論文

査読有り 国際誌
2020年2月3日

The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.

EMBO reports
  • Natsune Takagaki
  • ,
  • Akane Ohta
  • ,
  • Kohei Ohnishi
  • ,
  • Akira Kawanabe
  • ,
  • Yohei Minakuchi
  • ,
  • Atsushi Toyoda
  • ,
  • Yuichiro Fujiwara
  • ,
  • Atsushi Kuhara

21
3
開始ページ
e48671
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.15252/embr.201948671

Caenorhabditis elegans mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by mechanoreceptor-mediated circuit calculation.

リンク情報
DOI
https://doi.org/10.15252/embr.201948671
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32009302
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054665
ID情報
  • DOI : 10.15252/embr.201948671
  • PubMed ID : 32009302
  • PubMed Central 記事ID : PMC7054665

エクスポート
BibTeX RIS