Shin-ichiro Kubo - My portal

Profile Information

Affiliation: Director (M.D., Ph.D.), Parkinson’s Disease Center, Eisei Hospital

J-GLOBAL ID: 201401084435289816
researchmap Member ID: B000242518

External link: http://kaken.nii.ac.jp/d/r/20327795.ja.html

Research Interests

Research Areas

Life sciences / Neurology /

Research History

2010

Juntendo University

Papers

Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.

Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-Ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita …

Proceedings of the National Academy of Sciences of the United States of America, 116(41) 20689-20699, Oct 8, 2019 Peer-reviewed
A Japanese multicenter survey characterizing pain in Parkinson's disease

Shin-ichiro Kubo, Shinsuke Hamada, Tetsuya Maeda, Tsuyoshi Uchiyama, Masaya Hashimoto, Nobuatsu Nomoto, Osamu Kano, Tatsuya Takahashi, Hiroo Terashi, Tetsuya Takahashi …

JOURNAL OF THE NEUROLOGICAL SCIENCES, 365 162-166, Jun, 2016 Peer-reviewed
Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics

Akio Mori, Taku Hatano, Yuzuru Imai, Yutaka Oji, Shin-ichiro Kubo, Kei Yamamoto, Makoto Murakami, Nobutaka Hattori

MOVEMENT DISORDERS, 31 S65-S65, Mar, 2016 Peer-reviewed
アルツハイマー病患者におけるガランタミンの効果と、有効症例の特徴の検討

須田晃充, 中山茶千子, 佐々木芙悠子, 森聡生, 中島明日香, 田中亮太, 久保紳一郎, 本井ゆみ子, 服部信孝

臨床神経学, 55(Suppl.) S368-S368, Dec, 2015
A Randomized Controlled Trial of Subcutaneous Apomorphine for Parkinson Disease: A Repeat Dose and Pharmacokinetic Study.

Nomoto M, Kubo S, Nagai M, Yamada T, Tamaoka A, Tsuboi Y, Hattori N, PD Study Group

Clinical neuropharmacology, 38(6) 241-247, Nov, 2015 Peer-reviewed
Lipid rafts involvement in the pathogenesis of Parkinson's disease.

Kubo S, Hatano T, Hattori N

Frontiers in bioscience, (Landmark edition), 20 263-279, 2015 Peer-reviewed
Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease

Taku Hatano, Manabu Funayama, Shin-ichiro Kubo, Ignacio F. Mata, Yutaka Oji, Akio Mori, Cyrus P. Zabetian, Sarah M. Waldherr, Hiroyo Yoshino, Genko Oyama …

NEUROBIOLOGY OF AGING, 35(11) 2656e17-23, Nov, 2014 Peer-reviewed
Effects of donepezil dose escalation in Parkinson's patients with dementia receiving long-term donepezil treatment: an exploratory study

Kei-Ichi Ishikawa, Yumiko Motoi, Yoshikuni Mizuno, Shin-Ichiro Kubo, Nobutaka Hattori

PSYCHOGERIATRICS, 14(2) 93-100, Jun, 2014 Peer-reviewed
Standard strategies for diagnosis and treatment of patients with newly diagnosed Parkinson disease: JAPAN.

Shin-Ichiro Kubo, Taku Hatano, Genko Oyama, Nobutaka Hattori

Neurology. Clinical practice, 3(6) 477-478, Dec, 2013 Peer-reviewed
Can parkin be a target for future treatment of Parkinson's disease?

Kubo Shin-ichiro, Hatano Taku, Takanashi Masashi, Hattori Nobutaka

EXPERT OPINION ON THERAPEUTIC TARGETS, 17(10) 1133-1144, Oct, 2013 Peer-reviewed
Bilateral Facial Nerve Palsy Due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody

Akio Mori, Taku Hatano, Shin-ichiro Kubo, Kana Ohno, Nobutaka Hattori, Hitoshi Suzuki, Isao Ohsawa, Ken-ichiro Hira, Yasuyuki Okuma, Kazuoki Hirano …

The American Journal of the Medical Sciences, 346(3) 240, Sep, 2013 Peer-reviewed
NEURODEGENERATIVE DISEASE Can synucleinopathy and tauopathy be identified during life?

Shin-ichiro Kubo, Nobutaka Hattori

NATURE REVIEWS NEUROLOGY, 9(8) 426-427, Aug, 2013 Peer-reviewed
Leukoencephalopathy associated with low-dose oral methotrexate

Sachiko Nakayama, Taku Hatano, Shin-ichiro Kubo, Akio Mori, Nobutaka Hattori, Yusuke Yamada, Michihiro Ogasawara, Naoto Tamura, Yoshinari Takasaki

Neurology and Clinical Neuroscience, 1(3) 128, May, 2013 Peer-reviewed
Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages

Taku Hatano, Shin-ichiro Kubo, Yuko Niijima-Ishii, Nobutaka Hattori, Yukihiro Sugita

PARKINSONISM & RELATED DISORDERS, 19(4) 477-479, Apr, 2013 Peer-reviewed
Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's disease.

