論文

査読有り 国際誌
2017年10月

The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis in rats.

Pediatric surgery international
  • Shin Shinyama
  • ,
  • Tatsuru Kaji
  • ,
  • Motoi Mukai
  • ,
  • Kazuhiko Nakame
  • ,
  • Hiroshi Matsufuji
  • ,
  • Hideo Takamatsu
  • ,
  • Satoshi Ieiri

33
10
開始ページ
1109
終了ページ
1114
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00383-017-4145-9
出版者・発行元
SPRINGER

PURPOSE: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug, has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC. METHODS: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on days 0 and 1]). The effects of Daikenchuto were evaluated in four groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, and III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak's previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated. RESULTS: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7, 30.0, 30.7, and 13.3%, respectively. High-dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p = 0.04). CONCLUSION: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1007/s00383-017-4145-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28815293
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000411192900013&DestApp=WOS_CPL

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