2001年10月
Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
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- 巻
- 47
- 号
- 5
- 開始ページ
- 340
- 終了ページ
- 344
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3177/jnsv.47.340
- 出版者・発行元
- CENTER ACADEMIC PUBL JAPAN
The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) reduced the blood glucose of KK-Ay mice 3 weeks after oral administration (p<0.01) and also significantly lowered the serum insulin of KK-Ay mice under similar conditions (p<0.01). However. MC did not affect the blood glucose in normal mice. MC-treated KK-Ay mice blood glucose significantly decreased in an insulin tolerance test. Moreover, the muscle content of facilitative glucose transporter isoform 4 (GLUT4) protein content in the plasma membrane fraction from muscle significantly increased in the orally MC-treated mice when compared with that of the controls (p<0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from a decrease in insulin resistance because of the increase of GLUT4 protein content in the plasma membrane of the muscle.
- リンク情報
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- DOI
- https://doi.org/10.3177/jnsv.47.340
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902127361602422
- CiNii Articles
- http://ci.nii.ac.jp/naid/10008015680
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/11814149
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000172430800004&DestApp=WOS_CPL
- ID情報
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- DOI : 10.3177/jnsv.47.340
- ISSN : 0301-4800
- J-Global ID : 200902127361602422
- CiNii Articles ID : 10008015680
- PubMed ID : 11814149
- Web of Science ID : WOS:000172430800004