堀内新一郎 (shinichiro horiuchi) - マイポータル

基本情報

所属: 厚生労働省　国立医薬品食品衛生研究所薬理部研究助手

学位: 博士（理学）(2004年3月東京工業大学)

研究者番号: 60588234
J-GLOBAL ID: 202401008158716328
researchmap会員ID: R000075389

受賞

論文

Stable and functional human intestinal epithelium derived from induced pluripotent stem cells

Junlong Chen, So Kuramochi, Shinichiro Horiuchi, Tomoyuki Kawasaki, Hiroto Kakizaki, Lilika Tabata, Tohru Kimura, Kazuaki Nakamura, Hidenori Akutsu, Seiichi Ishida …

Drug Metabolism and Disposition 100170-100170 2025年9月査読有り
Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory study

Hiroko Toyoda, Ayaka Nozue, Yuki Nishida, Yasuko Yakabe, Yasuhiko Aiki, Yukiko Ueyama-Toba, Kazuo Takayama, Hiroyuki Mizuguchi, Chihiro Mori, Yu-suke Torisawa …

European Journal of Cell Biology 104(3) 151497-151497 2025年9月査読有り
Human pluripotent stem cell-derived intestinal epithelial cells maintain small intestine-specific functions over time, even with repeated cell division

Junlong Chen, So Kuramochi, Shinichiro Horiuchi, Tomoyuki Kawasaki, Hiroto Kakizaki, Lirika Tabata, Tohru Kimura, Kazuaki Nakamura, Hidenori Akutsu, Seiichi Ishida …

2025年2月17日
Evaluation of Cell Culture Inserts in Drug Permeation Studies using Caco-2 Cells

Takashi Obara, Shinichiro Horiuchi, Daiju Yamazak

Alternatives to Animal Testing and Experimentation 30(1) 22-31 2025年査読有り
Examination of common culture medium for human hepatocytes and engineered heart tissue: Towards an evaluation of cardiotoxicity associated with hepatic drug metabolism in vitro

Shinichiro Horiuchi, Nanae Koda, Yui Ikeda, Yuto Tanaka, Yusuke Masuo, Yukio Kato, Daiju Yamazaki

PLOS ONE 19(12) e0315997-e0315997 2024年12月23日査読有り筆頭著者
Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture medium

Shinichiro Horiuchi, Yukie Kuroda, Ryota Oyafuso, Yuji Komizu, Kazuya Maeda, Seiichi Ishida

Archives of Toxicology 98(8) 2605-2617 2024年5月16日査読有り筆頭著者
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

JunLong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono …

Stem Cell Research & Therapy 15(1) 2024年1月17日査読有り
Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compounds

Takashi Kitaguchi, Shinichiro Horiuchi, Yukie Kuroda, Katsutoshi Ohno, Kazuhiro Kobayashi, Mitsuru Tanaka, Seiichi Ishida

The Journal of Toxicological Sciences 48(5) 251-261 2023年査読有り
Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics

Shinichiro Horiuchi, Yukie Kuroda, Yuji Komizu, Seiichi Ishida

Pharmaceutics 15(1) 55-55 2022年12月24日査読有り筆頭著者
Construction of a culture protocol for functional bile canaliculi formation to apply human iPS cell-derived hepatocytes for cholestasis evaluation

Shinichiro Horiuchi, Yukie Kuroda, Ryota Oyafuso, Yuji Komizu, Takashi Takaki, Kazuya Maeda, Seiichi Ishida

Scientific Reports 12(1) 2022年9月7日査読有り筆頭著者
Evaluation of Liver Fibrosis Induction and Inhibition using Human Cultured Hepatic Stellate Cell Spheroid

Kuroda, Yukie, Shinichiro Horiuchi, Satoha Aihoshi, Seiichi Ishida

Alternatives to Animal Testing and Experimentation 27(2) 41.-52 2022年査読有り
Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing

Manami Nishiwaki, Masashi Toyoda, Yoshie Oishi, Seiichi Ishida, Shinichiro Horiuchi, Hatsune Makino-Itou, Tohru Kimura, Shin-ichi Ohno, Takashi Ohkura, Shin Enosawa …

Scientific Reports 10(1) 2020年10月15日査読有り
Deactivation of Hepatic Stellate Cells by Culturing on VECELL Inserts

Shinichiro Horiuchi, Yukie Kuroda, Ryuya Fujii, Su-ryang Kim, Seiichi Ishida

Alternatives to Animal Testing and Experimentation 23(2) 53-62 2018年査読有り筆頭著者
Upregulations of metallothionein gene expressions and tolerance to heavy metal toxicity by three dimensional cultivation of HepG2 cells on VECELL 3-D inserts

Takashi Kubo, Yukie Kuroda, Shinichiro Horiuchi, Su-Ryang Kim, Yuko Sekino, Seiichi Ishida

The Journal of Toxicological Sciences 41(1) 147-153 2016年査読有り
Maintenance of hepatic progenitor-like characteristics of HepaRG cells by cultivation on VECELL Inserts

Kubo Takashi, Yukie Kuroda, Maki Hojyo, Su-ryang Kim, Shinichiro Horiuchi, Yuko Sekino, Fabrice Morel, Anne Corlu, Seiichi Ishida

Alternatives to Animal Testing and Experimentation 21(2) 71-79 2016年査読有り
Global gene expression changes including drug metabolism and disposition induced by three-dimensional culture of HepG2 cells-Involvement of microtubules

Shinichiro Horiuchi, Seiichi Ishida, Tomokatsu Hongo, Youichi Ishikawa, Atsuko Miyajima, Jun-ichi Sawada, Yasuo Ohno, Ken Nakazawa, Shogo Ozawa

Biochemical and Biophysical Research Communications 378(3) 558-562 2009年1月査読有り筆頭著者
Change in broth culture is associated with significant suppression of Escherichia coli death under high magnetic field

Shinichiro Horiuchi, Yoshimasa Ishizaki, Kazumasa Okuno, Takashi Ano, Makoto Shoda

Bioelectrochemistry 57(2) 139-144 2002年9月査読有り筆頭著者
Twelve hours exposure to inhomogeneous high magnetic field after logarithmic growth phase is sufficient for drastic suppression of Escherichia coli death

Yoshimasa Ishizaki, Shin-ichiro Horiuchi, Kazumasa Okuno, Takashi Ano, Makoto Shoda

Bioelectrochemistry 54(2) 101-105 2001年11月査読有り
Drastic high magnetic field effect on suppression of Escherichia coli death

Shin-ichiro Horiuchi, Yoshimasa Ishizaki, Kazumasa Okuno, Takashi Ano, Makoto Shoda

Bioelectrochemistry 53(2) 149-153 2001年3月査読有り筆頭著者

共同研究・競争的資金等の研究課題

ヌードマウスに発毛を誘導する因子の同定

日本学術振興会科学研究費助成事業挑戦的萌芽研究 2013年4月 - 2016年3月

堀内新一郎, 久保田俊一郎
細胞の死滅が高磁場によって抑制されるメカニズムの解明

財団法人磁気健康科学研究振興財団研究助成金 2000年3月 - 2001年4月

堀内新一郎

堀内新一郎

基本情報

受賞

論文

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