Syunji Horie

Profile Information

Affiliation: Associate Professor, Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy, Laboratory of Chemical Pharmacology, Josai International University

Degree: Ph.D(Chiba University)

J-GLOBAL ID: 200901009245557057
researchmap Member ID: 1000010740

External link: http://www.p.chiba-u.ac.jp/lab/hinka/index.html

Research Interests

Research Areas

Research History

2002 - 2003

Ministry of Education,Culture,Sports,Science and Technology
2000 - 2001

Faculty of Pharmaceutical Sciences, Chiba University
2000 - 2001

Ministry of Education and Science,
2000 - 2001

Chiba University, Associate Professor
2001

- 千葉大学大学院薬学研究院助教授
2001

- Chiba University, Graduate School,
1997 - 2000

Faculty of Pharmaceutical Sciences, Chiba University
1997 - 2000

Chiba University, Lecturer
1988 - 1997

Faculty of Pharmaceutical Sciences, Chiba University
1988 - 1997

Chiba University, Research Associate
Visiting researcher in UK
Associate Professor

Education

Committee Memberships

1999

評議員, 和漢医薬学会
1999

評議員, 日本薬理学会
1999

councilor, Medical and Pharmaceutical Society of WAKAN-YAKU
1999

councilor, Japanese Pharmacological Society

Papers

Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats.

Noriyuki Ohashi, Kimihito Tashima, Takao Namiki, Syunji Horie

Journal of pharmacological sciences, 151(4) 187-194, Apr, 2023
Daikenchuto, a Traditional Kampo Medicine, Facilitates Mucosal Hyperemic Responses through Activation of TRPA1- and TRPV1-Expressing Sensory Nerves in Rat Stomach

Masatoshi Yoshikubo, Kimihito Tashima, Masaki Raimura, Yuto Watanabe, Yukiko Noma, Syunji Horie

Planta Medica International Open, 9(01) e72-e79, Jun, 2022
Allyl isothiocyanate-induced acute inflammation in the gastric mucosa leads to the impaired gastric motility in rodents: involvement of substance P and calcitonin gene-related peptide, but not mast cells

Tashima Kimihito, Oshige Marina, Fujii Yoko, Horie Syunji

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-P-053, 2022
The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia

Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie

Journal of Pharmacological Sciences, 145(1) 122-129, Jan, 2021
Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus.

Kenjiro Matsumoto, Hiroki Kawanaka, Masatoshi Hori, Kosuke Kusamori, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Syunji Horie, Akira Yamamoto, Hiroshi Ozaki …

American journal of physiology. Gastrointestinal and liver physiology, 315(1) G104-G116, Jul 1, 2018
[Gastrointestinal Spice Sensors and Their Functions].

Syunji Horie, Kimihito Tashima, Kenjiro Matsumoto

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 138(8) 1003-1009, 2018
Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity.

Kenjiro Matsumoto, Kanako Takagi, Atsumi Kato, Takuya Ishibashi, Yasuo Mori, Kimihito Tashima, Atsushi Mitsumoto, Shinichi Kato, Syunji Horie

Experimental neurology, 285(Pt A) 41-50, Nov, 2016
5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.

Daichi Utsumi, Kenjiro Matsumoto, Kikuko Amagase, Syunji Horie, Shinichi Kato

British journal of pharmacology, 173(11) 1835-49, Jun, 2016
Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.

Kenjiro Matsumoto, Hiroyuki Umemoto, Tomohisa Mori, Ryuya Akatsu, Shinichiro Saito, Kimihito Tashima, Masahiro Shibasaki, Shinichi Kato, Tsutomu Suzuki, Syunji Horie

European journal of pharmacology, 771 220-8, Jan 15, 2016
L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments.

Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, Horie S, Murayama T

Eur J Pharmacol, 764 471-479, Oct, 2015 Peer-reviewed
Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in post-operative ileus

Toko Maehara, Kenjiro Matsumoto, Kazuhide Horiguchi, Makoto Kondo, Satoshi Iino, Shunji Horie, Takahisa Murata, Hirokazu Tsubone, Shoichi Shimada, Hiroshi Ozaki …

British Journal of Pharmacology, 172(4) 1136-1147, 2015 Peer-reviewed
Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus

Kenjiro Matsumoto, Takuji Hosoya, Eriko Ishikawa, Kimihito Tashima, Kikuko Amagase, Shinichi Kato, Toshihiko Murayama, Syunji Horie

Histochemistry and Cell Biology, 142(6) 635-644, Nov 23, 2014 Peer-reviewed
Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation

H. Ono, A. Nakamura, K. Matsumoto, S. Horie, G. Sakaguchi, T. Kanemasa

Neurogastroenterology and Motility, 26(10) 1396-1407, Oct 1, 2014 Peer-reviewed
Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.

Hiroyasu Sakai, Atsunobu Sagara, Kenjiro Matsumoto, Ara Jo, Akiko Hirosaki, Kazuhide Takase, Ryoto Sugiyama, Ken Sato, Daigo Ikegami, Syunji Horie …

Pharmacological research, 87 71-9, Sep, 2014
TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice

T. Hosoya, K. Matsumoto, K. Tashima, H. Nakamura, H. Fujino, T. Murayama, S. Horie

Neurogastroenterol Motil, 26(8) 1112-1121, Aug, 2014 Peer-reviewed
覚醒下マウスにおける大建中湯の胃機能に対する薬理作用熱感受性TRPV1チャネルとの関連

奥見裕邦, 田嶋公人, 橋本和樹, 松本健次郎, 並木隆雄, 堀江俊治

和漢医薬学会学術大会要旨集, 31回 83-83, Aug, 2014
Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring lboga Derivatives

Yuko Terada, Mariko Kitajima, Fuyumi Taguchi, Hiromitsu Takayama, Syunji Horie, Tatsuo Watanabe

JOURNAL OF NATURAL PRODUCTS, 77(8) 1831-1838, Aug, 2014 Peer-reviewed
Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H …

The Journal of pharmacology and experimental therapeutics, 348(3) 383-392, Mar, 2014 Peer-reviewed
Activation and Inhibition of Thermosensitive TRP Channels by Voacangine, an Alkaloid Present in Voacanga africana, an African. Tree

Yuko Terada, Syunji Horie, Hiromitsu Takayama, Kunitoshi Uchida, Makoto Tominaga, Tatsuo Watanabe

JOURNAL OF NATURAL PRODUCTS, 77(2) 285-297, Feb, 2014 Peer-reviewed
Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.

Kenjiro Matsumoto, Tomoharu Nakajima, Hiroyasu Sakai, Sae Kato, Atsunobu Sagara, Kazuhiko Arakawa, Kimihito Tashima, Minoru Narita, Syunji Horie

Digestive diseases and sciences, 58(12) 3440-51, Dec, 2013

Misc.

161

センノシドA誘発慢性結腸通過遅延マウスモデルにおける結腸運動に対する大建中湯の改善作用

趙春暁, 田嶋公人, 並木隆雄, 堀江俊治

応用薬理, 100(5-6) 138-138, Aug, 2021
A NOVEL RAT MODEL OF HEARTBURN RESULTING FROM INCREASED THERMO-SENSITIVE TRPV1 AND TRPM8 CHANNELS-EXPRESSING SENSORY NERVES IN THE LOW ESOPHAGUS BASED ON GASTROESOPHAGEAL REFLUX DISEASE

Megumi Koide, Chisato Tachibana, Tomoharu Shinoki, Kimihito Tashima, Syunji Horie

GASTROENTEROLOGY, 158(6) S268-S269, May, 2020
ALLYL ISOTHIOCYANATE, AN ACTIVATOR OF TRPA1 CHANNEL, INCREASES GASTRIC MUCOSAL BLOOD FLOW THROUGH TRPV1-EXPRESSING AND NON-EXPRESSING SENSORY NERVES IN RATS: INVOLVEMENT OF CALCITONIN GENE-RELATED PEPTIDE

Kimihito Tashima, Noriyuki Ohashi, Masatoshi Yoshikubo, Marina Oshige, Takao Namiki, Syunji Horie

