論文

査読有り
2016年

Prognostic value of fluorine-18 fludeoxyglucose positron emission tomography parameters differs according to primary tumour location in small-cell lung cancer

BRITISH JOURNAL OF RADIOLOGY
  • Tomomi Nobashi
  • ,
  • Sho Koyasu
  • ,
  • Yuji Nakamoto
  • ,
  • Takeshi Kubo
  • ,
  • Takayoshi Ishimori
  • ,
  • Young H. Kim
  • ,
  • Akihiko Yoshizawa
  • ,
  • Kaori Togashi

89
1059
開始ページ
20150618
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1259/bjr.20150618
出版者・発行元
BRITISH INST RADIOLOGY

Objective: To investigate the prognostic value of fluorine-18 fludeoxyglucose (FDG) positron emission tomography (PET) parameters for small-cell lung cancer (SCLC), according to the primary tumour location, adjusted by conventional prognostic factors.
Methods: From 2008 to 2013, we enrolled consecutive patients with histologically proven SCLC, who had undergone FDG-PET/CT prior to initial therapy. The primary tumour location was categorized into central or peripheral types. PET parameters and clinical variables were evaluated using univariate and multivariate analysis.
Results: A total of 69 patients were enrolled in this study; 28 of these patients were categorized as having the central type and 41 patients as having the peripheral type. In univariate analysis, stage, serum neuron-specific enolase, whole-body metabolic tumour volume (WB-MTV) and whole-body total lesion glycolysis (WB-TLG) were found to be significant in both types of patients. In multivariate analysis, the independent prognostic factor was found to be stage in the central type, but WB-MTV and WB-TLG in the peripheral type. Kaplan-Meier analysis demonstrated that patients with peripheral type with limited disease and low WB-MTV or WB-TLG showed significantly better overall survival than all of the other groups (p < 0.0083).
Conclusion: The FDG-PET volumetric parameters were demonstrated to be significant and independent prognostic factors in patients with peripheral type of SCLC, while stage was the only independent prognostic factor in patients with central type of SCLC.
Advances in knowledge: FDG-PET is a non-invasive method that could potentially be used to estimate the prognosis of patients, especially those with peripheral-type SCLC.

リンク情報
DOI
https://doi.org/10.1259/bjr.20150618
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26756811
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000372202900016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1259/bjr.20150618
  • ISSN : 0007-1285
  • eISSN : 1748-880X
  • PubMed ID : 26756811
  • Web of Science ID : WOS:000372202900016

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