Hiroya Utsumi, Yasuyuki Okuma, Osamu Kano, Yutaka Suzuki, Mutsumi Iijima, Hiroyuki Tomimitsu, Hideji Hashida, Shin-Ichiro Kubo, Masahiko Suzuki, Kazunori Nanri …

Internal medicine (Tokyo, Japan), 52(3) 325-32, 2013 Peer-reviewed
LRRK2 I2020T mutation is associated with tau pathology

Sachiko Ujiie, Taku Hatano, Shin-ichiro Kubo, Satoshi Imai, Shigeto Sato, Toshiki Uchihara, Saburo Yagishita, Kazuko Hasegawa, Hisayuki Kowa, Fumihiko Sakai …

PARKINSONISM & RELATED DISORDERS, 18(7) 819-823, Aug, 2012 Peer-reviewed
Atypical Miller Fisher syndrome associated with glutamate receptor antibodies.

Hatano T, Shimada Y, Kono A, Kubo S, Yokoyama K, Yoritaka A, Nakahara T, Takahashi Y, Hattori N, BMJ case …

2011, Sep, 2011 Peer-reviewed
DJ-1 associates with synaptic membranes

Yukiko Usami, Taku Hatano, Satoshi Imai, Shin-ichiro Kubo, Shigeto Sato, Shinji Saiki, Yoichiro Fujioka, Yusuke Ohba, Fumiaki Sato, Manabu Funayama …

NEUROBIOLOGY OF DISEASE, 43(3) 651-662, Sep, 2011 Peer-reviewed
Improvements in both psychosis and motor signs in Parkinson's disease, and changes in regional cerebral blood flow after electroconvulsive therapy

Chie Usui, Kotaro Hatta, Nagafumi Doi, Shinichiro Kubo, Rie Kamigaichi, Atsushi Nakanishi, Hiroyuki Nakamura, Nobutaka Hattori, Heii Arai

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 35(7) 1704-1708, Aug, 2011 Peer-reviewed
PARK2: Parkin Mutations Responsible for Familial Parkinson's Disease

Nobutaka Hattori, taku Hatano, Yutaka Machida, Shigeto Sato, Shin-Ichiro Kubo

MOVEMENT DISORDERS 4, 54, 2010 Peer-reviewed

Misc.

Identification of a Japanese family with Parkinson's disease due to the LRRK2 p.R1441G mutation

T. Hatano, M. Funayama, S. -I. Kubo, I. F. Mata, Y. Oji, A. Mori, C. P. Zabetian, S. Waldherr, H. Yoshino, G. Oyama …

MOVEMENT DISORDERS, 29 S52-S52, May, 2014
Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages

T. Hatano, S. I. Kubo, Y. Niijima-Ishii, H. Sugita, N. Hattori

MOVEMENT DISORDERS, 28 S276-S276, Jun, 2013
Parkin dysfunction results in detective depolarization-induced exocytosis of large dense core vesicles

H. Eguchi, M. Ohara-Imaizumi, Y. Chikaoka, S. Sato, T. Hatano, S. -I Kubo, Y. Mizuno, S. Nagamatsu, N. Hattori

MOVEMENT DISORDERS, 24 S30-S30, 2009
Effect of zonisamide on apoptosis in a SH-SY5Y cell line

S. Kawajiri, S. Saiki, Y. Machida, S. Sato, T. Hatano, S. -I Kubo, N. Hattori

MOVEMENT DISORDERS, 24 S362-S362, 2009
LRRK2 P755L variant in Parkinson's disease

H. Tomiyama, I. Mizuta, Y. Li, M. Funayama, H. Yoshino, L. Li, M. Murata, M. Yamamoto, S. -I. Kubo, Y. Mizuno …

MOVEMENT DISORDERS, 24 S155-S155, 2009
常染色体劣性パーキンソン病原因遺伝子産物parkinによるPINK1安定化機構の解析(平成19年度プロジェクト研究費研究成果報告書)

柴佳保里, 久保紳一郎

順天堂医学, 54(4) 559-559, Dec, 2008
Recurrent Guillain-Barre syndrome mith anti-GD1a/GD1b antibody in a 35 years old man

ISHIKAWA Keiichi, EDAHIRO Yoko, KUBO Shinichirou, YOKOYAMA Kazumasa, HATTORI Nobutaka

19(2) 339-341, Dec 1, 2008
CIDP associated with IgG-λ multiple myeloma in a 65 years old woman

