論文

査読有り
2010年12月

Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in D-galactosamine-sensitized mice

CLINICAL IMMUNOLOGY
  • Minh Hung Dang
  • ,
  • Hidehito Kato
  • ,
  • Hidehiro Ueshiba
  • ,
  • Miyuki Omori-Miyake
  • ,
  • Satoshi Yamagoe
  • ,
  • Kazuyoshi Ando
  • ,
  • Ken'ichi Imanishi
  • ,
  • Yutaka Arimura
  • ,
  • Ikuko Haruta
  • ,
  • Tohru Kotani
  • ,
  • Makoto Ozaki
  • ,
  • Kazuo Suzuki
  • ,
  • Takehiko Uchiyama
  • ,
  • Junji Yagi

137
3
開始ページ
311
終了ページ
321
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clim.2010.08.002
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

To elucidate whether leukocyte cell derived chemotaxin 2 (LECT2) controls the progression of staphylococcal enterotoxin A (SEA) induced toxicity, we examined the role of LECT2 in a mouse model Almost all the C57BL/6 J (B6) mice survived for 72 h after the injection of 0 1 mu g of SEA and 20 mg of D galactosamme (D GalN) However, the same treatment protocol in LECT2(-/-) mice produced a high lethality (similar to 90%), severe hepatic apoptosis, and massive hepatic and pulmonary hemorrhage, similar to the situation observed in B6 mice treated with 1 0 mu g SEA/D GalN The plasma LECT2 levels in B6 mice treated with 1 0 mu g SEA/D GalN were inversely correlated with the plasma cytokine levels and were associated with prognosis LECT2 administration increased the survival of B6 mice and down regulated TNF alpha and IL 6 These results suggest the involvement of LECT2 in the regulation of fatal SEA induced toxicity in D GalN sensitized mice (C) 2010 Elsevier Inc All rights reserved

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1016/j.clim.2010.08.002
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20805039
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000284300600002&DestApp=WOS_CPL

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