論文

査読有り
2009年4月

A Pilot Study on the Role of Autoantibody Targeting the beta 1-Adrenergic Receptor in the Response to beta-blocker Therapy for Congestive Heart Failure

JOURNAL OF CARDIAC FAILURE
  • Yuji Nagatomo
  • ,
  • Tsutomu Yoshikawa
  • ,
  • Takashi Kohno
  • ,
  • Akihiro Yoshizawa
  • ,
  • Akiyasu Baba
  • ,
  • Toshihisa Anzai
  • ,
  • Tomomi Meguro
  • ,
  • Toru Satoh
  • ,
  • Satoshi Ogawa

15
3
開始ページ
224
終了ページ
232
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cardfail.2008.10.027
出版者・発行元
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS

Background: Autoantibodies directed against the beta 1-adrenergic receptor exert agonistlike actions by inducing receptor uncoupling and cause myocardial damage as well as fatal ventricular arrhythmias. Previous studies have shown that beta-blockers can modulate these actions of the autoantibodies. We investigated the influence of such autoantibodies in patients with congestive heart failure (CHF) receiving beta-blocker therapy.Methods and Results: Eighty-two CHF patients were randomly assigned to treatment with metoprolol or carvedilol for 16 weeks. Autoantibodies were detected in 20 patients (24%) by enzyme-linked immunosorbent assay. Left ventricular function in response to beta-blocker therapy did not differ significantly by the presence of the autoantibody in global analysis. However, changes of the left ventricular end-diastolic dimension (P = .04), end-systolic dimension (P < .01), and ejection fraction on radionuclide ventriculography (P = .02) were significantly larger in autoantibody-positive patients than antibody-negative patients. Changes in the plasma level of brain natriuretic peptide tended to be larger in autoantibody-positive patients (P = .09). The increase of heart rate normalized by the increase of plasma norepinephrine during exercise (an index of adrenergic responsiveness) showed a greater decrease in autoantibody-positive patients than autoantibody-negative patients (P = .035).Conclusion: Our data suggest that beta-blocker therapy might be more effective in CHF patients with autoantibodies targeting the (beta-adrenergic receptor. (J Cardiac Fail 2009:15:224-232)

リンク情報
DOI
https://doi.org/10.1016/j.cardfail.2008.10.027
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19327624
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265194300007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cardfail.2008.10.027
  • ISSN : 1071-9164
  • eISSN : 1532-8414
  • PubMed ID : 19327624
  • Web of Science ID : WOS:000265194300007

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