Shinsuke Ishigaki

Profile Information

Affiliation: Professor, Molecular Neuroscience Research Center, Shiga University of Medical Science

Degree: 博士（医学）(名古屋大学)

Researcher number: 40378170
ORCID ID: https://orcid.org/0000-0002-9555-0659
J-GLOBAL ID: 201001053531378550
Researcher ID: I-7305-2014
researchmap Member ID: 6000026154

External link: https://mnrc2.jp/en/

神経変性疾患および認知症の病態と治療法に関する研究を行なっています。

Major Research Interests

Research Areas

Research History

May, 2022

Professor, Molecular Neuroscience Research Center, Shiga University of Medical Science
Apr, 2010 - Apr, 2022

その他, 名古屋大学医学(系)研究科(研究院)
Sep, 2005 - Mar, 2010

Postdoctral fellow, University of Massachusetts Medical School
Apr, 2004 - Aug, 2005

医員, 名古屋大学医学部附属病院
Oct, 2002 - Mar, 2004

特別研究員, 東京都臨床医学総合研究所
May, 1996 - Mar, 1998

Resident, Tokyo Metropolitan Komagome Hospital

Education

Apr, 1998 - Mar, 2002

Graduate School of Medicine, Nagoya University
Apr, 1990 - Mar, 1996

School of Medicine, Nagoya University

Committee Memberships

Apr, 2023 - Present

評議員, 神経科学学会

Major Papers

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?

Yuichi Riku, Mari Yoshida, Yasushi Iwasaki, Gen Sobue, Masahisa Katsuno, Shinsuke Ishigaki

International journal of molecular sciences, 23(24), Dec 12, 2022 Peer-reviewed
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.

Yuichi Riku, Yasushi Iwasaki, Shinsuke Ishigaki, Akio Akagi, Masato Hasegawa, Kenya Nishioka, Yuanzhe Li, Miho Riku, Takeshi Ikeuchi, Yusuke Fujioka …

Brain : a journal of neurology, 145(8) 2769-2784, Mar 11, 2022 Peer-reviewed
Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.

Yuichi Riku, Danielle Seilhean, Charles Duyckaerts, Susana Boluda, Yohei Iguchi, Shinsuke Ishigaki, Yasushi Iwasaki, Mari Yoshida, Gen Sobue, Masahisa Katsuno

International journal of molecular sciences, 22(8), Apr 8, 2021 Peer-reviewed
Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases.

Shinsuke Ishigaki, Yuichi Riku, Yusuke Fujioka, Kuniyuki Endo, Nobuyuki Iwade, Kaori Kawai, Minaka Ishibashi, Satoshi Yokoi, Masahisa Katsuno, Hirohisa Watanabe …

Brain : a journal of neurology, 143(8) 2398-2405, Aug 1, 2020 Peer-reviewedLead authorCorresponding author
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.

Kensuke Ikenaka, Shinsuke Ishigaki, Yohei Iguchi, Kaori Kawai, Yusuke Fujioka, Satoshi Yokoi, Rehab F Abdelhamid, Seiichi Nagano, Hideki Mochizuki, Masahisa Katsuno …

Journal of neuropathology and experimental neurology, 79(4) 370-377, Apr 1, 2020 Peer-reviewed
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.

Kunihiko Araki, Amane Araki, Daiyu Honda, Takako Izumoto, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Yohei Iguchi, Akitoshi Hara, Kazuhiro Ikumi …

The Journal of clinical investigation, 130(9) 3578-3593, Jul 29, 2019 Peer-reviewed
Tau isoform expression and phosphorylation in marmoset brains.

Govinda Sharma, Anni Huo, Taeko Kimura, Seiji Shiozawa, Reona Kobayashi, Naruhiko Sahara, Minaka Ishibashi, Shinsuke Ishigaki, Taro Saito, Kanae Ando …

The Journal of biological chemistry, 294(30) 11433-11444, Jul 26, 2019 Peer-reviewed
Tau Accumulation and Network Breakdown in Alzheimer's Disease.

Hirohisa Watanabe, Epifanio Bagarinao, Takamasa Yokoi, Hiroshi Yamaguchi, Shinsuke Ishigaki, Michihito Mausuda, Masahisa Katsuno, Gen Sobue

Advances in experimental medicine and biology, 1184 231-240, 2019 Peer-reviewed
Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA.

Kuniyuki Endo, Shinsuke Ishigaki, Yoshito Masamizu, Yusuke Fujioka, Akiya Watakabe, Tetsuo Yamamori, Nobuhiko Hatanaka, Atsushi Nambu, Haruo Okado, Masahisa Katsuno …

Neuroscience research, 130 56-64, May, 2018 Peer-reviewedCorresponding author
Importance of Functional Loss of FUS in FTLD/ALS.

