Shiori Toba

Profile Information

Affiliation: Medical School, Hirosaki University of Health and Welfare

Degree: 博士（学術）(東京大学)

J-GLOBAL ID: 200901012953769081
researchmap Member ID: 5000092331

External link: https://www.hirosakiuhw.jp/

生体分子モーターの運動メカニズムと細胞内輸送の制御機構の解明を目的として、主に生物物理学的手法を用いてアプローチしています。また、滑脳症やパーキンソン病、レビー小体型認知症などの発生機序に関わると考えられている微小管結合タンパク質の機能解析も行っています。

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Hirosaki University of Health and Welfare
Apr, 2017 - Mar, 2021

Hirosaki University of Health and Welfare
Apr, 2009 - Mar, 2017

Graduate School of Medicine, Osaka City University
Apr, 2008 - Mar, 2009

特別研究員, 日本学術振興会
Jul, 2005 - Mar, 2008

有期研究員, 情報通信研究機構未来ICT研究センター
Mar, 2004 - Jun, 2005

Graduate School of Arts and Sciences, The University of Tokyo

Education

Apr, 2000 - Mar, 2004

総合文化研究科博士課程修了, 東京大学大学院
Apr, 1999 - Mar, 2000

生命理学専攻博士後期課程退学, 理学研究科, 名古屋大学大学院
Apr, 1997 - Mar, 1999

広域科学専攻修士課程修了, 総合文化研究科, 東京大学大学院
Apr, 1993 - Mar, 1997

Division of Natural Sciences, College of Liberal Arts, International Christian University

Papers

Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

Shiori Toba, Mingyue Jin, Masami Yamada, Kanako Kumamoto, Sakiko Matsumoto, Takuo Yasunaga, Yuko Fukunaga, Atsuo Miyazawa, Sakiko Fujita, Kyoko Itoh …

Scientific Reports, 8(1) 8019, Dec 1, 2017 Peer-reviewed
Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

Shiori Toba, Mingyue Jin, Masami Yamada, Kanako Kumamoto, Sakiko Matsumoto, Takuo Yasunaga, Yuko Fukunaga, Atsuo Miyazawa, Sakiko Fujita, Kyoko Itoh …

SCIENTIFIC REPORTS, 7(1) 16386, Nov, 2017 Peer-reviewed
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics

Mingyue Jin, Oz Pomp, Tomoyasu Shinoda, Shiori Toba, Takayuki Torisawa, Ken'ya Furuta, Kazuhiro Oiwa, Takuo Yasunaga, Daiju Kitagawa, Shigeru Matsumura …

SCIENTIFIC REPORTS, 7 39902, Jan, 2017 Peer-reviewed
Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules

Shiori Toba, Kotaro Koyasako, Takuo Yasunaga, Shinji Hirotsune

MICROSCOPY, 64(6) 419-427, Dec, 2015 Peer-reviewed
X-Ray Fiber Diffraction Recordings from Oriented Demembranated Chlamydomonas Flagellar Axonemes

Shiori Toba, Hiroyuki Iwamoto, Shinji Kamimura, Kazuhiro Oiwa

Biophysical Journal, 108(12) 2843-2853, Jun 18, 2015 Peer-reviewed
1P192 Synucleins are essential for the creation of transportable microtubules, which is required for anterograde transport of cytoplasmic dynein(12. Cell biology,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Toba Shiori, Koyasako Kotaro, Yamada Masami, Yasunaga Takuo, Kojima Hiroaki, Wanibuchi Hideki, Hirotsune Shinji

Seibutsu Butsuri, 54(1) S172, 2014
Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement

Masami Yamada, Kanako Kumamoto, Shintaro Mikuni, Yoshiyuki Arai, Masataka Kinjo, Takeharu Nagai, Yoshikazu Tsukasaki, Tomonobu M. Watanabe, Mitsuru Fukui, Mingyue Jin …

NATURE COMMUNICATIONS, 4 2033, Jun, 2013 Peer-reviewed
Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

Jing Yan, Dan L. Chao, Shiori Toba, Kotaro Koyasako, Takuo Yasunaga, Shinji Hirotsune, Kang Shen

eLife, 2013(2) e00133, Mar 6, 2013 Peer-reviewed
Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.

Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka …

Scientific reports, 3 1224-1224, 2013 Peer-reviewed
Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization

Takako Takitoh, Kanako Kumamoto, Chen-Chi Wang, Makoto Sato, Shiori Toba, Anthony Wynshaw-Boris, Shinji Hirotsune

JOURNAL OF NEUROSCIENCE, 32(32) 11050-11066, Aug, 2012 Peer-reviewed
A unique role of dynein and nud family proteins in corticogenesis

Shiori Toba, Shinji Hirotsune

NEUROPATHOLOGY, 32(4) 432-439, Aug, 2012 Peer-reviewed
X-ray diffraction recording from single axonemes of eukaryotic flagella

Masaya Nishiura, Shiori Toba, Daisuke Takao, Daisuke Miyashiro, Hitoshi Sakakibara, Tatsuhito Matsuo, Shinji Kamimura, Kazuhiro Oiwa, Naoto Yagi, Hiroyuki Iwamoto

JOURNAL OF STRUCTURAL BIOLOGY, 178(3) 329-337, Jun, 2012 Peer-reviewed
2A1436 Regulation of cytoplasmic dynein-motility on microtubules by LIS1 revealed by electron-computed tomography(Molecular Motors II:Dynein,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

Toba Shiori, Koyasako Kotaro, Hirotsune Shinji, Yasunaga Takuo

Seibutsu Butsuri, 52 S38, 2012
Distinct roles of 1 alpha and 1 beta heavy chains of the inner arm dynein I1 of Chlamydomonas flagella

Shiori Toba, Laura A. Fox, Hitoshi Sakakibara, Mary E. Porter, Kazuhiro Oiwa, Winfield S. Sale

MOLECULAR BIOLOGY OF THE CELL, 22(3) 342-353, Feb, 2011 Peer-reviewed
1M1624 High Resolution Electron Tomography Analysis of the Cytoplasmic Dynein and Microtubule Complex(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan)

Koyasako Kotaro, Toba Shiori, Hirotsune Shinji, Yasunaga Takuo

Seibutsu Butsuri, 51 S65, 2011
mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1

Masami Yamada, Shiori Toba, Takako Takitoh, Yuko Yoshida, Daisuke Mori, Takeshi Nakamura, Atsuko H. Iwane, Toshio Yanagida, Hiroshi Imai, Li-yuan Yu-Lee …

EMBO JOURNAL, 29(3) 517-531, Feb, 2010 Peer-reviewed
1P167 1B1240 Ring-sliding Walking of Cytoplasmic Dynein and Its Regulation by LIS1(Molecular motor,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

Toba Shiori, Yamada Masami, Yasunaga Takuo, Hirotsune Shinji

Seibutsu Butsuri, 50(2) S48, 2010
Biophysical Measurements on Axonemal Dyneins

Hiroaki Kojima, Shiori Toba, Hitoshi Sakakibara, Kazuhiro Oiwa

CILIA: MOTORS AND REGULATION, 92 83-105, 2009 Peer-reviewed
Direction and speed of microtubule movements driven by kinesin motors arranged on catchin thick filaments

Toshiki Taba, Masaki Edamatsu, Shiori Toba, Keitaro Shibata, Yasuhiro Imafuku, Yoko Yano Toyoshima, Katsuhisa Tawada, Akira Yamada

CELL MOTILITY AND THE CYTOSKELETON, 65(10) 816-826, Oct, 2008 Peer-reviewed
LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

Masami Yamada, Shiori Toba, Yuko Yoshida, Koji Haratani, Daisuke Mori, Yoshihisa Yano, Yuko Mimori-Kiyosue, Takeshi Nakamura, Kyoko Itoh, Shinji Fushiki …

EMBO JOURNAL, 27(19) 2471-2483, Oct, 2008 Peer-reviewed

Misc.