GASTROENTEROLOGY, 158(6) S520-S520, May, 2020
消化管疾患に対する漢方薬のエビデンスの構築をめざして実験動物を用いた大建中湯による胃腸機能の改善作用温度感受性TRPA1とTRPV1チャネルの関与

田嶋公人, 吉久保匡甫, 内木蓮, 後藤友希, 島田博文, 大重茉里奈, 並木隆雄, 堀江俊治

日本消化管学会雑誌, 4(Suppl.) 163-163, Jan, 2020
摘出マウス結腸における大建中湯による平滑筋収縮作用 TRPチャネルとカルシトニン遺伝子関連ペプチド

田嶋公人, 後藤友希, 島田博文, 並木隆雄, 堀江俊治

和漢医薬学会学術大会要旨集, 36回 96-96, Aug, 2019
DAIKENCHUTO, A TRADITIONAL JAPANESE (KAMPO) MEDICINE, FACILITATES GASTROINTESTINAL MOTILITY IN ISOLATED MOUSE DISTAL COLONS: ROLE OF TRPA1 CHANNEL AND CALCITONIN GENE-RELATED PEPTIDE

Hiroyo Kitagawa, Yuki Goto, Megumi Koide, Wakana Uematsu, Masatoshi Yoshikubo, Kimihito Tashima, Syunji Horie

GASTROENTEROLOGY, 156(6) S539-S539, May, 2019
KAMPO FORMULA DAIKENCHUTO FACILITATES MUCOSAL HYPEREMIC RESPONSES THROUGH ACTIVATION OF TRPA1 CHANNEL-EXPRESSING NEURONS IN RATS

Masatoshi Yoshikubo, Ren Uchiki, Megumi Koide, Hiroyo Kitagawa, Wakana Uematsu, Kimihito Tashima, Syunji Horie

GASTROENTEROLOGY, 156(6) S540-S540, May, 2019
摘出マウス遠位結腸標本における漢方薬大建中湯の平滑筋収縮作用ワサビ受容体TRPA1の関与

後藤友希, 田嶋公人, 島田博文, 並木隆雄, 堀江俊治

応用薬理, 92(5-6) 166-166, Aug, 2017
ALLYL ISOTHIOCYANATE, A PUNGENT INGREDIENT OF WASABI, INDUCES GASTRIC LOW-GRADE INFLAMMATION IN RATS TO LEAD TO THE IMPAIRED GASTRIC MOTILITY; INVOLVEMENT OF PROSTAGLANDIN, CAPSAICIN-SENSITIVE SENSORY NEURONS, AND NITRIC OXIDE

Kimihito Tashima, Shizuki Yamaura, Kazuki Hashimoto, Yasuhiro Mori, Tomoharu Shinoki, Yuki Ishihara, Syunji Horie

GASTROENTEROLOGY, 152(5) S563-S563, Apr, 2017
マウス摘出遠位結腸標本における大建中湯の平滑筋収縮作用ワサビ受容体TRPA1の関与

島田博文, 田嶋公人, 浦羽哲平, 野間裕紀子, 並木隆雄, 堀江俊治

和漢医薬学会学術大会要旨集, 33回 70-70, Aug, 2016
Contractile Effect of TRPA1 Activation With Allyl-Isothiocyanate in Isolated Mouse Distal Colon: Role of TRPA1-Expressing Neurons and Endogenous Prostaglandins

Kimihito Tashima, Hirobumi Shimada, Yukiko Noma, Teppei Uraba, Noriyuki Oshi, Takao Namiki, Syunji Horie

GASTROENTEROLOGY, 150(4) S520-S521, Apr, 2016
Protective Role of TRPA1 on TRPV1-Expessing Nerve Fibers Against Gastric Mucosal Barrier Break Induced by Allyl-isothiocyanate in Rats

Syunji Horie, Kimihito Tashima

DIGESTIVE DISEASES AND SCIENCES, 60(9) 2561-2562, Sep, 2015
A Rodent Model of Impaired Gastric Motility Resulting From Gastric Low-Grade Inflammation Induced by Allyl Isothiocyanate, a Pungent Ingredient of Wasabi, to Evaluate Therapeutic Agents for Functional Dyspepsia

