論文

国際誌
2018年

A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer.

Oncology
  • Rie Kondo
  • ,
  • Satoshi Watanabe
  • ,
  • Satoshi Shoji
  • ,
  • Kosuke Ichikawa
  • ,
  • Tetsuya Abe
  • ,
  • Junko Baba
  • ,
  • Junta Tanaka
  • ,
  • Hiroki Tsukada
  • ,
  • Masaki Terada
  • ,
  • Kazuhiro Sato
  • ,
  • Yoshie Maruyama
  • ,
  • Masato Makino
  • ,
  • Akira Hirata
  • ,
  • Hiroshi Tanaka
  • ,
  • Toshiyuki Koya
  • ,
  • Hirohisa Yoshizawa
  • ,
  • Toshiaki Kikuchi

94
4
開始ページ
223
終了ページ
232
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000486622

OBJECTIVE: Chemotherapy with irinotecan plus cisplatin has shown promise in chemo-naïve small-cell lung cancer (SCLC) patients. However, irinotecan treatment for relapsed or refractory SCLC has not been adequately evaluated. This phase II study evaluated the appropriate treatment schedule of irinotecan as a single agent. This study was designed to determine the antitumor activity, toxicity, and survival in previously treated SCLC patients. METHODS: Previously treated SCLC patients with at least one platinum-based regimen received irinotecan (100 mg/m2) on days 1 and 8, every 3 weeks, until disease progression. The assessment of the response rate was the primary endpoint. RESULTS: Thirty patients were enrolled, with an objective response rate of 41.3% (95% confidence interval [CI] 25.5-59.3), and a disease control rate of 69%. Median progression-free and overall survival was 4.1 months (95% CI, 2.2-5.4) and 10.4 months (95% CI, 8.1-14), respectively. The grade 3/4 hematological toxicities were neutropenia (36.7%), thrombocytopenia (3.3%), anemia (13.3%), and febrile neutropenia (6.6%). There were no grade 4 nonhematological toxicities. Frequent grade 3 nonhematological toxicities included diarrhea (10%), anorexia (6.6%), and hyponatremia (6.6%). CONCLUSIONS: This phase II study showed a high objective response rate and long survival. Irinotecan monotherapy schedule used was well tolerated, and could be an active treatment option for these patients.

リンク情報
DOI
https://doi.org/10.1159/000486622
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29444512
ID情報
  • DOI : 10.1159/000486622
  • PubMed ID : 29444512

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