Akira Kawanabe

Profile Information

Affiliation: Lecturer, Faculty of Medicine, Kagawa University

Degree: 博士(工学)(名古屋工業大学)

J-GLOBAL ID: 201301059428453862
researchmap Member ID: B000229295

Research Interests

Research Areas

Research History

Jun, 2019 - Present

Faculty of Medicine, Kagawa University
Mar, 2015 - May, 2019

特任助教, 医学系研究科, 大阪大学大学院
Apr, 2013 - Feb, 2015

特任研究員, 医学系研究科, 大阪大学大学院
Apr, 2010 - Mar, 2013

日本学術振興会特別研究員PD, 医学系研究科, 大阪大学大学院
Apr, 2007 - Mar, 2010

Graduate School of Engineering, Nagoya Institute of Technology

Education

Apr, 2005 - Mar, 2009

Graduate School of Engineering, Nagoya Institute of Technology
Apr, 2001 - Mar, 2005

Faculty of Engineering, Nagoya Institute of Technology

Committee Memberships

Apr, 2019 - Present

評議員, 日本生理学会
Jan, 2021 - Dec, 2021

分野別専門委員(電気生理学), 日本生物物理学会

Awards

Mar, 2019

第9回入澤宏・彩記念若手研究奨励賞, 日本生理学会

Papers

Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA.

Takunari Kiya, Kohei Takeshita, Akira Kawanabe, Yuichiro Fujiwara

The Journal of biological chemistry, 298(8) 102257-102257, Jul 12, 2022 Peer-reviewed
Interaction between S4 and the phosphatase domain mediates electrochemical coupling in voltage-sensing phosphatase (VSP).

Natsuki Mizutani, Akira Kawanabe, Yuka Jinno, Hirotaka Narita, Tomoko Yonezawa, Atsushi Nakagawa, Yasushi Okamura

Proceedings of the National Academy of Sciences of the United States of America, 119(26) e2200364119, Jun 28, 2022 Peer-reviewed
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels.

Andrey Rozenberg, Igor Kaczmarczyk, Donna Matzov, Johannes Vierock, Takashi Nagata, Masahiro Sugiura, Kota Katayama, Yuma Kawasaki, Masae Konno, Yujiro Nagasaka, Mako Aoyama, Ishita Das, Efrat Pahima, Jonathan Church, Suliman Adam, Veniamin A Borin, Ariel Chazan, Sandra Augustin, Jonas Wietek, Julien Dine, Yoav Peleg, Akira Kawanabe, Yuichiro Fujiwara, Ofer Yizhar, Mordechai Sheves, Igor Schapiro, Yuji Furutani, Hideki Kandori, Keiichi Inoue, Peter Hegemann, Oded Béjà, Moran Shalev-Benami

Nature structural & molecular biology, 29(6) 592-603, Jun, 2022 Peer-reviewed
Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels

Takafumi Kawai, Masaki Hashimoto, Natsuki Eguchi, Junko M. Nishino, Yuka Jinno, Risa Mori-Kreiner, Måns Aspåker, Daijiro Chiba, Yukio Ohtsuka, Akira Kawanabe, Atsuo S. Nishino, Yasushi Okamura

Journal of Biological Chemistry, 296 100783-100783, Jan, 2021 Peer-reviewed
Engineering an enhanced voltage-sensing phosphatase.

Akira Kawanabe, Natsuki Mizutani, Onur K Polat, Tomoko Yonezawa, Takafumi Kawai, Masayuki X Mori, Yasushi Okamura

The Journal of general physiology, 152(5), May 4, 2020 Peer-reviewed
The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.

Natsune Takagaki, Akane Ohta, Kohei Ohnishi, Akira Kawanabe, Yohei Minakuchi, Atsushi Toyoda, Yuichiro Fujiwara, Atsushi Kuhara

EMBO reports, 21(3) e48671, Feb 3, 2020 Peer-reviewed
Activation Mechanisms of Voltage Sensing Phosphatase

Akira KAWANABE, Kazuhisa NISHIZAWA, Yasushi OKAMURA

Seibutsu Butsuri, 60(2) 105-107, 2020 Peer-reviewed
Functional analysis of a double-point mutation in the KCNJ2 gene identified in a family with Andersen-Tawil syndrome.