Shinsuke Ishigaki, Gen Sobue

Frontiers in molecular biosciences, 5 44-44, 2018 Peer-reviewedLead authorCorresponding author
Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus.

Gen Sobue, Shinsuke Ishigaki, Hirohisa Watanabe

Frontiers in neuroscience, 12 473-473, 2018 Peer-reviewed
3 ' UTR Length-Dependent Control of SynGAP Isoform alpha 2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function

Satoshi Yokoi, Tsuyoshi Udagawa, Yusuke Fujioka, Daiyu Honda, Haruo Okado, Hirohisa Watanabe, Masahisa Katsuno, Shinsuke Ishigaki, Gen Sobue

CELL REPORTS, 20(13) 3071-3084, Sep, 2017 Peer-reviewedCorresponding author
Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi …

CELL REPORTS, 18(5) 1118-1131, Jan, 2017 Peer-reviewedLead authorCorresponding author
FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Yuichi Riku, Daisuke Ibi, Taku Nagai, Kiyofumi Yamada, Hirohisa Watanabe …

NATURE COMMUNICATIONS, 6 7098, May, 2015 Peer-reviewedCorresponding author
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons

Daiyu Honda, Shinsuke Ishigaki, Yohei Iguchi, Yusuke Fujioka, Tsuyoshi Udagawa, Akio Masuda, Kinji Ohno, Masahisa Katsuno, Gen Sobue

FEBS OPEN BIO, 4 1-10, 2014 Peer-reviewedCorresponding author
Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells

Kohsuke Kanekura, Shinsuke Ishigaki, Philip I. Merksamer, Feroz R. Papa, Fumihiko Urano

LABORATORY INVESTIGATION, 93(11) 1254-1258, Nov, 2013 Peer-reviewedLead author
FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD.

Yusuke Fujioka, Shinsuke Ishigaki, Akio Masuda, Yohei Iguchi, Tsuyoshi Udagawa, Hirohisa Watanabe, Masahisa Katsuno, Kinji Ohno, Gen Sobue

Scientific reports, 3 2388-2388, 2013 Peer-reviewedCorresponding author
Thioredoxin-Interacting Protein Mediates ER Stress-Induced beta Cell Death through Initiation of the Inflammasome

Christine M. Oslowski, Takashi Hara, Bryan O'Sullivan-Murphy, Kohsuke Kanekura, Simin Lu, Mariko Hara, Shinsuke Ishigaki, Lihua J. Zhu, Emiko Hayashi, Simon T. Hui …

CELL METABOLISM, 16(2) 265-273, Aug, 2012 Peer-reviewed
Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions

Shinsuke Ishigaki, Akio Masuda, Yusuke Fujioka, Yohei Iguchi, Masahisa Katsuno, Akihide Shibata, Fumihiko Urano, Gen Sobue, Kinji Ohno

SCIENTIFIC REPORTS, 2 529, Jul, 2012 Peer-reviewedLead author
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1

S. Ishigaki, S. G. Fonseca, C. M. Oslowski, A. Jurczyk, J. R. Shearstone, L. J. Zhu, M. A. Permutt, D. L. Greiner, R. Bortell, F. Urano

CELL DEATH AND DIFFERENTIATION, 17(5) 774-786, May, 2010 Peer-reviewedLead authorCorresponding author
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski, Simin Lu, Kathryn L. Lipson, Rajarshi Ghosh, Emiko Hayashi, Hisamitsu Ishihara, Yoshitomo Oka, M. Alan Permutt …

JOURNAL OF CLINICAL INVESTIGATION, 120(3) 744-755, Mar, 2010 Peer-reviewed
Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity

Shinsuke Ishigaki, Jun-ichi Niwa, Shin-ichi Yamada, Miho Takahashi, Takashi Ito, Jun Sone, Manabu Doyu, Fumihiko Urano, Gen Sobue

NEUROBIOLOGY OF DISEASE, 25(2) 331-341, Feb, 2007 Peer-reviewedLead author
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1

Kathryn L. Lipson, Sonya G. Fonseca, Shinsuke Ishigaki, Linh X. Nguyen, Elizabeth Foss, Rita Bortell, Aldo A. Rossini, Fumihiko Urano

CELL METABOLISM, 4(3) 245-254, Sep, 2006 Peer-reviewed
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders

S Ishigaki, N Hishikawa, J Niwa, S Iemura, T Natsume, S Hori, A Kakizuka, K Tanaka, G Sobue

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(49) 51376-51385, Dec, 2004 Peer-reviewedLead author
Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords - screening by molecular indexing and subsequent cDNA microarray analysis

