論文

査読有り
2010年8月

Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells

SCIENCE SIGNALING
  • Yutaka Arimura
  • ,
  • Junji Yagi

3
137
開始ページ
rs1
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1126/scisignal.2000966
出版者・発行元
AMER ASSOC ADVANCEMENT SCIENCE

The phosphorylation and dephosphorylation of signaling molecules play a crucial role in various cellular processes, including immune responses. To date, the global expression profile of protein tyrosine phosphatases (PTPs) in various immune cells has not been described. With the RefDIC (Reference Genomics Database of Immune Cells) database compiled by RIKEN (Rikagaku Kenkyusho), we examined the expression patterns of PTP-encoding genes in mice and identified between 57 and 64 PTP-encoding genes (depending on cutoff values) that were commonly expressed in immune cells. Cells of different lineages contained additional, unique PTP-encoding genes, which resulted in a total of 58 to 76 genes. Compared with cells from nonimmune tissues, immune cells exhibited enhanced expression of the genes encoding 8 PTP-encoding genes, including Ptprc, Ptpn6, and Ptpn22, but had barely detectable expression of 11 PTP-encoding genes, including Ptprd and Tns1. Each immune cell lineage had between 2 and 18 PTP-encoding genes expressed at relatively high or low extents relative to the average expression among immune cells; for example, Ptprj in B cells, Dusp3 in macrophages, Ptpro in dendritic cells, and Ptprg in mast cells. These PTPs potentially play important roles in each cell lineage, and our analysis provides insight for future functional studies.

Web of Science ® 被引用回数 : 40

リンク情報
DOI
https://doi.org/10.1126/scisignal.2000966
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20807954
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000281481600003&DestApp=WOS_CPL

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