論文

査読有り
2004年2月

Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation

INTERNATIONAL IMMUNOLOGY
  • M Koyanagi
  • ,
  • K Imanishi
  • ,
  • Y Arimura
  • ,
  • H Kato
  • ,
  • J Yagi
  • ,
  • T Uchiyama

16
2
開始ページ
315
終了ページ
326
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/intimm/dxh027
出版者・発行元
OXFORD UNIV PRESS

To determine the levels of maturation and differentiation of murine CD4 single-positive (SP) T cells, we compared the secondary responses of staphylococcal enterotoxin A (SEA)-induced neonatal thymic, adult thymic and adult splenic CD4 SP T cell blasts prepared from whole or heat-stable antigen(low) CD4 SP T cells. Proliferative responses upon re-stimulation with SEA were strong in adult splenic CD4 SP T cell blasts, but quite weak in neonatal thymic and adult thymic CD4 SP T cell blasts. SEA-induced IL-2 production was weaker in neonatal thymic blasts than in the adult splenic CD4 SP T cell blasts. In contrast, SEA-induced IL-4 production was high in neonatal thymic CD4 SP T cell blasts, and low in adult splenic and thymic CD4 SP T cell blasts. Expression of GATA-3, that directs production of IL-4 in T cells, examined at protein and mRNA levels, was higher in neonatal thymic cells than in adult thymic and splenic cells. These results suggest that neonatal and adult thymic CD4 SP T cells in the final stage of maturation are relatively immature compared with adult splenic CD4 SP T cells. The cytokine production profile of neonatal thymic CD4 SP T cells suggests that they are inclined towards a T(h)2 response.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1093/intimm/dxh027
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14734617
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188795800014&DestApp=WOS_CPL