Kimihito Tashima, Kenjiro Matsumoto, Kazuki Hashimoto, Taku Imai, Syunji Horie

GASTROENTEROLOGY, 148(4) S893-S894, Apr, 2015
Transient receptor potential cation channels in visceral pain

Kenjiro Matsumoto, Shinichi Kato, Syunji Horie

Folia Pharmacologica Japonica, 146(4) 233-235, 2015
Voacanga africana由来アルカロイドvoacangineの温度感受性TRPチャネルに対する活性・阻害作用

寺田祐子, 堀江俊治, 北島満里子

食品加工技術 : 日本食品機械研究会誌, 35(2) 49-60, 2015
Role of Transient Receptor Potential Melastatin 2 (TRPM2) Channels in Visceral Pain and Hypersensitivity in Rats

Kenjiro Matsumoto, Kimihito Tashima, Shinichi Kato, Syunji Horie

GASTROENTEROLOGY, 146(5) S156-S157, May, 2014
ALLYL ISOTHIOCYANATE, A PUNGENT INGREDIENT OF WASABI, INCREASES VASCULAR PERMEABILITY IN ANESTHETIZED RAT STOMACHS : ROLE OF TRASIENT RECEPTOR POTENTIAL ANKYRIN 1 CHANNEL

TASHIMA Kimihito, TAKEUCHI Tetsuya, MATSUMOTO Kenjiro, HORIE Syunji

40(1) 13-16, May 20, 2013
Distribution of Transient Receptor Potential Melastatin 2 Channels-Expressing Nerve Fibers in Rat Alimentary Tract and Dorsal Root Ganglion

Kenjiro Matsumoto, Tomoaki Watanabe, Minami Isohata, Kimihito Tashima, Syunji Horie

GASTROENTEROLOGY, 144(5) S369-S369, May, 2013
5-Fluorouracil Induces Diarrhea, Nausea, and Vomiting With Alteration of Aquaporin, Serotonin, and Neurokinin Receptors in Mice Intestine

Kenjiro Matsumoto, Junpei Odagiri, Kimihito Tashima, Syunji Horie

GASTROENTEROLOGY, 144(5) S718-S718, May, 2013
Japanese 'Kampo' Formula Daikenchuto, in Comparison With Its Similar Formula Ninjinto, Inhibits Gastric Acid Secretion Through Activation of Transient Receptor Potential Vanilloid Receptor Type 1 (TRPV1) Channels in Conscious Mice

Hirokuni Okumi, Kimihito Tashima, Kenjiro Matsumoto, Syunji Horie

GASTROENTEROLOGY, 144(5) S742-S742, May, 2013

Books and Other Publications

ファーマシューティカルノート

医学評論社, 2003
Introduction-The genus Magnolia（jointly worked）

Medicinal and Aromatic Plants volume 28, Magnolia, Taylor & Francis, 2002
胃酸関連疾患の病態と治療(共著)

医学書院, 2000
Acid related diseases

2000
幽門洞潰瘍に対するカプサイシン感受性知覚神経の役割(共著)

胃粘膜防御機構におけるカプサイシン感受性知覚神経の役割(医薬ジャーナル社), 1999
消化器系の運動および分泌機能に作用する薬物

医療薬学(]G0001[)医療薬学総論・医薬品の有効性と安全性廣川書店, 1999
消化器疾患と薬物治療(共著)

医療薬学III:疾病と薬物治療廣川書店, 1999
Roles of capsaicin-sensitive sensory neurons in gastric antral ulcers

1999
Pharmacological properties of some structurally related indole alkaloids contained in the Asian herbal medicines, hirsutine and mitragynine, with special reference to their Ca antagonistic and opioid-like effects. (jointly worked)

Pharmacological Research on Traditional Herbal Medicine, Harwood academic, 1999
Bioactive diterpenoids from a tropical herb, Scoparia dulcisL. (jointly worked)

