2004年6月
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
CANCER RESEARCH
- 巻
- 64
- 号
- 11
- 開始ページ
- 3753
- 終了ページ
- 3756
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1158/0008-5472.CAN-04-0637
- 出版者・発行元
- AMER ASSOC CANCER RESEARCH
In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.
- リンク情報
- ID情報
-
- DOI : 10.1158/0008-5472.CAN-04-0637
- ISSN : 0008-5472
- PubMed ID : 15172979
- Web of Science ID : WOS:000221727300006