2018年6月1日
Antiproteinuric effects of renin–angiotensin inhibitors in lung cancer patients receiving bevacizumab
Cancer Chemotherapy and Pharmacology
- 巻
- 81
- 号
- 6
- 開始ページ
- 1051
- 終了ページ
- 1059
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00280-018-3580-1
- 出版者・発行元
- SPRINGER
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: The objective of this study was to investigate the effect of renin–angiotensin system inhibitors (RASIs) on bevacizumab (BV)-induced proteinuria in non-small cell lung cancer (NSCLC) patients. Materials and methods: We retrospectively reviewed the medical records of NSCLC patients receiving BV between 2008 and 2014 at 11 hospitals. The patients were categorized into three groups according to their antihypertensive drug use: RASI user, non-RASI user, and non-user groups. The primary outcome was a proteinuria event of any grade during the first 6 cycles of BV treatment. Results: A total of 211 patients were included, 89 of whom received antihypertensive drugs. Of these 89 patients, 49 were in the RASI user group, and 40 were in the non-RASI user group. The non-user group comprised 122 patients. The occurrence of proteinuria in the RASI user group was significantly lower than that in the non-RASI user group (P = 0.037) but was not significantly lower than that in the non-user group (P = 0.287). Patients using RASIs had a lower rate of proteinuria than those who did not use RASIs according to multivariate analysis (odds ratio 0.32; 95% confidence interval 0.12–0.86; P = 0.024). Conclusion: Our study suggests that RASI administration reduces the risk of proteinuria in patients receiving BV.
- リンク情報
-
- DOI
- https://doi.org/10.1007/s00280-018-3580-1
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29651572
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000433507600011&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045267951&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85045267951&origin=inward
- ID情報
-
- DOI : 10.1007/s00280-018-3580-1
- ISSN : 0344-5704
- eISSN : 1432-0843
- PubMed ID : 29651572
- SCOPUS ID : 85045267951
- Web of Science ID : WOS:000433507600011