2016年2月
Evolutionary patterns of genic DNA methylation vary across land plants
NATURE PLANTS
- ,
- ,
- 巻
- 2
- 号
- 2
- 開始ページ
- 15222
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/NPLANTS.2015.222
- 出版者・発行元
- NATURE PUBLISHING GROUP
Little is known about patterns of genic DNA methylation across the plant kingdom or about the evolutionary processes that shape them. To characterize gene-body methylation (gbM) within exons, we have gathered single-base resolution methylome data that span the phylogenetic breadth of land plants. We find that a basal land plant, Marchantia polymorpha, lacks any evident signal of gbM within exons, but conifers have high levels of both CG and CHG (where H is A, C or T) methylation in expressed genes. To begin to understand the evolutionary forces that shape gbM, we first tested for correlations in methylation levels across orthologues(1,2). Genic CG methylation levels, but not CHG or CHH levels, are correlated across orthologues for species as distantly related as ferns and angiosperms. Hence, relative levels of CG methylation are a consistent property across genes, even for species that diverged similar to 400 million years ago(3,4). In contrast, genic CHG methylation correlates with genome size, suggesting that the host epigenetic response to transposable elements also affects genes. Altogether, our data indicate that the evolutionary forces acting on DNA methylation vary substantially across species, genes and methylation contexts.
- リンク情報
- ID情報
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- DOI : 10.1038/NPLANTS.2015.222
- ISSN : 2055-026X
- eISSN : 2055-0278
- PubMed ID : 27249194
- Web of Science ID : WOS:000375393200008