Implementation report: Students visit the Aomori Prefecture Disaster Relief Aviation Unit and the Aomori Firefighter Academy to learn about recruit training

2(1) 117-123, 2021
Implementation report: 10-km group run and physical fitness exercise held as an event of the Department of Emergency Medical Technology

2(1) 111-116, 2021
地元消防機関と連携した応急手当講習への救急救命士学生の参加との意義と展望

鳴海圭佑, 齋藤駿佑, 中川貴仁, 小山内健介, 若松淳, 釜萢一正, 木下裕太, 立岡伸章, 鳥羽栞, 平井歩

日本臨床救急医学会雑誌, 23(3) 388-388, Aug, 2020
Implementation report : Volunteer activities for First-Aid Action at the Hirosaki Shirakami Apple Marathon

1(1) 63-68, Mar, 2020
Implementation report : Elementary student work experience program as an emergency life-saving technician

1(1) 73-78, Mar, 2020
事業実施報告救急救命学科企画救急救命学科と青森県ドクターヘリ並びに消防機関との合同訓練開催 (特集弘前医療福祉大学短期大学部平成30年度事業実施報告)

鳥羽栞, 中川貴仁

弘前医療福祉大学短期大学部紀要 = Journal of Hirosaki University of Health and Welfare Junior College, 7(1) 27-29, Mar 29, 2019
Trial software of server connection type application for physiology learning support for medical service workers

鳥羽栞, 柏谷都人喜, 小松裕卓, 小屋迫光太郎

弘前医療福祉大学短期大学部紀要, 7(1) 1-7, Mar 29, 2019
微小管結合タンパク質アルファシヌクレインの神経軸索内輸送における機能解析

鳥羽栞, 金明月, 山田雅巳, 松本早紀子, 安永卓生, 福永優子, 宮澤淳夫, 小嶋寛明, 新井由之, 永井健治 …

Dementia Japan, 32(3) 426-426, Sep, 2018
Activity of Regional Branch

鳥羽栞, 田中良和, 佐々木一夫

Seibutsu Butsuri, 58(6) 329-330, 2018
α-synucleinは固有機能を有する非定型微小管と結合する(Alpha-synuclein binds unconventional microtubules that have a unique function)

鳥羽栞, 金明月, 山田雅巳, 安永卓生, 福永優子, 宮澤淳夫, 小嶋寛明, 新井由之, 永井健治, 広常真治

Dementia Japan, 30(4) 595-595, Oct, 2016
1SH-01 Three-Dimensional Structure Reconstructed by Electron Tomography Revealed How LIS1 Regulate the Motility of the Cytoplasmic Dynein(1SH Visualizing proteins in action -frontiers in biomolecular imaging-,The 49th Annual Meeting of the Biophysical Society of Japan)

Toba Shiori

Seibutsu Butsuri, 51 S7, 2011
生体モーターの多様性と同一性ダイニンの運動様式の多様性とその分子機序(Unique characteristcs of motility found in cytoplasmic dynein)

鳥羽栞

生物物理, 47(Suppl.1) S18-S18, Nov, 2007
Conformational changes of flagellar axonemes revealed by fiber diffraction study of flagella from Chlamydomonas strains

Shiori Toba, Hiroyuki Iwamoto, Tetsuro Fujisawa, Hitoshi Sakakibara, Kazuhiro Oiwa

BIOPHYSICAL JOURNAL, 500A-500A, Jan, 2007
2P160 Direction and speed of microtubule moving along kinesin motors arranged on catchin thick filaments(Molecular motors,Oral Presentations)

Taba Toshiki, Edamatsu Masaki, Toba Shiori, Imafuku Yasuhiro, Yano Toyoshima Yoko, Tawada Katsuhisa, Yamada Akira

Seibutsu Butsuri, 47(Suppl.1) S153-S153, Nov, 2007
S13H1 Unique characteristcs of motility found in cytoplasmic dynein(Common mechanism found in diversity among various biological motors)

Toba Shiori

Seibutsu Butsuri, 47 S18, 2007
2P160 Direction and speed of microtubule moving along kinesin motors arranged on catchin thick filaments(Molecular motors,Oral Presentations)

