Kan Shin

Profile Information

Affiliation: Jikei University

Degree: 博士(生命科学)(山口大学)

Researcher number: 90706186
J-GLOBAL ID: 201801001307960111
researchmap Member ID: B000318331

Research Interests

Research Areas

Awards

Papers

The stimulatory effect of fusobacteria on dendritic cells under aerobic or anaerobic conditions.

Shigeo Koido, Sankichi Horiuchi, Shin Kan, Tsuuse Bito, Zensho Ito, Kan Uchiyama, Masayuki Saruta, Nobuhiro Sato, Toshifumi Ohkusa

Scientific reports, 12(1) 10698-10698, Jun 23, 2022
Intestinal Bacteria and Dendritic Cells

KOIDO Shigeo, ITO Zensho, Kan Shin, BITO Tsuuse, HORIUCHI Sankichi, UCHIYAMA Kan, OHKUSA Toshifumi

Journal of Intestinal Microbiology, 36(3) 135-141, 2022
Growth of various obligate and facultative anaerobic intestinal bacteria in cell culture medium under aerobic and anaerobic culture conditions

Toshifumi OHKUSA, Shigeo KOIDO, Sankichi HORIUCHI, Shin KAN, Zensho ITO, Yuriko NISHIKAWA, Nobuhiro SATO

Bioscience of Microbiota, Food and Health, 41(3) 145-148, 2022
Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma.

Sachie Kiryu, Zensho Ito, Machi Suka, Tsuuse Bito, Shin Kan, Kan Uchiyama, Masayuki Saruta, Taigo Hata, Yuki Takano, Shuichi Fujioka …

BMC cancer, 21(1) 1197-1197, Nov 10, 2021
Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells

Shin Kan, Tsuuse Bito, Masamori Shimabuku, Junichi Taguchi, Toshifumi� Ohkusa, Shigetaka Shimodaira, Haruo Sugiyama, Shigeo Koido

International Journal of Oncology, Aug 14, 2020
Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1.

Zensho Ito, Shin Kan, Tsuuse Bito, Sankichi Horiuchi, Takafumi Akasu, Sayumi Yoshida, Mikio Kajihara, Atsushi Hokari, Masayuki Saruta, Noriyuki Yoshida …

Oncology, 97(3) 135-148, 2019 Peer-reviewed
Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer.

Sayumi Yoshida, Zensho Ito, Machi Suka, Tsuuse Bito, Shin Kan, Takafumi Akasu, Masayuki Saruta, Masato Okamoto, Hiroaki Kitamura, Shuichi Fujioka …

Cancer investigation, 37(9) 463-477, 2019 Peer-reviewed
Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells

Yoshitaka Sunami, Marito Araki, Shin Kan, Akihiro Ito, Yumi Hironaka, Misa Imai, Soji Morishita, Akimichi Ohsaka, Norio Komatsu

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(7) 2815-2829, Feb, 2017 Peer-reviewed
Calreticulin変異体は骨髄増殖性腫瘍におけるトロンボポエチン受容体を活性化する(Mutant calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms)

Araki Marito, Yang Yinjie, Masubuchi Nami, Hironaka Yumi, Takei Hiraku, Morishita Soji, Mizukami Yoshihisa, Kan Shin, Shirane Shuichi, Edahiro Yoko …

臨床血液, 57(9) 1517-1517, Sep, 2016
骨髄増殖性新生物(MPN)を誘発する変異calreticulinの細胞表面局在(Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms(MPNs))

Masubuchi Nami, Araki Marito, Yang Yinjie, Hironaka Yumi, Takei Hiraku, Morishita Soji, Mizukami Yoshihisa, Kan Shin, Ohsaka Akimichi, Komatsu Norio

臨床血液, 57(9) 1604-1604, Sep, 2016
Gemcitabine enhances rituximab-mediated complement-dependent cytotoxicity to B cell lymphoma by CD20 upregulation

Kazumi Hayashi, Eijiro Nagasaki, Shin Kan, Masaki Ito, Yuko Kamata, Sadamu Homma, Keisuke Aiba

Cancer Science, 107(5) 682-689, May 1, 2016 Peer-reviewed
Gemcitabine enhances rituximab-mediated complement-dependent cytotoxicity to B cell lymphoma by CD20 upregulation