Shinobu Fukumura, Kosuke Yamauchi, Akira Kawanabe, Akiyo Yamamoto, Maki Nakaza, Tomoya Kubota, Shinsuke Kato, Ryogen Sasaki, Yasushi Okamura, Masanori P Takahashi

Journal of the neurological sciences, 407 116521-116521, Dec 15, 2019 Peer-reviewed
The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

Kawanabe A, Hashimoto M, Nishizawa M, Nishizawa K, Narita H, Yonezawa T, Jinno Y, Sakata S, Nakagawa A, Okamura Y

eLife, Nov, 2018 Peer-reviewed
Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering.

Okamura Y, Kawanabe A, Kawai T

Physiological Reviews., Oct, 2018 Peer-reviewedInvited
Domain-to-domain coupling in voltage-sensing phosphatase.

Souhei Sakata, Makoto Matsuda, Akira Kawanabe, Yasushi Okamura

Biophysics and physicobiology, 14 85-97, Jun, 2017 Peer-reviewedInvited
Comparison between mouse and sea urchin orthologs of voltage-gated proton channel suggests role of S3 segment in activation gating

Souhei Sakata, Nana Miyawaki, Thomas J. McCormack, Hiroki Arima, Akira Kawanabe, Nurdan Oezkucur, Tatsuki Kurokawa, Yuka Jinno, Yuichiro Fujiwara, Yasushi Okamura

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1858(12) 2972-2983, Dec, 2016 Peer-reviewed
Erratum: Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid (Proceedings of the National Academy of Sciences of the United States of America (2016) 113:27 (7521-7526) DOI: 10.1073/pnas.1604218113)

Souhei Sakata, Yuka Jinno, Akira Kawanabe, Yasushi Okamura

Proceedings of the National Academy of Sciences of the United States of America, 113(27) 7521-7526, Nov 29, 2016 Peer-reviewed
Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid

Sakata S, Jinno Y, Kawanabe A, Okamura Y

Proc. Natl. Acad. Sci. U. S. A., Jun, 2016 Peer-reviewed
Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells

Akira Kawanabe, Yasushi Okamura

JOURNAL OF PHYSIOLOGY-LONDON, 594(3) 595-610, Feb, 2016 Peer-reviewed
X-ray crystal structure of voltage-gated proton channel

Kohei Takeshita, Souhei Sakata, Eiki Yamashita, Yuichiro Fujiwara, Akira Kawanabe, Tatsuki Kurokawa, Yoshifumi Okochi, Makoto Matsuda, Hirotaka Narita, Yasushi Okamura, Atsushi Nakagawa

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 21(4) 352-U170, Apr, 2014 Peer-reviewed
Primary structural response in tryptophan residues of Anabaena sensory rhodopsin to photochromic reactions of the retinal chromophore

Inada Seisuke, Mizuno Misao, Kato Yoshitaka, Kawanabe Akira, Kandori Hideki, Wei Zhengrong, Takeuchi Satoshi, Tahara Tahei, Mizutani Yasuhisa

CHEMICAL PHYSICS, 419 65-73, Jun 20, 2013 Peer-reviewed
Comparative FTIR Study of a New Fungal Rhodopsin

Hiroyasu Ito, Masayo Sumii, Akira Kawanabe, Ying Fan, Yuji Furutani, Leonid S. Brown, Hideki Kandori

JOURNAL OF PHYSICAL CHEMISTRY B, 116(39) 11881-11889, Oct, 2012 Peer-reviewed
Diversity and functional analysis of proteorhodopsin in marine Flavobacteria

Susumu Yoshizawa, Akira Kawanabe, Hiroyasu Ito, Hideki Kandori, Kazuhiro Kogure

ENVIRONMENTAL MICROBIOLOGY, 14(5) 1240-1248, May, 2012 Peer-reviewed
Anomalous pH Effect of Blue Proteorhodopsin

Keisuke Yamada, Akira Kawanabe, Susumu Yoshizawa, Kentaro Inoue, Kazuhiro Kogure, Hideki Kandori

JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 3(7) 800-804, Apr, 2012 Peer-reviewed

Misc.

