論文

査読有り
2002年6月

A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T-h cells and regulates their responses

INTERNATIONAL IMMUNOLOGY
  • Y Arimura
  • ,
  • H Kato
  • ,
  • U Dianzani
  • ,
  • T Okamoto
  • ,
  • S Kamekura
  • ,
  • D Buonfiglio
  • ,
  • T Miyoshi-Akiyama
  • ,
  • T Uchiyama
  • ,
  • J Yagi

14
6
開始ページ
555
終了ページ
566
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/intimm/dxf022
出版者・発行元
OXFORD UNIV PRESS

We examined the co-stimulatory activity of H4/ICOS on murine activated CD4(+) T cells and found that the cross-linking of H4/ICOS enhanced their proliferation, in addition to raising IFN-gamma, IL-4 and IL-10 production to levels comparable to those induced by CD28. However, IL-2 production was only marginally co-stimulated by H4/ICOS. This distinct pattern of lymphokine production appears to be induced by a specific intracellular signaling event. Compared with CD28, H4/ICOS dominantly elicited the Akt pathway via phosphatidylinositol 3-kinase. In addition, mitogen-activated protein kinase family kinases were activated in different ways by CD28 and H4/ICOS. The strong phosphorylation of p46 c-Jun N-terminal kinase was observed upon CD28 co-stimulation, but was less potently induced by H4/ICOS. The strain diversity in the induction of H4/ICOS was recognized. The expression of H4/ICOS on BALB/c activated CD4(+) T cells was >6-fold higher compared with C57BL/6 activated CD4(+) T cells. Furthermore, BALB/c activated CD4(+) T cells exhibited more T(h)2-deviated lymphokine production as compared with C57BL/6 activated CD4(+) T cells and signaling through H4/ICOS during the primary stimulation of naive CD4(+) T cells promoted the generation of T(h)2 cells. Thus, the difference in H4/ICOS expression on activated CD4(+) T cells, which is regulated among the mouse strains, may also regulate the polarization of T-h cells.

Web of Science ® 被引用回数 : 47

リンク情報
DOI
https://doi.org/10.1093/intimm/dxf022
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12039907
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175912100003&DestApp=WOS_CPL