Taba Toshiki, Edamatsu Masaki, Toba Shiori, Imafuku Yasuhiro, Yano Toyoshima Yoko, Tawada Katsuhisa, Yamada Akira

Seibutsu Butsuri, 47, 2007
2P167 Conformational changes of flagellar axonemes of Chlamydomonas studied by x-ray fiber diffraction analysis(Molecular motors,Poster Presentations)

Toba Shiori, Iwamoto Hiroyuki, Sakakibara Hitoshi, Oiwa Kazuhiro

Seibutsu Butsuri, 47 S154, 2007
2P173 Distinct Properties of the 1α and 1β Heavy Chains of the Inner-Arm Dynein I1 of Chlamydomonas Flagella(Molecular motors,Poster Presentations)

Toba Shiori, Fox Laura A., Oiwa Kazuhiro, Porter Mary E., Sale Winfield S., Sakakibara Hitoshi

Seibutsu Butsuri, 47 S156, 2007
I Molecular Mechanism of Axonemal Dyneins Studied with Single Molecule Nanometry(Functional Nanometry of Biological Macromolecule)

Sakakibara H., Kojima H., Toba S., Oiwa K.

Annual review, Graduate School of Material Science and Graduate School of Life Science, University of Hyogo, 17 141-141, Oct 10, 2006
III Single-Molecule Enzymology and Nanometry of ATPase(Functional Nanometry of Biological Macromolecule)

Oiwa K., Kojima H., Tominaga M., Shitaka Y., Toba S.

Annual review, Graduate School of Material Science and Graduate School of Life Science, University of Hyogo, 17 142-142, Oct 10, 2006

Presentations

電子顕微鏡によって明らかになったシヌクレインタンパク質の分子特性から細胞内輸送における役割を探る

鳥羽栞

第53回日本生物物理学会 (金沢), Sep, 2015 Invited
電子線トモグラフィー法により明らかになったLIS1による細胞質ダイニンの運動活性制御メカニズム

鳥羽栞

第50回日本生物物理学会 {名古屋）, Sep, 2012
電子線トモグラフィーを用いた３次元再構成で明らかになったLIS1による細胞質ダイニンの制御機構

鳥羽栞

第49回日本生物物理学会 (姫路) シンポジウム, Sep, 2011 Invited
Distinct roles of 1α and 1β Heavy Chains of the I1 Inner Arm Dynein of Chlamydomonas Flagella

TOBA, Shiori

The 48th ASCB Annual Meeting (San Francisco), Dec, 2008
Mechanical and enzymatic properties of the heterodimeric axonemal dynein-f

TOBA, Shiori

2nd International Symposium on Bio-nanosystems (Tokyo), Sep, 2008 Invited
ヘテロ２量体である鞭毛内腕ダイニン亜種fの運動特性

鳥羽栞

特定領域「生体ナノシステム」下田ダイニン分子研究会 (下田), Aug, 2008 Invited
活性の異なる２つのモーター部を持つ軸糸ダイニンｆの運動特性から鞭毛内機能を探る

鳥羽栞

第5回生命・情報セミナー (東京大学), Aug, 2008 Invited
The Heterodimeric Axonemal Dynein-f : Its Mechanical and Enzymatic Properties and Possible Roles in Beating of Flagellar Axonemes

TOBA, Shiori

Biophysical Society 52th Annual Meeting (Long Beach), Mar, 2008 Invited
ダイニンの運動様式の多様性とその分子機序

鳥羽栞

第45回日本生物物理学会年会 (横浜) シンポジウム, Dec, 2007 Invited
Single Molecule Imaging of Axonemal Dynein-f

TOBA, Shiori

The 3rd Workshop of the UK-Japan Bionano technology Collaboration (Oxford), Sep, 2007 Invited
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein

Toba S, Watanabe TM, Yamaguchi L, Toyoshima YY, Higuchi H

Seminar of UT Southwestern Medical Center (Dallas), Nov, 2006 Invited
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein

TOBA, Shiori

Biophysical Society 50th Annual Meeting (Salt Lake City), Mar, 2006
Single molecules of cytoplasmic dynein produce 8-nm steps and 7-pN force