The voltage-gated proton channel is regulated by ATP

Mar, 2022 Lead author
イノシト－ルリン脂質により修飾されるKcsAの機能特性と分子基盤

紀谷拓音, 川鍋陽, 藤原祐一郎

第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会合同大会, Mar, 2021
Patch Clamp fluorometry によるVSP 細胞内構造変化解析に向けて

川鍋陽, 藤原祐一郎

第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会合同大会, Mar, 2021 Lead author
膜タンパク質の分子機構解析への非天然蛍光アミノ酸の活用

川鍋陽, 坂田宗平, 岡村康司

日本薬学会第141年会, Mar, 2021 InvitedLead author
イノシトールリン脂質によるKcsA の制御

紀谷拓音, 川鍋陽, 藤原祐一郎

第58回日本生物物理学会年会, Sep, 2020
電位依存性プロトンチャネルの細胞内側からの制御

川鍋陽, 藤原祐一郎

第58回日本生物物理学会年会, Sep, 2020 Lead author
遺伝学的検査により同定されたAndersen‐Tawil症候群家系における新規遺伝子変異V296Fとその機能解析

山内亨祐, 福村忍, 川鍋陽, 山本晃代, 仲座真希, 久保田智哉, 加藤辰輔, 佐々木良元, 岡村康司, 高橋正紀

臨床神経生理学(Web), 46(5) 482(J‐STAGE)-482, Oct, 2018
Roles of membrane interaction in electrochemical coupling in voltage-sensing phosphatase

Yasushi Okamura, Akira Kawanabe, Kazuhisa Nishizawa, Souhei Sakata

Cold Spring Harbor Conferences Asia, Suzhou Industrial Park, Conference Center, China, May, 2017
Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid (vol 113, pg 7521, 2016)

Souhei Sakata, Yuka Jinno, Akira Kawanabe, Yasushi Okamura

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(48) E7866-E7866, Nov, 2016
1P220 The electrophysiological recording of the reconstituted voltagegated proton channel in artificial membrane(13C. Biological & Artificial membrane: Excitation & Channels,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Kawanabe Akira, Okamura Yasushi

Seibutsu Butsuri, 54(1) S177, 2014
The Activation Kinetics of the Voltage-Gated Proton Channel is Drastically Accelerated by Unsaturated Fatty Acids

Akira Kawanabe, Yasushi Okamura

BIOPHYSICAL JOURNAL, 106(2) 744A-744A, Jan, 2014
Molecular mechanisms of voltage-gated proton channel, VSOP/Hv1

Okamura Y, Fujiwara Y, Kawanabe A, Sakata S, Kurokawa T

Journal of Physiological Sciences, 64(Supplement1) S84, 2014 Peer-reviewed
3P036 Study of Anabaena Sensory Rhodopsin mutant P206D that contains the 13-cis form dominantly(01A. Protein: Structure,Poster)

Kato Yoshitaka, Kawanabe Akira, Inoue Keiichi, Jung Kwang-Hwan, Kandori Hideki

Seibutsu Butsuri, 53(1) S217, 2013
2P219 Effects of the unsaturated fatty acids on the voltage-gated proton channel(13C. Biological & Artifical membrane: Excitation & Channels,Poster)

Kawanabe Akira, Okamura Yasushi

Seibutsu Butsuri, 53(1) S195, 2013
1F1510 Pro206 of Anabaena sensory rhodopsin is responsible for the isomeric composition of retinal and photochromism(Photobiology: Vision & Photoreception I,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

Kato Yoshitaka, Kawanabe Akira, Jung Kwang-Hwan, Kandori Hideki

Seibutsu Butsuri, 52 S30, 2012
電位依存性プロトンチャネルの構造と機能

岡村康司, 藤原祐一郎, 黒川竜紀, 坂田宗平, 川鍋陽, 大河内善史

日本生化学会大会プログラム・講演要旨集, 84回 1S10a-4, Sep, 2011
2Q1536 A Mutational Study of Anabaena Sensory Rhodopsin(Photobiology: Vision & Photoreception 2,The 48th Annual Meeting of the Biophysical Society of Japan)