S Ishigaki, J Niwa, Y Ando, T Yoshihara, K Sawada, M Doyu, M Yamamoto, K Kato, Y Yotsumoto, G Sobue

FEBS LETTERS, 531(2) 354-358, Nov, 2002 Peer-reviewedLead author
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity

J Niwa, S Ishigaki, N Hishikawa, M Yamamoto, M Doyu, S Murata, K Tanaka, N Taniguchi, G Sobue

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(39) 36793-36798, Sep, 2002 Peer-reviewed
X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

S Ishigaki, Y Liang, M Yamamoto, J Niwa, Y Ando, T Yoshihara, H Takeuchi, M Doyu, G Sobue

JOURNAL OF NEUROCHEMISTRY, 82(3) 576-584, Aug, 2002 Peer-reviewedLead author
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

T Yoshihara, S Ishigaki, M Yamamoto, Y Liang, J Niwa, H Takeuchi, M Doyu, G Sobue

JOURNAL OF NEUROCHEMISTRY, 80(1) 158-167, Jan, 2002 Peer-reviewed
A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity

J Niwa, S Ishigaki, M Doyu, T Suzuki, K Tanaka, G Sobue

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 281(3) 706-713, Mar, 2001 Peer-reviewed
Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells

S Ishigaki, J Niwa, T Yoshihara, N Mitsuma, M Doyu, G Sobue

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 279(2) 526-533, Dec, 2000 Peer-reviewedLead author
Significance of membrane type 1 matrix metalloproteinase expression in breast cancer

S Ishigaki, M Toi, T Ueno, H Matsumoto, M Muta, M Koike, M Seiki

JAPANESE JOURNAL OF CANCER RESEARCH, 90(5) 516-522, May, 1999 Peer-reviewedLead author

Misc.

Aberrant Interaction Between FUS and SFPQ in Neurons in a Wide Range of FTLD Spectrum Diseases

石垣診祐

Brain and Nerve, 73(9) 2398-2405, 2021
Current therapeutic strategies for tauopathy

石垣診祐, 祖父江元

医学のあゆみ, 273(1) 17-22, Apr, 2020
マーモセット脳で発現するタウのアイソフォームとリン酸化

カク安ニ, SHARMA Govinda, 木村妙子, 木村妙子, 塩澤誠司, 小林玲央奈, 小林玲央奈, 佐原成彦, 石橋みなか, 石垣診祐 …

日本生化学会大会(Web), 92nd, 2019
タウisoformの成体神経新生における役割

石垣診祐, 石垣診祐, 岩出展行, 藤岡祐介, 遠藤邦幸, 河合香里, 石橋みなか, 勝野雅央, 渡辺宏久, 宮坂知宏 …

臨床ストレス応答学会大会抄録集, 13th, 2018
The retention pattern of THK5351 pet imaging and functional network disruption associated with development of Alzheimer's disease

Yokoi T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R, Kawabata K, Hara K …

JOURNAL OF THE NEUROLOGICAL SCIENCES, 381 960-961, Oct 15, 2017
【認知症の予防と対策】前頭側頭型認知症への新しいアプローチ

石垣診祐, 祖父江元

Medical Science Digest, 42(7) 331-334, Jun, 2016
【認知症】病態生理認知症の動物モデルupdate

石垣診祐

最新医学, 71(3月増刊) 558-562, Mar, 2016
【RNA疾患-最新の病態解析から治療法展望まで-】筋萎縮性側索硬化症におけるRNA制御異常

石垣診祐, 祖父江元

Medical Science Digest, 40(7) 338-341, Jun, 2014
FUSの機能喪失はタウisoformの制御を介してFTLDの高次機能異常に関与する

石垣診祐, 藤岡祐介, 岡戸春生, 渡辺宏久, 勝野雅央, 祖父江元

日本神経学会学術大会プログラム・抄録集, 55th, 2014
TDP-43の凝集体形成におけるRNA結合障害の関与

高木伸之介, 井口洋平, 石垣診祐, 勝野雅央, 田中章景, 祖父江元

臨床神経学, 52(12) 1448-1448, Dec, 2012
ALSにおけるFUS/TLSの質的機能喪失と病態 FUS/TLSの核内高分子複合体の機能解析から

石垣診祐, 藤岡祐介, 田中章景, 祖父江元

臨床神経学, 52(12) 1603-1603, Dec, 2012
Review/Advances in Neurological Therapeutics (2011). Motor Neuron Disease.

