Hidekazu Shirota

J-GLOBAL         Last updated: Oct 4, 2018 at 23:33
Hidekazu Shirota
Tohoku University

Research Interests


Research Areas

  • Basic medicine / Immunology / Tumor immunology

Awards & Honors

Technology Transfer Award, National Cancer Institute, NIH

Published Papers

Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors.
Ouchi K, Takahashi S, Chikamatsu S, Ito S, Takahashi Y, Kawai S, Okita A, Kasahara Y, Okada Y, Imai H, Komine K, Saijo K, Takahashi M, Shirota H, Takahashi M, Gamoh M, Ishioka C.
Int J Clin Oncol.   23(4) 790-798   Aug 2018   [Refereed]
Efficacy and Safety of Trastuzumab in Combination with S-1 and Cisplatin Therapy for Japanese Patients with HER2-Positive Advanced Gastric Cancer: Retrospective Analysis.
Okita A, Imai H, Takahashi M, Takahashi H, Umegaki S, Kawamura Y, Hiraide S, Ouchi K, Sato Y, Okada Y, Komine K, Saijo K, Takahashi S, Takahashi M, Shirota H, Ohori H, Gamoh M, Ishioka C.
Tohoku J Exp Med.   245(2) 123-129   Jun 2018   [Refereed]
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.
Nie Y, He J, Shirota H, Trivett AL, Yang, Klinman DM, Oppenheim JJ, Chen X.
Sci Signal.   11 511   Jan 2018   [Refereed]
IL-4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model.
Ito SE, Shirota H, Kasahara Y, Saijo K, Ishioka C.
Cancer Immunol Immunother.   66(11) 1485-1496   Nov 2017   [Refereed]
The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: A retrospective, single institutional study.
Takahashi M, Takahashi M, Komine K, Yamada H, Kasahara Y, Chikamatsu S, Okita A, Ito S, Ouchi K, Okada Y, Imai H, Saijo K, Shirota H, Takahashi S, Mori T, Shimodaira H, Ishioka C.
PLoS One   12(6) e0179694   Jun 2017   [Refereed]
Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis.
Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.
PLoS One   12(5) e0176972   May 2017   [Refereed]
IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity.
Shirota H, Klinman DM, Ito SE, Ito H, Kubo M, Ishioka C.
Cancer Immunol Res.   5(1) 61-71   Jan 2017   [Refereed]
Kobayashi A, Takahashi M, Imai H, Akiyama S, Sugiyama S, Komine K, Saijo K, Takahashi M, Takahashi S, Shirota H, Sato N, Fujishima F, Shuin T, Shimodaira H, Ishioka C.
Intern Med.   55(6) 629-634   Jun 2016   [Refereed]
Imai H, Komine K, Takahashi S, Saijo K, Okada Y, Kobayashi A, Okita A, Chikamatsu S, Kasahara Y, Takahashi M, Oishi T, Shirota H, Takahashi M, Shimodaira H, Ishioka C.
Chemotherapy.   61(5) 262-268   May 2016   [Refereed]
Imai H, Shirota H, Okita A, Komine K, Saijo K, Takahashi M, Takahashi S, Takahashi M, Shimodaira H, Ishioka C.
Chemotherapy.   61(3) 111-116   Dec 2015   [Refereed]
CpG Oligonucleotides as Cancer Vaccine Adjuvants.
Shirota H, Tross D, Klinman DM.
Vaccines   3(2) 390-407   May 2015   [Refereed]
Wang J, Shirota Y, Bayik D, Shirota H, Tross D, Gulley JL, Wood LV, Berzofsky JA, Klinman DM.
J Immunol.   194(9) 4215-4221   May 2015   [Refereed]
Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
J Autoimmun.   53 33-45   Sep 2014   [Refereed]
Shirota H, Klinman DM.
Expert Rev Vaccines.   13(2) 299-312   Feb 2014   [Refereed]
Shirota H, Klinman DM.
Methods Mol Biol.   1139 337-344   2014   [Refereed]
Shirota H, Klinman DM.
Immunotherapy   5(8) 787-789   Aug 2013   [Refereed]
Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.
J Immunol.   191(2) 865-874   Jul 2013   [Refereed]
Kobayashi N, Hong C, Klinman DM, Shirota H
J Immunol.   190(4) 1882-1889   Feb 2013   [Refereed]
Shirota H, Klinman DM.
OncoImmunology   1(5) 780-782   Aug 2012   [Refereed]
Shirota H, Klinman DM.
Cancer Immunol Immunother.   60(5) 659-669   May 2011   [Refereed]
Savan R, McFarland AP, Reynolds DA, Feigenbaum L, Ramakrishnan K, Karwan M, Shirota H, Klinman DM, Dunleavy K, Pittaluga S, Anderson SK, Donnelly RP, Wilson WH, Young HA.
Blood.   117(2) 575-584   Jan 2011   [Refereed]
Klaschik S, Tross D, Shirota H and Klinman DM.
Mol Immunol.   47(6) 1317-1324   Jun 2010   [Refereed]
Klinman DM, Klaschik S, Tross D, Shirota H and Steinhagen F.
Vaccine   28(16) 2801-2805   Apr 2010   [Refereed]
