武内恒成 (Kosei Takeuchi) - マイポータル

基本情報

所属: 愛知医科大学医学部教授
: 新潟大学医学部客員教授
: 広島大学客員教授

学位: 博士（医学）
博士（学術）

ORCID ID: https://orcid.org/0000-0001-6397-2243
J-GLOBAL ID: 200901056963777586
researchmap会員ID: 1000320705

外部リンク: https://www.take-lab.org

研究キーワード

研究分野

経歴

2019年 - 現在

愛知医科大学研究創出センターセンター長(兼務）
2014年1月 - 現在

愛知医科大学医学部教授（大学院細胞生物学教授）
2008年 - 2013年12月

新潟大学医学部生化学第二准教授
2006年 - 2008年

京都府立医科大学大学院医学研究科解剖学講師～
2004年 - 2006年

兼：エーザイ(株)KAN研究所グループリーダー
2000年 - 2004年

名古屋大学大学院超分子システム学講師講師
1996年 - 2000年

奈良先端科学技術大学院大学バイオサイエンス研究科助教
1998年

ペンシルバニア大学医学部日本学術振興会海外特別研究員
1994年 - 1996年

東京都老人医療センター研究所主事研究員
1988年 - 1990年

文科省放射線医学総合研究所薬理化学部研究員

委員歴

論文

Bone marrow derived mast cells injected into the osteoarthritic knee joints of mice induced by sodium monoiodoacetate enhanced spontaneous pain through activation of PAR2 and action of extracellular ATP.

Hiroko Habuchi, Masashi Izumi, Junpei Dan, Takahiro Ushida, Masahiko Ikeuchi, Kosei Takeuchi

PloS one 16(6) e0252590 2021年査読有り最終著者
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.

Kunimichi Suzuki, Jonathan Elegheert, Inseon Song, Hiroyuki Sasakura, Oleg Senkov, Keiko Matsuda, Wataru Kakegawa, Amber J Clayton, Veronica T Chang, Maura Ferrer-Ferrer, Eriko Miura, Rahul Kaushik, Masashi Ikeno, Yuki Morioka, Yuka Takeuchi, Tatsuya Shimada, Shintaro Otsuka, Stoyan Stoyanov, Masahiko Watanabe, Kosei Takeuchi, A Radu Aricescu, Michisuke Yuzaki

Science (New York, N.Y.) 369(6507) 2020年8月28日査読有り
Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.

Rino Inada, Katsuichi Miyamoto, Noriko Tanaka, Kota Moriguchi, Kenji Kadomatsu, Kosei Takeuchi, Susumu Kusunoki

Glycobiology 31(3) 260-265 2020年7月28日査読有り
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

Keiko Nakanishi, Hiroyuki Niida, Hidenori Tabata, Tsuyoshi Ito, Yuki Hori, Madoka Hattori, Yoshikazu Johmura, Chisato Yamada, Takashi Ueda, Kosei Takeuchi, Kenichiro Yamada, Koh-Ichi Nagata, Nobuaki Wakamatsu, Masashi Kishi, Y Albert Pan, Shinya Ugawa, Shoichi Shimada, Joshua R Sanes, Yujiro Higashi, Makoto Nakanishi

Cerebral cortex (New York, N.Y. : 1991) 29(9) 3738-3751 2019年8月14日査読有り
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.

Hiroko Ida-Yonemochi, Wataru Morita, Nobuo Sugiura, Ryosuke Kawakami, Yuki Morioka, Yuka Takeuchi, Toshiya Sato, Shunichi Shibata, Hideto Watanabe, Takeshi Imamura, Michihiro Igarashi, Hayato Ohshima, Kosei Takeuchi

Scientific reports 8(1) 17134-17134 2018年11月20日査読有り
Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity.

Michihiro Igarashi, Kosei Takeuchi, Sayaka Sugiyama

Neurochemistry international 119 77-83 2018年10月査読有り
Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment.

Jun Yamada, Satomi Nadanaka, Hiroshi Kitagawa, Kosei Takeuchi, Shozo Jinno

The Journal of neuroscience : the official journal of the Society for Neuroscience 38(39) 8496-8513 2018年9月26日査読有り
Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration.

Asami Kawasaki, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi

iScience 4 190-203 2018年6月29日査読有り
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.

Nozomu Yoshioka, Shinji Miyata, Atsushi Tamada, Yumi Watanabe, Asami Kawasaki, Hiroshi Kitagawa, Keizo Takao, Tsuyoshi Miyakawa, Kosei Takeuchi, Michihiro Igarashi

Molecular brain 10(1) 47-47 2017年10月5日査読有り
Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.

Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K Hensch, Katsuei Shibuki, Michihiro Igarashi, Sayaka Sugiyama

Scientific reports 7(1) 12646-12646 2017年10月3日査読有り
Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans.