Kato Yoshitaka, Kawanabe Akira, Kwang-Hwan Jung, Kandori Hideki

Seibutsu Butsuri, 51 S102-S103, 2011
2Q1524 In situ measurement of light-driven proton pump by proteorhodopsin of marine Flavobacteria(Photobiology: Vision & Photoreception 2,The 48th Annual Meeting of the Biophysical Society of Japan)

Ito Hiroyasu, Yoshizawa Susumu, Kawanabe Akira, Kogure Kazuhiro, Kandori Hideki

Seibutsu Butsuri, 51 S102, 2011
逆向きプロトン輸送タンパク質の創成

川鍋陽, 古谷祐詞, 神取秀樹

生物物理, 50 236-237, Oct, 2010
1P258 FTIR study of a new fungal rhodopsin(Photobiology:Vision & Photoreception,The 48th Annual Meeting of the Biophysical Society of Japan)

Ito Hiroyasu, Kawanabe Akira, Fan Ying, Brown Leonid S., Kandori Hideki

Seibutsu Butsuri, 50(2) S65, 2010

Presentations

The voltage-gated proton channel is regulated by ATP

Mar, 2022
カリウムチャネルとイノシトールリン脂質の分子間相互作用と機能修飾

紀谷拓音, 竹下浩平, 川鍋陽, 藤原祐一郎

生理研研究会「細胞の局所コミュニティ研究会」, Feb 24, 2022
膜タンパク質の分子機構解析への非天然蛍光アミノ酸の活用

川鍋陽, 坂田宗平, 岡村康司

日本薬学会第141年会, Mar, 2021 Invited
Patch Clamp fluorometry によるVSP 細胞内構造変化解析に向けて

川鍋陽, 藤原祐一郎

第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会合同大会, Mar, 2021
イノシト－ルリン脂質により修飾されるKcsAの機能特性と分子基盤

紀谷拓音, 川鍋陽, 藤原祐一郎

第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会合同大会, Mar, 2021
ホスフォイノシチドによるKcsAの機能制御

紀谷拓音, 川鍋陽, 藤原祐一郎

生理研研究会「イオンチャネルと生体膜のダイナミズム：構造生物学の先にあるもの」, Oct 6, 2020
電位依存性プロトンチャネル活性に影響する細胞内分子

川鍋陽, 藤原祐一郎

生理研研究会「イオンチャネルと生体膜のダイナミズム：構造生物学の先にあるもの」, Oct 6, 2020
電位依存性プロトンチャネルの細胞内側からの制御

川鍋陽, 藤原祐一郎

第58回日本生物物理学会年会, Sep, 2020
イノシトールリン脂質によるKcsA の制御

紀谷拓音, 川鍋陽, 藤原祐一郎

第58回日本生物物理学会年会, Sep, 2020
非天然蛍光アミノ酸を用いた膜タンパク質の動作メカニズム解析

川鍋陽, 米澤智子, 神野有香, 坂田宗平, 岡村康司

日本薬学会第140年会 Invited
The conformational change of the cytoplasmic region of voltage-sensing phosphatase

Akira Kawanabe, Manami Nishizawa, Kazuhisa Nishizawa, Hirotaka Narita, Tomoko Yonezawa, Yuka Jinno, Souhei Sakata, Atsushi Nakagawa, Yasushi Okamura

Invited

Professional Memberships

Research Projects

電気生理-蛍光変化同時計測系によるプロトンチャネルの制御機構解析

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

川鍋陽
硫化水素分子によるイオンチャネルの機能修飾機構の解明

科学研究費助成事業学術変革領域研究(A), 日本学術振興会, Jun, 2022 - Mar, 2024

川鍋陽
Development of light-driven neural devices

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2023
電気生理学と分光学の統合によるイノシトールリン脂質ホスファターゼの動作原理の解析

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

川鍋陽
The anlaysis of the cooperative gating of voltage-gated proton channel

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Kawanabe Akira
電位センサータンパク質の作用機序に対する物理化学的手法を用いた解析

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2010 - 2012

川鍋陽
赤外分光法によるロドプシンの情報伝達機構の解析

科学研究費助成事業特別研究員奨励費, 日本学術振興会, 2007 - 2009

川鍋陽

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