論文

国際誌
2020年

Disseminated Gonococcal Infection Associated with Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria: A Case Report and Literature Review.

International journal of general medicine
  • Makoto Saito
  • ,
  • Shinpei Harada
  • ,
  • Reiki Ogasawara
  • ,
  • Koh Izumiyama
  • ,
  • Akio Mori
  • ,
  • Masanobu Morioka
  • ,
  • Takeshi Kondo

13
開始ページ
403
終了ページ
406
記述言語
英語
掲載種別
DOI
10.2147/IJGM.S255298

Eculizumab has been developed as a breakthrough treatment for paroxysmal nocturnal hemoglobinuria (PNH). Not only for breakthroughs, eculizumab therapy is also known to increase the risk of invasive meningococcal infection. It has also been recently reported that, although rarely, administration of eculizumab may result in disseminated gonococcal infection (DGI). We report here a case in which a young patient who had used eculizumab for PNH developed DGI. A 22-year-old Japanese male with PNH who had been treated with eculizumab complained of high fever, mild nausea, headache and right knee joint pain. The patient was admitted and suspected to have sepsis due to meningococcal infection and began to receive ceftriaxone (CTRX). Gonococci were detected in a venous blood culture a few days later, and this case was diagnosed as DGI. CTRX was effective, and the patient was discharged. However, four weeks later, he complained of the same subjective symptoms as at the beginning and was hospitalized again. The presence of gonococcus was proven by venous blood culture, CTRX was re-administered and the patient responded. After discharge, he was counseled on safer sexual activity, including accurate and consistent use of condoms, by urologists. He has not relapsed with DGI for more than one year. When serious signs of infection occur in patients receiving eculizumab, it is recommended to consider DGI as well as invasive meningococcal infection, and CTRX should be given.

リンク情報
DOI
https://doi.org/10.2147/IJGM.S255298
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32765045
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372493
ID情報
  • DOI : 10.2147/IJGM.S255298
  • PubMed ID : 32765045
  • PubMed Central 記事ID : PMC7372493

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