論文

査読有り
2017年12月

Interaction between calcitonin gene-related peptide-immunoreactive neurons and satellite cells via P2Y(12)R in the trigeminal ganglion is involved in neuropathic tongue pain in rats

EUROPEAN JOURNAL OF ORAL SCIENCES
  • Shiori Sugawara
  • Shinji Okada
  • Ayano Katagiri
  • Hiroto Saito
  • Tatsuro Suzuki
  • Hiroki Komiya
  • Kohei Kanno
  • Kinuyo Ohara
  • Toshimitsu Iinuma
  • Akira Toyofuku
  • Koichi Iwata
  • 全て表示

125
6
開始ページ
444
終了ページ
452
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/eos.12382
出版者・発行元
WILEY

The P2Y(12) receptor expressed in satellite cells of the trigeminal ganglion is thought to contribute to neuropathic pain. The functional interaction between neurons and satellite cells via P2Y(12) receptors and phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) underlying neuropathic pain in the tongue was evaluated in this study. Expression of P2Y(12) receptor was enhanced in pERK1/2-immunoreactive cells encircling trigeminal ganglion neurons after lingual nerve crush. The administration to lingual nerve crush rats of a selective P2Y(12) receptor antagonist, MRS2395, attenuated tongue hypersensitivity to mechanical and heat stimulation and suppressed the increase in the relative numbers of calcitonin gene-related peptide (CGRP)-immunoreactive neurons and neurons encircled by pERK1/2-immunoreactive cells. Administration of the P2Y(1,12,13) receptor agonist, 2-(methylthio)adenosine 5-diphosphate trisodium salt hydrate (2-MeSADP), to naive rats induced neuropathic pain in the tongue, as in lingual nerve crush rats. Co-administration of 2-MeSADP + MRS2395 to naive rats did not result in hypersensitivity of the tongue. The relative number of CGRP-immunoreactive neurons increased following this co-administration, but to a lesser degree than observed in 2-MeSADP-administrated naive rats, and the relative number of neurons encircled by pERK1/2-immunoreactive cells did not change. These results suggest that the interaction between activated satellite cells and CGRP-immunoreactive neurons via P2Y(12) receptors contributes to neuropathic pain in the tongue associated with lingual nerve injury.

リンク情報
DOI
https://doi.org/10.1111/eos.12382
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29023985
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000415054200005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/eos.12382
  • ISSN : 0909-8836
  • eISSN : 1600-0722
  • PubMed ID : 29023985
  • Web of Science ID : WOS:000415054200005

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