Kazumi Hayashi, Eijiro Nagasaki, Shin Kan, Masaki Ito, Yuko Kamata, Sadamu Homma, Keisuke Aiba

CANCER SCIENCE, 107(5) 682-689, May, 2016 Peer-reviewed
Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Marito Araki, Yinjie Yang, Nami Masubuchi, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihisa Mizukami, Shin Kan, Shuichi Shirane, Yoko Edahiro …

BLOOD, 127(10) 1307-1316, Mar, 2016 Peer-reviewed
Expression of immune checkpoint molecules of T cell immunoglobulin and mucin protein 3/galectin-9 for NK cell suppression in human gastrointestinal stromal tumors

Hideo Komita, Shigeo Koido, Kazumi Hayashi, Shin Kan, Masaki Ito, Yuko Kamata, Masafumi Suzuki, Sadamu Homma

ONCOLOGY REPORTS, 34(4) 2099-2105, Oct, 2015 Peer-reviewed
Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells

Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Eijiro Nagasaki, Sadamu Homma

BMC CANCER, 15 726, Oct, 2015 Peer-reviewed
Gemcitabine treatment enhances HER2 expression in low HER2-expressing breast cancer cells and enhances the antitumor effects of trastuzumab emtansine

Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Takefumi Ishidao, Eijiro Nagasaki, Sadamu Homma

ONCOLOGY REPORTS, 34(1) 504-510, Jul, 2015 Peer-reviewed
Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells (vol 45, pg 470, 2014)

Shigeo Koido, Sadamu Homma, Shin Kan, Kazuki Takakura, Yoshihisa Namiki, Hiroko Kobayashi, Zensho Ito, Kan Uchiyama, Mikio Kajihara, Seiji Arihiro …

INTERNATIONAL JOURNAL OF ONCOLOGY, 46(6) 2679-2679, Jun, 2015 Peer-reviewed
Prognostic Markers for Patient Outcome Following Vaccination with Multiple MHC Class I/II-restricted WT1 Peptide-pulsed Dendritic Cells Plus Chemotherapy for Pancreatic Cancer

Kazuki Takakura, Shigeo Koido, Shin Kan, Kosaku Yoshida, Masako Mori, Yuta Hirano, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Yoshihiro Matsumoto …

ANTICANCER RESEARCH, 35(1) 555-562, Jan, 2015 Peer-reviewed
Immunogenic Modulation of Cholangiocarcinoma Cells by Chemoimmunotherapy

Shigeo Koido, Shin Kan, Kosaku Yoshida, Shinji Yoshizaki, Kazuki Takakura, Yoshihisa Namiki, Shintaro Tsukinaga, Shunichi Odahara, Mikio Kajihara, Masato Okamoto …

ANTICANCER RESEARCH, 34(11) 6353-6361, Nov, 2014 Peer-reviewed
Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine

Shigeo Koido, Toshifumi Ohkusa, Shin Kan, Kazuki Takakura, Keisuke Saito, Hideo Komita, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama …

WORLD JOURNAL OF GASTROENTEROLOGY, 20(39) 14420-14429, Oct, 2014 Peer-reviewed

Misc.

腸内細菌と樹状細胞—Intestinal Bacteria and Dendritic Cells—特集腸内細菌と免疫,その最新情報

小井戸薫雄, 伊藤善翔, 闞鑫, 尾藤通世, 堀内三吉, 内山幹, 大草敏史

腸内細菌学雑誌 = Journal of intestinal microbiology, 36(3) 135-141, Jul, 2022
セリンプロテアーゼ阻害剤はがん細胞のIFN-γ誘導性PDL-1の発現上昇を抑制する

佐川由紀子, 林和美, 小井戸薫雄, Kan Shin, 込田英夫, 鎌田裕子, 伊藤正紀, 本間定

日本癌学会総会記事, 74回 J-1157, Oct, 2015
ゲムシタビンによるHER2発現増強効果を利用した膵癌に対する新たな分子標的療法

KAN Shin, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

東京慈恵会医科大学雑誌, 129(6) 205-205, Nov 15, 2014
ゲムシタビンによるHER2発現増強効果を利用した膵癌に対する新たな分子標的療法

