Nov, 2010
Role of Angiontensin Receptors on Remodeling Perivascular Nerves
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
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- Volume
- 130
- Number
- 11
- First page
- 1421
- Last page
- 1425
- Language
- Japanese
- Publishing type
- DOI
- 10.1248/yakushi.130.1421
- Publisher
- PHARMACEUTICAL SOC JAPAN
The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP) -containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. An age-related decrease in the density of CGRP-like immunoreactive (LI) -containing nerve fibers but not neuropeptide Y (NPY) -LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). The density of NPY-LI-containing nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin-converting enzyme inhibitor (0.005% temocapril), angiotensin 11 type-1 (AT1) receptor antagonist (0.025% losartan), or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured using the tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. Furthermore, to clarify the effect of the angiontensin II type-2 (AT2) receptor in the restoration of perivascular nerve innervation, we used the phenol-injured rat model, in which the perivascular nerves are markedly reduced by the topical application of phenol. Activation of AT2R significantly restored CGRP-LI innervation in phenol-injured rats. These results suggest that selective stimulation of AT2 receptors facilitates reinnervation of mesenteric perivascular CGRP-containing nerves.
- Link information
- ID information
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- DOI : 10.1248/yakushi.130.1421
- ISSN : 0031-6903
- Pubmed ID : 21048398
- Web of Science ID : WOS:000283522500005