TANAKA FUMIAKI, IGUCHI YOHEI, IKENAKA KENSUKE, ISHIGAKI SHINSUKE, KATSUNO MASAHISA, SOBUE GEN

神経治療学, 29(4) 401-403-403, Jul 25, 2012
運動ニューロンにおけるALS関連変異FUS/TLSの機能障害

石垣診祐, 藤岡祐介, 田中章景, 祖父江元

臨床神経学, 51(12) 1315-1315, Dec, 2011
Review/Advances in Neurological Therapeutics (2010). Motor Neuron Disease

TANAKA FUMIAKI, IGUCHI YOHEI, ISHIGAKI SHINSUKE, KATSUNO MASAHISA, SOBUE GEN

神経治療学, 28(4) 367-369, Jul 25, 2011
神経変性とユビキチンリガーゼ

石垣診祐, 祖父江元

老年期痴呆研究会誌(Web), 15 WEB ONLY 108-109-109, 2010
Protein Homeostasisを解明する小胞体ストレスと疾患神経変性疾患の発症にかかわる小胞体ストレスのメカニズム

石垣診祐

実験医学, 27(4) 519-525-525, Mar 1, 2009
RNAi-mediated Gene Silencing Therapy for Motor Neuron Disease.

ISHIGAKI SHINSUKE, SOBUE GEN

神経治療学, 23(1) 25-29, Jan 25, 2006
運動ニューロン疾患Up‐to‐date

山本正彦, 石垣診祐, 勝野雅央, 祖父江元

Brain Nerve, 57(4) 273-283, Apr 1, 2005
Dorfinは変異SOD1のミトコンドリア蓄積の低減を介して神経細胞死を抑制する

田中章景, 竹内英之, 丹羽淳一, 石垣診祐, 菱川望, 道勇学, 祖父江元

臨床神経学, 44(12) 1092-1092, Dec, 2004
ユビキチンと筋萎縮性側索硬化症(ALS)

石垣診祐

週刊医学のあゆみ, 211(1) 103-107-107, Oct 2, 2004

Books and Other Publications

Phase Separation in Living Cells

Ishigaki S (Role: Contributor, Functional Properties of Phase Separation and Intranuclear Complex of FUS in the Pathogenesis of ALS/FTLD)

Springer, Singapore., Oct, 2023 (ISBN: 9789819948857)

Major Professional Memberships

Research Projects

天然変性領域 (IDR) 形成を支えるスプライシング機構から俯瞰する相分離現象

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2025

増田章男, 石垣診祐
FTLDスペクトラムにおける核内RNP複合体の機能変化に基づく核酸医療の開発

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2025

石垣診祐, 増田章男, 藤岡祐介
ゴルジ体ストレスシグナルに着目した新たな老年病発症メカニズムの解析

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2024

大橋憲太郎, 石垣診祐, 高島茂雄, 天谷文昌, 内尾こずえ
Development of oligonucleotide therapeutics targeting liquid-liquid phase separation for FTLD

Japan Agency for Medical Research and Development (AMED), Apr, 2021 - Mar, 2024
Development of novel translational test batteries using FTLD model marmosets

Brain/MINDS, Japan Agency for Medical Research and Development (AMED), Apr, 2021 - Mar, 2024
脳老化に関わる小胞体選択的オートファジー基質の探索と神経老化制御への応用

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2023

大橋憲太郎, 石垣診祐, 天谷文昌, 内尾こずえ
Common pathogenesis in a wide-range of FTLD spectrum including ALS/FTLD and tauopathies

KAKENHI, Grant-in-Aid for Scientific Research (C), JST, Apr, 2018 - Mar, 2021

Shinsuke Ishigaki
多チャンネルプレーナ技術による生体組織分子解析とその神経疾患応用

戦略的創造研究推進事業（科学技術推進機構）, 日本学術振興会, Apr, 2015 - Mar, 2020

高村禅
Mechanism of tau protein aging and neurodegeneration

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019

Takashima Akihiko, Soeda Yoshiyuki, Sumioka Akio, Misonou Hiroaki, Taguchi Akiko
Adult neurogenesis in the mouse models of ALS/FTLD

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Ishigaki Shinsuke
Elucidation of dysregulation of exocytosis in sporadic amyotrophic lateral sclerosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2017

KATSUNO Masahisa
Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

Nomura Yasuyuki, Sobue Gen, Okuma Yasunobu, Kitamura Yoshihisa, Tomobe Koji, Kaneko Masayuki, Ishigaki Shinsuke, Takata Kazuyuki, Kawada Koichi

Industrial Property Rights

特許第6994711号細胞内容物の回収方法および回収装置

高村禅, 宇理須恒雄, 石垣診祐, 宇野秀隆

Profile Information

Major Research Interests

Research Areas

Research History

Education

Committee Memberships

Major Papers

Misc.

Books and Other Publications

Major Professional Memberships

Research Projects

Industrial Property Rights

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