Papers

International journal
Jan, 2020

Simultaneous development of IgA vasculitis and eosinophilic granulomatosis with polyangiitis.

Modern rheumatology case reports
  • Yosuke Asano
  • Yoshinori Matsumoto
  • Tatsuhiko Miyazaki
  • Akihiro Ishizu
  • Shin Morizane
  • Keigo Hayashi
  • Yuriko Yamamura
  • Sumie Hiramatsu
  • Yoshia Miyawaki
  • Michiko Morishita
  • Keiji Ohashi
  • Haruki Watanabe
  • Katsue Sunahori Watanabe
  • Tomoko Kawabata
  • Ken-Ei Sada
  • Hirofumi Makino
  • Jun Wada
  • Display all

Volume
4
Number
1
First page
63
Last page
69
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1080/24725625.2019.1673528

Immunoglobulin A (IgA) vasculitis (IgAV) is a small vessel vasculitis presenting cutaneous purpura, arthralgias and/or arthritis, acute enteritis and glomerulonephritis caused by deposition of the IgA1-mediated immune complex. Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) characterised by eosinophil-rich and granulomatous inflammation in small to medium-sized vessels. Both IgAV and EGPA are classified as autoimmune systemic vasculitis, but the pathogenesis of immune complex-mediated IgAV and that of pauci-immune EGPA are different. Here we report a rare case of simultaneous development of IgAV and EGPA presenting palpable purpura and numbness in a patient with a history of asthma. Histological examination revealed leukocytoclastic vasculitis with deposition of IgA, IgM and C3 in the upper dermis and necrotising vasculitis with eosinophilic infiltration and granulomatous formation in the lower dermis and subcutaneous fat, indicating the existence of IgAV and EGPA. Our case provides evidence of concurrent development of two different types of vasculitis, which may affect disease-associated complications, therapeutic strategy and prognosis.

Link information
DOI
https://doi.org/10.1080/24725625.2019.1673528
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33086980
ID information
  • DOI : 10.1080/24725625.2019.1673528
  • Pubmed ID : 33086980

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