論文

国際誌
2022年11月29日

Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota.

Proceedings of the National Academy of Sciences of the United States of America
  • Xuanzhong Chen
  • Daigo Hashimoto
  • Ko Ebata
  • Shuichiro Takahashi
  • Yu Shimizu
  • Ryuga Shinozaki
  • Yuta Hasegawa
  • Ryo Kikuchi
  • Hajime Senjo
  • Kazuki Yoneda
  • Zixuan Zhang
  • Shinpei Harada
  • Eiko Hayase
  • Takahide Ara
  • Hiroyuki Ohigashi
  • Yoichiro Iwakura
  • Kiminori Nakamura
  • Tokiyoshi Ayabe
  • Takanori Teshima
  • 全て表示

119
48
開始ページ
e2211230119
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.2211230119

Granulopoiesis in the bone marrow adjusts cellular output as demand for neutrophils changes. Reactive granulopoiesis is induced by profound neutropenia, but its mechanism remains to be clarified. We herein explored its mechanisms using mouse models of syngeneic hematopoietic stem cell transplantation (SCT) and 5-fluorouracil-induced neutropenia. After SCT, T cell production of IL-17A was up-regulated. Neutrophil recovery was significantly delayed in IL-17A-deficient or T cell-deficient RAG1-/- mice, and adoptive transfer of wild-type (WT) T cells facilitated neutrophil engraftment. Gut decontamination with oral antibiotics suppressed T cell production of IL-17A and impaired neutrophil recovery. Transplantation of fecal microbiota collected from neutropenic, not naive, mice promoted neutrophil recovery in these mice, suggesting that neutropenia-associated microbiota had a potential to stimulate reactive granulopoiesis. Our study uncovered a cross talk between gut microbiota and neutropenia after SCT and chemotherapy.

リンク情報
DOI
https://doi.org/10.1073/pnas.2211230119
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36409919
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860329
ID情報
  • DOI : 10.1073/pnas.2211230119
  • PubMed ID : 36409919
  • PubMed Central 記事ID : PMC9860329

エクスポート
BibTeX RIS