2018年9月11日
Three-dimensional motion analysis for comprehensive understanding of gait characteristics after sciatic nerve lesion in rodents.
Scientific reports
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- 巻
- 8
- 号
- 1
- 開始ページ
- 13585
- 終了ページ
- 13585
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-018-31579-z
Rodent models of sciatic nerve lesion are regularly used to assess functional deficits in nerves. Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established. We used a three-dimensional motion analysis to investigate gait deficits after sciatic nerve lesion in rats. This enabled us to depict the distorted gait motion using both traditional parameters and novel readouts that are specific for the three-dimensional analysis. Our results suggest that three-dimensional motion analysis facilitates a comprehensive understanding of the gait impairment specifically, but not limited to, a sciatic lesion rat model. A broad application of these methods will improve understanding and standardized motor assessment.
- リンク情報
- ID情報
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- DOI : 10.1038/s41598-018-31579-z
- PubMed ID : 30206259
- PubMed Central 記事ID : PMC6133925