EDAHIRO Yoko, ISHIKAWA Keiichi, KUBO Shinichirou, YOKOYAMA Kazumasa, HATTORI Nobutaka

19(2) 497-499, Dec 1, 2008
PINK1の局在の検討(平成19年度老人性疾患病態・治療研究センター研究発表会)

河尻澄宏, 波田野琢, 佐藤栄人, 久保紳一郎, 服部信孝

順天堂医学, 54(3) 413-414, Sep, 2008
ATP13A2の細胞内局在(平成19年度老人性疾患病態・治療研究センター研究発表会)

里史郎, 久保紳一郎, 水野美邦, 服部信孝

順天堂医学, 54(3) 407-408, Sep, 2008
LRRK2は脂質ラフトに局在する(平成19年度環境医学研究所プロジェクト研究成果報告書抄録)

久保紳一郎, 波田野琢, 今井哲史, 水野美邦, 服部信孝

順天堂医学, 54(3) 393-393, Sep, 2008
パーキンソン病(PD)の危険因子と報告されているGBA(Glueocerebrosidase)変異の常染色体劣性遺伝性PD(ARPD)における意義を検討する(平成19年度老人性疾患病態・治療研究センター研究発表会)

李林, 関根威, 富山弘幸, 李元哲, 舩山学, 今道洋子, 吉野浩代, 波田野琢, 久保紳一郎, 服部信孝

順天堂医学, 54(3) 419-419, Sep, 2008
PARK8(LRRK2)の機能,病態の検討 : LRRK2はmembrane traffickingに関与するか?(平成19年度老人性疾患病態・治療研究センター研究発表会)

江口博人, 波田野琢, 近岡洋子, 久保紳一郎, 服部信孝

順天堂医学, 54(3) 414-414, Sep, 2008
Parkin knockout mouse脳を用いた蛋白質プロファイリング解析(平成19年度老人性疾患病態・治療研究センター研究発表会)

今井哲司, 久保紳一郎, 波田野琢, 佐藤栄人, 里史明, 水野美邦, 服部信孝

順天堂医学, 54(3) 411-411, Sep, 2008
Parkin,PINK1のdigenic変異(平成19年度老人性疾患病態・治療研究センター研究発表会)

李元哲, 舩山学, 大井長和, 矢澤省吾, 宇山英一郎, 吉野浩代, 今道洋子, 高嶋博, 西岡健弥, 佐藤健一 …

順天堂医学, 54(3) 411-411, Sep, 2008
常染色体優性家族性パーキンソン病におけるGBA遺伝子L444P変異について(平成19年度老人性疾患病態・治療研究センター研究発表会)

関根威, 李林, 富山弘幸, 李元哲, 舩山学, 今道洋子, 吉野浩代, 波田野琢, 久保紳一郎, 服部信孝

順天堂医学, 54(3) 409-409, Sep, 2008
Update on PINK1-linked Parkinson's disease

225(5) 441-444, May 3, 2008
Possible localization of DJ-1 on the synaptic membrane in the mouse brain

Satoshi Imai, Yukiko Takata, Taku Hatano, Fumiaki Sato, Shigeto Sato, Shin-ichiro Kubo, Nobutaka Hattori

NEUROSCIENCE RESEARCH, 61 S203-S203, 2008
The roles of protein degradation systems in Parkinson disease

Nobutaka Hattori, Shigeto Sato, Satoshi Imai, Fumiaki Sato, Shin-ichiro Kubo

NEUROSCIENCE RESEARCH, 61 S22-S22, 2008
Proteomic analysis of parkin-deficient mice: The possible alteration in protein content in the midbrain

Taku Hatano, Satoshi Imai, Shin-Ichiro Kubo, Nobutaka Hattori

ANNALS OF NEUROLOGY, 64 S45-S45, 2008

Research Projects

Elucidation of a mechanism of Lewy body formation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

KUBO Shinichiro
Analyses of responsible protein for familial Parkinson's disease in lipid rafts.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

KUBO Shinichiro
To elucidate the pathogenesis of Parkinson' s disease and to develop a new therapy for the disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2008 - 2009

HATTORI Nobutaka, SATO Shigeto, SHIOMO Yashushi, HATANO Taku, FUNAYAMA Manabu
Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

HATTORI Nobutaka, KUBO Shinitiro, SATO Shigeto, TOMIYAMA Hiroyuki, IWAI Kazyhiro, SAKATA Shinithi
Functional analyses of the responsible proteins for familial Parkinson's disease in association with lipid rafts

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

KUBO Shin-ichiro, HATTORI Nobutaka
The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease gene

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

HATTORI Nobutaka, SATO Kenichi, KUBO Shin-ichiro, HIRASAWA Motoyuki