1999年5月
Significance of membrane type 1 matrix metalloproteinase expression in breast cancer
JAPANESE JOURNAL OF CANCER RESEARCH
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- 巻
- 90
- 号
- 5
- 開始ページ
- 516
- 終了ページ
- 522
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis and invasion through the degradation of extracellular matrix (ECM). MT1-MMP (membrane type 1 matrix metalloproteinase), a membrane-type MMP, is responsible for the activation of MMP2. In this study the significance of MT1-MMP expression in human breast tumors was investigated by immunocytochemical assay, and its correlation with clinicobiological features was analyzed, MT1-MMP expression was detected in tumor cells and/or stromal cells, and there was a strong correlation between the expressions of MT1-MMP in the two cell types. Out of 183 primary tumors, 103 (56.2%) showed positive staining of MT1-MMP in tumor cells, MT1-MMP expression showed no significant correlation with any of the clinicobiological parameters examined, including hormone receptor status and angiogenesis, In postoperative survival analysis, MT1-MMP expression itself was not a significant prognostic factor. However, in the particular subgroup with the accumulation of thymidine phosphorylase (TB)-positive stromal tells, which have been activated by various stimuli, such as cytokines and hypoxia, MT1-MMP expression had a significant prognostic value, These data suggested that MT1-MMP might function cooperatively with tumor-associated stromal cells for the progression of breast cancer.
- リンク情報
- ID情報
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- ISSN : 0910-5050
- PubMed ID : 10391091
- Web of Science ID : WOS:000080650800006