Towards Natural Medicine Research in the 21 Century, Elsevier Science, 1998
Neuronal Ca²⁺ channel blocking and opioid receptor stimulating effects of mitragynine, an alkaloid of Thai herbal medicine kratom (Mitragyna speciosa) with opioid-like effects(jointly worked)

Current Advances in Natural Product Research, 1996
Antihypertensive properties of indole alkaloids including hirsutine and dihydrocorynantheine isolated from Uncaria plants(jointly worked)

Advance in research on pharmacologically active substances from natural sources, 1995
Pharmacological Profiles of 'kratom' (Mitragyna speciosa), a Thai Medical Plant, with special reference to its analgesic activity(jointly worked)

Advance in research on pharmacologically active substances from natural sources, 1995

Professional Memberships

Works

Research Projects

Involvement of neuroimmune in TRP channel-related gut hyperreactivity in animal models of functional gastrointestinal diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Mechanisms for increase of TRP channels in visceral hypersensitivity in inflammatory and functional bowel disease model animals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

HORIE SYUNJI
Role of thermo-sensitive TRPV1 and TRPM8 channels in visceral hypersensitivity in inflammatory bowel disease model animals and ulcerative colitis patients

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Horie Syunji, HOSOYA Takuji, YAMAKAWA Takumi
Studies on the synthesis of SPECT probe to elucidate the in vivo dynamics of natural opioids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

TAKAYAMA Hiromitsu, HORIE SHUNJI
Role of thermo-sensitive TRP channels in stress-induced visceral hyperesthesia: analyses of samples from disease model animals and patients

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

HORIE SYUNJI
Studies on isolation, total synthesis and medicinal chemistryof natural products with regulating activities on memory and pain.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

TAKAYAMA Hiromitsu, KOGURE Noriyuki, HORIE Shunji
Hyperreactivity of thermo-sensitive TRP channel-expressing sensory neurons under stress conditions, and effects of herbal medicines on hyperesthesia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

HORIE Syunji
Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

TAKAYAMA Hiromitsu, HORIE Shunji, KITAJIMA Mariko, KOGURE Noriyuki
Hyperesthesia via the alteration of thermo-sensitive TRP channels in animal model of irritable bowel syndrome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

HORIE Syunji
オピオイド受容体サブタイプを分子標的とする機能性コリナンテ型アルカロイドの開発

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

高山廣光, 堀江俊治, 北島満里子, 小暮紀行
Involvement of Hot and Cold Receptors in Stress-Induced Disorder of Gastrointestinal Tract

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

HORIE Shunji
モルヒネを超える新規オピオイド性鎮痛アルカロイドの探索と創製

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

高山廣光, 堀江俊治, 北島満里子
ストレス性胃腸運動障害にからむ新規神経ペプチド・ウロテンシンIIの知覚神経刺激

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2004 - 2005

村山俊彦, 平林哲也, 堀江俊治
Function and distribution of vanilloid receptor TRPVlas non-selective cation channels

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

HARIE Syunji
Development of New Type of Potent Opioid Agonists and the Molecular Mechanism for Exhibiting their Analgesic Activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2004

TAKAYAMA Hiromitsu, MURAYAMA Toshihiko, HORIE Shunji
非興奮性細胞における非選択的カチオンチャネルとしてのバニロイド受容体の機能的役割

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2001 - 2002

堀江俊治
Cellular and pharmacological studies for protection ofneuronal and endothelial cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2002

MURAYAMA Toshihiko, HIRABAYASHI Tetsuya, HORIE Shunji
分泌細胞の生体機能における容裏性カルシウム流入と非選択的カチオンチャネルの役割

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1999 - 2000

堀江俊治
Studies on the development of new opioid agonist by utilizing Mitragyna alkaloids as the lead-compounds

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

TAKAYAMA Hiromitsu, HORIE Shunji, WATANABE Kazuo, AIMI Norio
カルシウム拮抗薬抵抗性カルシウム流入を介する生体反応の解析とその遮断薬の薬理作用

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1997 - 1998

堀江俊治

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