論文

査読有り
2008年

Protein tyrosine phosphatases in autoimmunity

ANNUAL REVIEW OF IMMUNOLOGY
  • Torkel Vang
  • ,
  • Ana V. Miletic
  • ,
  • Yutaka Arimura
  • ,
  • Lutz Tautz
  • ,
  • Robert C. Rickert
  • ,
  • Tomas Mustelin

26
開始ページ
29
終了ページ
55
記述言語
英語
掲載種別
論文集(書籍)内論文
DOI
10.1146/annurev.immunol.26.021607.090418
出版者・発行元
ANNUAL REVIEWS

Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase (PTPN22), which is associated with multiple autoimmune diseases, and mutations that affect the exon-intron splicing of CD45 (PTPRC). We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets.

Web of Science ® 被引用回数 : 121

リンク情報
DOI
https://doi.org/10.1146/annurev.immunol.26.021607.090418
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18303998
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000255349300002&DestApp=WOS_CPL

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