TOBA, Shiori

International Workshop Dynein (Kobe), Oct, 2005 Invited
細胞質ダイニンの1分子運動特性

鳥羽栞

夏のダイニン特訓セミナー (蔵王), Jun, 2005 Invited
Properties of Double- and Single-headed Cytoplasmic dynein

TOBA, Shiori, TOYOSHIM, Y. Yoko

COE International Conference 2003 (Hakone), Oct, 2003

Teaching Experience

Professional Memberships

Research Projects

Clarify the pathogenic mechnism of microlissencephaly

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Jin Mingyue, HIROTSUNE Shinji, MATSUMOTO Sakiko, YAMADA Masami, YASUNAGA Takuo, MIYADA Takaki, OIWA Kazuhiro, FURUTA Ken'ya, TOBA Shiori, MIYAZAWA Atsuo, NAGAI Kakeharu, REVERSADE Bruno, POMP Oz
Alpha-synuclein binds unconventional microtubules that have a unique function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2015 - 2017

Toba Shiori, Jin Mingyue, Yamada Masami, Matsumoto Sakiko, Yasunaga Takuo, Fukunaga Yuko, Miyazawa Atsuo, Kojima Hiroaki, Arai Yoshiyuki, Nagai Takeharu, Hirotsune Shinji
神経変性疾患関連タンパク質シヌクレインの制御機構の解析

医学研究助成, 大阪難病研究財団, Jun, 2015 - May, 2016

鳥羽栞
滑脳症モデルマウスを用いたカルパイン阻害薬による滑脳症治療法の開発

国内研究室相互の訪問研究プログラム, 包括型脳科学研究推進支援ネットワーク, Oct, 2011 - Dec, 2011

鳥羽栞
染色体分配機構の破綻と発がん：細胞質ダイニンの制御機構の解明

平成２１年度ガン研究助成奨励金, 大阪対ガン協会, Apr, 2009 - Mar, 2010

鳥羽栞
ナノメーター空間配置制御による軸糸ダイニンの協働性の創出

平成20年度特別研究員奨励費, 日本学術振興会, Apr, 2008 - Mar, 2009

鳥羽栞

Social Activities

出身県回帰支援センター関連フェイスブックに研究業績を紹介

Official expert

ふるさと回帰支援センター関連フェイスブック, 2015
新学術領域公式ブログに研究成果を紹介

Official expert

新学術領域「運動マシナリー」総括班フェイスブック, 2014
日本生物物理学会シンポジウム開催に関する記事

Official expert

科学新聞12月４日号掲載, 2008

Media Coverage

学術雑誌に掲載された自論文のティザー広告を作製

Biophysical Journal webpage slider, 2015 Internet
産学連携を目指した産業用シーズを掲載

大阪市立大学医学部シーズ集, 2015 Promotional material
研究助成に対してのコメントと得られた成果について掲載

包括脳ネットワーク, 包括脳ネットワークニュースレターNo.8, 2014 Promotional material
産学連携を目指した産業用シーズを掲載

大阪市立大学医学部シーズ集, 2013 Promotional material

Other

第53回日本生物物理学会

Sep, 2015 - Sep, 2015

シンポジウム「ナノとマクロを繋ぐ生物電子顕微鏡アプローチ」主催
ISAO (大阪市立大学医学部国際医学生団体)の紹介による交換留学生の指導

Jan, 2013 - Jan, 2013

交換留学生の研究指導 (英語）
第49回日本生物物理学会

Sep, 2011 - Sep, 2011

シンポジウム「タンパク質の働く姿をみる！～生体分子の可視化最前線～」主催
第45回日本生物物理学会

Dec, 2007 - Dec, 2007

シンポジウム「生体分子モーターの多様性と同一性」主催
戦略的国際科学技術協力推進事業（SICP)

2007 - 2007

2007年～2009年 Dr. Justin E. Molloy研究室にて共同研究 MRC National Institute for Medical Research (London)に断続的にのべ６か月程度滞在

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