Hiroyuki Sasakura, Hiroki Moribe, Masahiko Nakano, Kazuto Ikemoto, Kosei Takeuchi, Ikue Mori

Journal of cell science 130(15) 2631-2643 2017年8月1日査読有り
Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules.

Atsuko Honda, Yasuyuki Ito, Kazuko Takahashi-Niki, Natsuki Matsushita, Motohiro Nozumi, Hidenori Tabata, Kosei Takeuchi, Michihiro Igarashi

The Journal of neuroscience : the official journal of the Society for Neuroscience 37(15) 4046-4064 2017年4月12日査読有り
Claudin-21 Has a Paracellular Channel Role at Tight Junctions.

Hiroo Tanaka, Yasuko Yamamoto, Hiroka Kashihara, Yuji Yamazaki, Kazutoshi Tani, Yoshinori Fujiyoshi, Katsuhiko Mineta, Kosei Takeuchi, Atsushi Tamura, Sachiko Tsukita

Molecular and cellular biology 36(6) 954-64 2016年1月4日査読有り
A newly identified mouse hypothalamic area having bidirectional neural connections with the lateral septum: the perifornical area of the anterior hypothalamus rich in chondroitin sulfate proteoglycans.

Noriko Horii-Hayashi, Takayo Sasagawa, Takashi Hashimoto, Takeshi Kaneko, Kosei Takeuchi, Mayumi Nishi

The European journal of neuroscience 42(6) 2322-34 2015年9月査読有り
The role of T-cadherin in axonal pathway formation in neocortical circuits.

Yuki Hayano, Hong Zhao, Hiroaki Kobayashi, Kosei Takeuchi, Shigemi Norioka, Nobuhiko Yamamoto

Development (Cambridge, England) 141(24) 4784-93 2014年12月査読有り
Pioneering axons regulate neuronal polarization in the developing cerebral cortex.

Takashi Namba, Yuji Kibe, Yasuhiro Funahashi, Shinichi Nakamuta, Tetsuya Takano, Takuji Ueno, Akiko Shimada, Sachi Kozawa, Mayumi Okamoto, Yasushi Shimoda, Kanako Oda, Yoshino Wada, Tomoyuki Masuda, Akira Sakakibara, Michihiro Igarashi, Takaki Miyata, Catherine Faivre-Sarrailh, Kosei Takeuchi, Kozo Kaibuchi

Neuron 81(4) 814-29 2014年2月19日査読有り
Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.

Yumi Watanabe, Norikazu Katayama, Kosei Takeuchi, Tetsuya Togano, Rieko Itoh, Michiko Sato, Maya Yamazaki, Manabu Abe, Toshiya Sato, Kanako Oda, Minesuke Yokoyama, Keizo Takao, Masahiro Fukaya, Tsuyoshi Miyakawa, Masahiko Watanabe, Kenji Sakimura, Toshiya Manabe, Michihiro Igarashi

The Journal of biological chemistry 288(48) 34906-19 2013年11月29日査読有り
TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.

Mayumi Okamoto, Takashi Namba, Tomoyasu Shinoda, Takefumi Kondo, Tadashi Watanabe, Yasuhiro Inoue, Kosei Takeuchi, Yukiko Enomoto, Kumiko Ota, Kanako Oda, Yoshino Wada, Ken Sagou, Kanako Saito, Akira Sakakibara, Ayano Kawaguchi, Kazunori Nakajima, Taiji Adachi, Toshihiko Fujimori, Masahiro Ueda, Shigeo Hayashi, Kozo Kaibuchi, Takaki Miyata

Nature neuroscience 16(11) 1556-66 2013年11月査読有り
Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.

Kosei Takeuchi, Nozomu Yoshioka, Susumu Higa Onaga, Yumi Watanabe, Shinji Miyata, Yoshino Wada, Chika Kudo, Masayasu Okada, Kentaro Ohko, Kanako Oda, Toshiya Sato, Minesuke Yokoyama, Natsuki Matsushita, Masaya Nakamura, Hideyuki Okano, Kenji Sakimura, Hitoshi Kawano, Hiroshi Kitagawa, Michihiro Igarashi

Nature communications 4 2740-2740 2013年査読有り
Development of the dorsal ramus of the spinal nerve in the chick embryo: a close relationship between development and expression of guidance cues.

Tomoyuki Masuda, Chie Sakuma, Masahiko Taniguchi, Ayae Kanemoto, Madoka Yoshizawa, Kaishi Satomi, Hideaki Tanaka, Kosei Takeuchi, Shuichi Ueda, Hiroyuki Yaginuma, Takashi Shiga

Brain research 1480 30-40 2012年10月22日査読有り