Klinman DM, Klaschik S, Tomaru K, Shirota H, Tross D, Ikeuchi H.
Vaccine.   28(8) 1919-1923   Feb 2010   [Refereed]
Klinman DM, Tross D, Klaschik S, Shirota H, Sato T.
Ann N Y Acad Sci.   1175 80-88   Sep 2009   [Refereed]
Shirota H, Petrenko L, Hattori T, Klinman DM.
Vaccine   27(15) 2144-2149   Mar 2009   [Refereed]
Klinman D, Shirota H, Tross D, Sato T, Klaschik S.
J Leukoc Biol.   84(4) 958-964   Oct 2008   [Refereed]
Potential of Transfected Muscle Cells to Contribute to DNA Vaccine Immunogenicity.
Shirota H, Petrenko L, Hong C, Klinman DM.
J Immunol.   179(1) 329-336   Jul 2008   [Refereed]
Shirota H, Ishii KJ, Takakuwa H, Klinman DM.
Immunology.   118(3) 302-310   Jul 2006   [Refereed]
Klinman DM, Gursel I, Klaschik S, Dong L, Currie D, Shirota H.
Ann N Y Acad Sci.   1058 87-95   Nov 2005   [Refereed]
Shirota H, Gursel I, Gursel M, Klinman DM.
J Immunol.   174(8) 4579-4583   Nov 2005   [Refereed]
CpG oligodeoxynucleotides enhance neonatal resistance to Listeria infection.
Ito S, Ishii KJ, Gursel M, Shirota H, Ihata A, Klinman DM.
J Immunol.   174(2) 777-782   Jan 2005   [Refereed]
Sano K, Shirota H.
Allergol Int.   54(1) 17-23   2005   [Refereed]
Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling.
Shirota H, Gursel M, Klinman DM.
J Immunol.   173(8) 5002-5007   Oct 2004   [Refereed]
Ito S, Ishii KJ, Shirota H, Klinman DM.
Infect Immun.   72(6) 3543-3548   Jun 2004   [Refereed]
Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner.
Sano K, Shirota H, Terui T, Hattori T, Tamura G.
J Immunol.   170(5) 2367-2373   Mar 2003   [Refereed]
B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12.
Shirota H, Sano K, Hirasawa N, Terui T, Ohuchi K, Hattori T, Tamura G.
J Immunol.   169(2) 787-794   Jul 2002   [Refereed]
TGF-b-producing CD4+ mediastinal lymph node cells obtained from mice tracheally tolerized to ovalbumin (OVA) suppresses both Th1- and Th2-induced cutaneous inflammatory responses to OVA by different mechanisms.
Terui T., K. Sano, H. Shirota, N. Kunikata, M. Ozawa, M. Okada, M. Honda, G. Tamura, H. Tagami.
J. Immunol.   167(7) 3661-3667   Oct 2001   [Refereed]
Terui T., K. Sano, M. Okada, H. Shirota, M Honda, M Ozawa, N Hirasawa, G. Tamura, H. Tagami.
J. Invet. Dermatol.   117(2) 236-243   Aug 2001   [Refereed]
Novel Roles of CpG Oligodeoxynucleotides as a Leader for the Sampling and Presentation of CpG-Tagged Ag by Dendritic Cells.
Shirota H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, K. Shirato, G. Tamura.
J. Immunol.   167(1) 66-74   Jul 2001   [Refereed]
Regulation of Murine Airway Eosinophilia and Th2 Cells by Antigen-Conjugated CpG Oligodeoxynucleotides as a Novel Antigen-Specific Immunomodulator.
Shirota H., K. Sano, T. Kikuchi, G. Tamura, K. Shirato.
J. Immunol.   164(11) 5575-5582   Jun 2000   [Refereed]
Regulation of T-helper cell type 2 and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs.
Shirota H., K. Sano, T. Kikuchi, G. Tamura, K. Shirato.
Am. J. Respir. Cell Mol. Biol.   22(2) 176-182   Feb 2000   [Refereed]
Transforming growth factor-β secreted from CD4+ T cells ameliorates antigen-induced eosinophilic inflammation: novel high-dose tolerance in the trachea.
Haneda K., K. Sano, G. Tamura, H. Shirota, Y. Ohkawara, T. Sato, S. Habu, K. Shirato.
Am. J. Respir. Cell Mol.   21(2) 268-274   Aug 1999   [Refereed]

Books etc

Immunopotentiators in Modern Vaccines Second Edition
Shirota H, Klinman DM. (Part:Joint Work, P. 163-198)
Science & Technology Books, Life Science Academic Press/Elsevier.   2018   
Inflammation / From Molecular and Cellular Mechanisms to the Clinic"
Klinman DM, Shirota H. (Part:Joint Work, p. 143-174)
Wiley-VCH Verlag GmbH & Co. KGaA,   2017   
Nucleic Acids in Innate Immunity
Klinman DM, Currie D, Fujimoto C, Gery I, and Shirota H. (Part:Joint Work, P.101-112)
CRC Press   May 2008   
Vaccine Adjuvants and Delivery Systems
Klinman DM, Currie D and Shirota H. (Part:Joint Work, P. 157-174)
Manmohan Singh.   Nov 2006   


特願E-266-2009/0 : Compositions and Methods for the Treatment of Cancer
Shirota H, Klinman DM.