論文

査読有り
2007年3月

Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase

JOURNAL OF IMMUNOLOGY
  • Timothy J. Bauler
  • ,
  • Elizabeth D. Hughes
  • ,
  • Yutaka Arimura
  • ,
  • Tomas Mustelin
  • ,
  • Thomas L. Saunders
  • ,
  • Philip D. King

178
6
開始ページ
3680
終了ページ
3687
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
AMER ASSOC IMMUNOLOGISTS

PTPN3 (PTPH1) is a cytoskeletal protein tyrosine phosphatase that has been implicated as a negative regulator of early TCR signal transduction and T cell activation. To determine whether PTPN3 functions as a physiological negative regulator of TCR signaling in primary T cells, we generated gene-trapped and gene-targeted mouse strains that lack expression of catalytically active PTPN3. PTPN3 phosphatase-negative mice were born in expected Mendelian ratios and exhibited normal growth and development. Furthermore, numbers and ratios of T cells in primary and secondary lymphoid organs were unaffected by the PTPN3 mutations and there were no signs of spontaneous T cell activation in the mutant mice with increasing age. TCR-induced signal transduction, cytokine production, and proliferation was normal in PTPN3 phosphatase-negative mice. This was observed using both quiescent T cells and recently stimulated T cells where expression of PTPN3 is substantially up-regulated. We conclude, therefore, that the phosphatase activity of PTPN3 is dispensable for negative regulation of TCR signal transduction and T cell activation.

Web of Science ® 被引用回数 : 18

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17339465
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244942400040&DestApp=WOS_CPL

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