2020年
Lecithin-based dermal drug delivery for anti-pigmentation maize ceramide
Molecules
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- 巻
- 25
- 号
- 7
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/molecules25071595
Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use.
- リンク情報
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- DOI
- https://doi.org/10.3390/molecules25071595
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/32244349
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180834
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85082793396&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85082793396&origin=inward
- ID情報
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- DOI : 10.3390/molecules25071595
- eISSN : 1420-3049
- PubMed ID : 32244349
- PubMed Central 記事ID : PMC7180834
- SCOPUS ID : 85082793396