KAN Shin, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

日本がん免疫学会総会プログラム・抄録集, 18th(3) 133-133, Jun 30, 2014
化学療法剤によるヒト膵癌細胞に対する免疫的細胞死の誘導

寺嶋理沙, 佐川由紀子, 鎌田裕子, KAN Shin, 伊藤正紀, 小井戸薫雄, 本間定

東京慈恵会医科大学雑誌, 127(6) 230-231, Nov 15, 2012
Immuno-chemoradiotherapy for oral cancer: Augmentation of OK-432-induced anti-tumor immunity by tegafur and radiation

Masato Okamoto, Tomoyuki Tano, Kan Shin, Sato Mitsunobu

CANCER RESEARCH, 71, Apr, 2011
TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production (vol 116, pg 571, 2005)

T Oshikawa, M Okamoto, SU Ahmed, S Furuichi, T Tano, A Sasai, S Kan, S Kasai, Y Uto, H Nagasawa …

INTERNATIONAL JOURNAL OF CANCER, 116(6) 1004-1004, Oct, 2005

Presentations

ゲムシタビンによるHER2発現増強効果を利用した膵臓癌に対する新たな分子標的療法.

カンシン

御茶ノ水がん学アカデミア第121回集会, 2016
ゲムシタビンによるHER2発現増強効果を利用した膵癌に対する新たな分子標的療法

カンシン, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

第52回日本癌治療学会学術集会, 2014
HER2 up-regulation induced by gemcitabine treatment augments antitumor effect of Trastuzumab Emtansine against pancreatic cancer.

Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Eijiro Nagasaki, Sadamu Homma

AACR, 2014
HER2陰性乳癌に対するゲムシタビンのHER2発現増強効果はトラスツズマブエムタンシンの抗腫瘍効果を増強させる

カンシン, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

第73回日本癌学会学術総会, 2014
ゲムシタビンのHER2発現増強効果を利用したHER2低発現乳癌細胞に対するトラスツズマブエムタンシンの抗腫瘍増強作用

カンシン, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

第27回日本バイオセラピィ学会学術集会総会, 2014
Gemcitabine enhanced HER2 expression and Trastuzumab Emtansine augmented anti-tumor effect against Gemcitabine-treated breast cancer cell lines with low HER2 expression

Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Eijiro Nagasaki, Sadamu Homma

第43回日本免疫学会総会・学術集会., 2014
新規分子標的治療薬Trastuzumab-Emtansineのヒト膵癌細胞に対する抗腫瘍効果

カンシン, 小井戸薫雄, 岡本正人, 林和美, 伊藤正紀, 鎌田裕子, 込田英夫, 永崎栄次郎, 本間定

第72回日本癌学会学術総会, 2013
化学療法剤による癌細胞の免疫感受性の増強

カンシン, 木村幸乃, 塚田旬, 吉崎慎二, 石田尾武文, 岡本正人, 本間定, 小井戸薫雄, 恒富亮一, 吉村清, 硲彰一, 岡正朗

第70回日本癌学会学術総会, 2011
癌細胞の主組織適合抗原(MHC)およびNKG2DL発現に及ぼす各種薬剤の影響

カンシン, 塚田旬, 木村幸乃, 岡本正人, 硲彰一, 岡正朗

第23回日本バイオセラピィ学会学術集会総会, 2010
末梢血単核球に対する抗癌剤の影響-特にTregに関する検討-

カンシン, 硲彰一, 前田和成, 佐野昭子, 園田結香, 柳井結子, 岡正朗

第30回癌免疫外科研究会, 2009
抗癌剤がCD4+FoxP3+制御性T細胞に与える影響の検討

カンシン, 硲彰一, 前田和成, 岡正朗

第68回日本癌学会学術集会, 2009
抗癌剤によるCD4+FoxP3+制御性T細胞抑制の可能

カンシン, 硲彰一, 前田和成, 吉村清, 吉野茂文, 岡正朗

第22回日本バイオセラピィ学会学術集会総会, 2009

Research Projects

膵臓がんにおける腫瘍抗原発現制御機序に関するPD-L1の関与

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2022

カンシン
膵臓がん標準化学療法の治療効果を規定する腸内細菌叢の同定

科学研究費助成事業奨励研究, 奨励研究, 日本学術振興会, Apr, 2019 - Mar, 2020

かんしん

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