2010年4月
Aberrant REST-mediated transcriptional regulation in major depressive disorder
JOURNAL OF PSYCHIATRIC RESEARCH
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- 巻
- 44
- 号
- 6
- 開始ページ
- 378
- 終了ページ
- 384
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jpsychires.2009.09.009
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
There is growing evidence that aberrant transcriptional regulation is one of the key components of the pathophysiology of mood disorders. The repressor element-1 silencing transcription factor (REST) is a negative regulator of genes that contain the repressor element-1 (RE-1) binding site. REST has many target genes, including corticotropin releasing hormone (CRH), brain-derived neurotrophic factor, serotonin 1A receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants. However, a potential role for REST-mediated transcriptional regulation in mood disorders remains unclear. In this study, we examined the mRNA levels of REST and its known and putative target genes, using quantitative real-time PCR in peripheral blood cells of patients with major depressive and bipolar disorders in both a current depressive and a remissive state. We found reduced mRNA expression of REST and increased mRNA expression of CRH, adenylate cyclase 5, and the tumor necrosis factor superfamily, member 12-13 in patients with major depressive disorder in a current depressive state, but not in a remissive state. Altered expression of these mRNAs was not found in patients with bipolar disorder. Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression. (C) 2009 Elsevier Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.jpsychires.2009.09.009
- CiNii Articles
- http://ci.nii.ac.jp/naid/10029785570
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19846118
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000277820300006&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.jpsychires.2009.09.009
- ISSN : 0022-3956
- CiNii Articles ID : 10029785570
- PubMed ID : 19846118
- Web of Science ID : WOS:000277820300006