan 1988
In order to elucidate effects of the exercise intensity on purine catabolism, we performed exhausitve exercise (Exh-ex), 80% VO2max exercise (80%-ex) and 70%VO2max exercise (70%-ex) test by a bicycle ergometer, and estimated the purine catabolism ...
Hadano, S., Ogasawara, M., and Ito, A.
J. Physiol. Soc. Jap.   49(5) p151-159   May 1987
S. Hadano, T. Mikami, A. Ito, T. Fujishima
Rinsho byori. The Japanese journal of clinical pathology   34 1070-1074   Sep 1986
Exercise-induced hyperuricemia (4) -uric acid metabolism in athletes.
Shinji Hadano
Uric Acid Res. (Nyosan Kenkyu)   10(2) 65-74   1986   [Refereed]


Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, 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Autophagy   12(1) 1-222   2016   [Refereed]
Shinji Hadano
Journal of Japanese Cosmetic Science Society   38(4) 250-257   2014   [Invited]
Otomo A, Pan L, Hadano S
Neurology research international   2012 498428   2012   [Refereed]
ALS2-linked motor neuron diseases
Shinji Hadano
Clinical Neuroscience   26(3) 323-324   2008   [Invited]
Hadano S, Kunita R, Otomo A, Suzuki-Utsunomiya K, Ikeda JE
Neurochemistry international   51(2-4) 74-84   Jul 2007   [Refereed]
Hadano S, Ikeda JE
Methods in enzymology   403 310-321   2005   [Refereed]
Hadano S
Seikagaku. The Journal of Japanese Biochemical Society   74(6) 483-489   Jun 2002   [Refereed]
Advances in understanding of the molecular pathogenesis for amyotrophic lateral sclerosis (ALS).
Shinji Hadano
Exp. Med. (Jikken Igaku)   19(17) 2283-2288   2001   [Invited]
Advances in understanding the molecular pathogenesis of Huntington's disease.
Hadano, S. and Ikeda, J. -E
Neurol. Med.   54(2) 114-121   2001   [Invited]
Dynamic mutation and neuromuscular-degenerative diseases.
Hadano, S. and Ikeda, J. -E
Saishin Igaku   52(10) 2170-2176   1997   [Invited]
A laser-based chromosome microdissection
Hadano, S. and Ikeda, J. -E
Soshiki Baiyou   22(2) 55-59   1996   [Invited]
Gene Therapy
Hadano, S. and Ikeda, J. -E.
J. Adult Diseases   25(1) 26-31   1995   [Invited]
Positional cloning
Shinji Hadano
Inflammation and Immunology   25(1) 26-31   1995   [Invited]
S. Hadano, J. E. Ikeda
Nippon rinsho. Japanese journal of clinical medicine   51(9) 2240-2245   Sep 1993   [Invited]
We have developed an argon ion laser chromosome microdissection technique in conjunction with a single unique primer polymerase chain reaction (SUP-PCR) to directly amplify microdissected chromosomes. The 22-mer primer used in PCR, although unique...
Recent advances in the measurement of fatigue
Ito, A., and Hadano, S.
Rinsho Kensa   29(10) 1153-1159   1985   [Invited]
Yoshii, Y., Hadano, S., Otomo, A., Suzuki, K., Ikeda, K., Ikeda, J. -E., and Iwasaki, Y.
Neurology   73(8) 648-649   [Refereed]
Yoshii, Y., Hadano, S., Otomo, A., Kawabe, K., Ikeda, K., and Iwasaki, Y
Neurology   74(24) 2027   [Refereed]

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2009    Investigator(s): 國田 竜太, Shinji HADANO
Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of progressive neurodegenerative disorders characterized by a selective loss of motor neurons in the cerebral cortex, brainstem, and spinal cord. Currently, the mechanism for the selecti...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007    Investigator(s): Shinji HADANO
Loss of function mutations in ALS2 account for a number of juvenile/infantile recessive motor neuron diseases, indicating that its gene product, ALS2, plays a crucial role in maintenance and survival for a subset of neurons. However, the normal ph...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2004    Investigator(s): Shinji HADANO
The aim of this study was to delineate molecular function of ALS2, a causative gene product underlying a number of recessive motor neuron diseases, thereby clarifying the molecular mechanisms for neuronal cell dysfunction and death resulted from l...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(C), 特定領域研究)
Project Year: 2000 - 2004    Investigator(s): Joh-E IKEDA
Goals of our study were to elucidate the mechanism of HD pathogenesis and to develop a novel therapy for HD through the analysis for the molecular mechanisms of the transcriptional regulation for the HD gene and the characterization of miniature p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Yasushi SAITOH
The nuclear inclusion body formation of ubiquitin-huntingtin conjugate must be controlled by ubiquitin conjugating enzymes and deubiquitinating enzymes. One ubiquitin-conjugating enzyme was reported to bind huntingtin. In contrast, the function of...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Yoichi GONDO
We proposed the concept of "megasatellite DNA" and it has been widely accepted. The RS447 megasatellite DNA was firstly identified on human 4p15. The unit size of 4746bp is tandemly repeated about 20 to 100 times. The copy number is highly polymor...