2017年4月
Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.
The Journal of antibiotics
- 巻
- 70
- 号
- 4
- 開始ページ
- 395
- 終了ページ
- 399
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ja.2016.164
- 出版者・発行元
- JAPAN ANTIBIOTICS RESEARCH ASSOC
A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.
- リンク情報
- ID情報
-
- DOI : 10.1038/ja.2016.164
- ISSN : 0021-8820
- PubMed ID : 28096549
- Web of Science ID : WOS:000397547900008