Aug, 2013
Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle.
Microbiology and immunology
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- Volume
- 57
- Number
- 8
- First page
- 600
- Last page
- 4
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/1348-0421.12073
In the present study, we monitored Foxp3(+) T cells in bovine leukemia virus (BLV)-infected cattle. By flow cytometric analysis, the proportion of Foxp3(+) CD4(+) cells from persistent lymphocytotic cattle was significantly increased compared to control and AL cattle. Interestingly, the proportion of Foxp3(+) CD4(+) cells correlated positively with the increased number of lymphocytes, virus titer and virus load, whereas it inversely correlated with IFN-γ mRNA expression, suggesting that Foxp3(+) CD4(+) T cells in cattle have a potentially immunosuppressive function. Further studies are necessary to elucidate the detailed mechanism behind the increased Treg during BLV infection.
- Link information
- ID information
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- DOI : 10.1111/1348-0421.12073
- Pubmed ID : 23945026