論文

査読有り
2001年2月

Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45

FEBS LETTERS
  • M Ogimoto
  • ,
  • Y Arimura
  • ,
  • T Katagiri
  • ,
  • K Mitomo
  • ,
  • Woodgett, JR
  • ,
  • AR Nebreda
  • ,
  • K Mizuno
  • ,
  • H Yakura

490
1-2
開始ページ
97
終了ページ
101
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0014-5793(00)02416-9
出版者・発行元
ELSEVIER SCIENCE BV

In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members, We found that CD45 negatively regulated BCR-induced c-Jun NH2-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1016/S0014-5793(00)02416-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11172819
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000167007900020&DestApp=WOS_CPL