論文

国際誌
2021年

Treatment Outcome of External Auditory Canal Carcinoma: The Utility of Lateral Temporal Bone Resection.

Frontiers in surgery
  • Kohei Saijo
  • Yushi Ueki
  • Ryoko Tanaka
  • Yusuke Yokoyama
  • Jo Omata
  • Takeshi Takahashi
  • Hisayuki Ota
  • Ryusuke Shodo
  • Keisuke Yamazaki
  • Takafumi Togashi
  • Ryuichi Okabe
  • Hiroshi Matsuyama
  • Kohei Honda
  • Yuichiro Sato
  • Yuka Morita
  • Kuniyuki Takahashi
  • Arata Horii
  • 全て表示

8
開始ページ
708245
終了ページ
708245
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fsurg.2021.708245

We examined the role of lateral temporal bone resection (LTBR) in the treatment of external ear canal (EAC) carcinoma between 2007 and 2018. The estimated 3-year disease-free survival (DFS) and disease-specific survival (DSS) according to the tumor stage and treatments were investigated in 36 patients with EAC squamous cell carcinoma. T stage classification according to the University of Pittsburgh staging system was as follows: 14 patients in T1, four patients in T2, nine patients in T3, and nine patients in T4. The 3-year DFS rate was 77.4% for T1 tumors, 100% for T2, 44.4% for T3 tumors, and 11.1% for T4 tumors (p < 001). The 3-year DSS rate was 100% for T1/T2 tumors, 87.5% for T3 tumors, and 11.1% for T4 tumors (p < 0.01). T1/T2 patients received mostly LTBR. Among nine T3 tumors, five patients (56%) received LTBR combined with preoperative chemotherapy and/or postoperative radiation (RT). Four of them had negative surgical margin and survived with no evidence of disease. The DFS of T3 patients who underwent concurrent chemoradiotherapy and LTBR was 0 and 80%, respectively (p = 0.048). For T1/T2 tumors, surgery achieved an excellent outcome. For T3 tumors, LTBR achieved negative surgical margin and showed good survival when combined with preoperative chemotherapy and/or postoperative RT. In contrast, the prognosis of T3 patients who could not undergo surgery was as poor as that of T4 patients. Therefore, in addition to subtotal temporal bone resection, LTBR-based treatment strategy may be a treatment option for limited cases of T3 patients.

リンク情報
DOI
https://doi.org/10.3389/fsurg.2021.708245
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34527695
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435738
ID情報
  • DOI : 10.3389/fsurg.2021.708245
  • PubMed ID : 34527695
  • PubMed Central 記事ID : PMC8435738

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