論文

査読有り
2006年12月

Genetic background influences T-h cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4(+) T cells

INTERNATIONAL IMMUNOLOGY
  • Junji Yagi
  • ,
  • Yutaka Arimura
  • ,
  • Hiroaki Takatori
  • ,
  • Hiroshi Nakajima
  • ,
  • Itsuo Iwamoto
  • ,
  • Takehiko Uchiyama

18
12
開始ページ
1681
終了ページ
1690
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/intimm/dxl102
出版者・発行元
OXFORD UNIV PRESS

Comparative studies using T(h)2-prone BALB/c and T(h)1-prone C57BL/6 mice were performed to clarify the influence of genetic background on T-h cell differentiation. The results showed IL-4, the production of which is induced by IL-2, to be much more abundantly produced by BALB/c naive CD4(+) T cells than by C57BL/6 naive CD4(+) T cells, thereby leading to a tendency for differentiation toward T(h)2 in BALB/c naive CD4(+) T cells. This difference in IL-4 production between the two naive CD4(+) T cells appeared to be attributable to specific intracellular signaling events. Signal transducer and activator of transcription 5 (STAT5) was preferentially activated by IL-2 in CD4(+) T cells developing in BALB/c in contrast to the corresponding cells in C57BL/6. In addition, IL-4 also induced stronger STAT5 activation in CD4(+) T cells developing in BALB/c than in those developing in C57BL/6, whereas STAT6 was equally activated in these two cells. Further results supported the involvement of STAT5 in the difference in T-h cell differentiation between BALB/c and C57BL/6 naive CD4(+) T cells. STAT5A(-/-) naive CD4(+) T cells with the BALB/c genetic background showed markedly less IL-2-induced IL-4 production than BALB/c naive CD4(+) T cells. Conversely, forced expression of the constitutively active forms of STAT5A and STAT5B in C57BL/6 naive CD4(+) T cells promoted the differentiation of T(h)2 cells. Thus, our results indicate IL-2-induced IL-4 production by naive CD4(+) T cells, in which STAT5 activation is involved and directly controlled by the genetic background, to influence T-h cell differentiation in murine strains.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1093/intimm/dxl102
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17035345
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000242716500007&DestApp=WOS_CPL

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